Bcl‐2 family: Life‐or‐death switch

The Bcl‐2 family of proteins that consists of anti‐apoptotic and pro‐apoptotic members determines life‐or‐death of a cell by controlling the release of mitochondrial apoptogenic factors, cytochrome c and apoptosis‐inducing factor (AIF), that activate downstream executional phases, including the activation of death proteases called caspases. Cytochrome c release is, thus, central to apoptotic signal transduction in mammals, making study of the mechanism for cytochrome c release a major issue. Several models for cytochrome c release have been proposed, including rupture of mitochondrial outer membrane and involvement of a specific channel. Here, we provide an overview of recent findings on the role of Bcl‐2 family members in the life‐or‐death decision of a cell.

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