Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter

[1]  D. Hebenstreit,et al.  IL‐4 induces expression of TARC/CCL17 via two STAT6 binding sites , 2006, European journal of immunology.

[2]  R. Ransohoff,et al.  The many roles of chemokines and chemokine receptors in inflammation. , 2006, The New England journal of medicine.

[3]  S. Morris,et al.  Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta. , 2005, Gene.

[4]  Bing Ren,et al.  Direct isolation and identification of promoters in the human genome. , 2005, Genome research.

[5]  D. Hume,et al.  Transcription Factor Tfec Contributes to the IL-4-Inducible Expression of a Small Group of Genes in Mouse Macrophages Including the Granulocyte Colony-Stimulating Factor Receptor1 , 2005, The Journal of Immunology.

[6]  T. Bieber,et al.  Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus. , 2005, The Journal of investigative dermatology.

[7]  W. Owczarek,et al.  Serum thymus and activation‐regulated chemokine, macrophage‐derived chemokine and eotaxin as markers of severity of atopic dermatitis , 2005, Allergy.

[8]  Koichiro Nakamura,et al.  Differential production of Th1- and Th2-type chemokines by mouse Langerhans cells and splenic dendritic cells. , 2005, The Journal of investigative dermatology.

[9]  L. Hassman,et al.  Pulmonary Chemokine Expression Is Coordinately Regulated by STAT1, STAT6, and IFN-γ , 2004, The Journal of Immunology.

[10]  J. Kraus,et al.  STAT6 transcription factor binding sites with mismatches within the canonical 5′‐TTC…GAA‐3′ motif involved in regulation of δ‐ and µ‐opioid receptors , 2004, Journal of Neurochemistry.

[11]  N. Reich,et al.  Induction of genes involved in cell cycle progression by interleukin-4. , 2004, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[12]  M. Burdick,et al.  The Role of the Th2 CC Chemokine Ligand CCL17 in Pulmonary Fibrosis1 , 2004, The Journal of Immunology.

[13]  M. Miyazaki,et al.  CCL17 and IL-10 as Effectors That Enable Alternatively Activated Macrophages to Inhibit the Generation of Classically Activated Macrophages1 , 2004, The Journal of Immunology.

[14]  A. Frischauf,et al.  IL-4 and IL-13 Induce SOCS-1 Gene Expression in A549 Cells by Three Functional STAT6-Binding Motifs Located Upstream of the Transcription Initiation Site 1 , 2003, The Journal of Immunology.

[15]  P. Allavena,et al.  Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program 1 , 2003, The Journal of Immunology.

[16]  Loise M. Francisco,et al.  A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer. , 2003, Molecular immunology.

[17]  Koichiro Nakamura,et al.  Thymus and activation-regulated chemokine (TARC/CCL17) produced by mouse epidermal Langerhans cells is upregulated by TNF-alpha and IL-4 and downregulated by IFN-gamma. , 2003, Cytokine.

[18]  Q. Hamid,et al.  T helper type 2 cytokine receptors and associated transcription factors GATA-3, c-MAF, and signal transducer and activator of transcription factor-6 in induced sputum of atopic asthmatic patients. , 2003, Chest.

[19]  C. Lam,et al.  Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children , 2003, European Respiratory Journal.

[20]  J. Alferink,et al.  Compartmentalized Production of CCL17 In Vivo , 2003, The Journal of experimental medicine.

[21]  A. Stütz,et al.  The Th2 Cell Cytokines IL-4 and IL-13 Regulate Found in Inflammatory Zone 1/Resistin-Like Molecule α Gene Expression by a STAT6 and CCAAT/Enhancer-Binding Protein-Dependent Mechanism , 2003, The Journal of Immunology.

[22]  D. Mosser,et al.  The many faces of macrophage activation , 2003, Journal of leukocyte biology.

[23]  J. Kraus,et al.  Distinct palindromic extensions of the 5’‐TTC…GAA‐3’ motif allow STAT6 binding in vivo , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[24]  W. Sebald,et al.  Structure, binding, and antagonists in the IL-4/IL-13 receptor system. , 2002, Biochimica et biophysica acta.

[25]  John S. Welch,et al.  TH2 Cytokines and Allergic Challenge Induce Ym1 Expression in Macrophages by a STAT6-dependent Mechanism* , 2002, The Journal of Biological Chemistry.

[26]  S. Gordon,et al.  Inactivation of the F4/80 Glycoprotein in the Mouse Germ Line , 2002, Molecular and Cellular Biology.

[27]  M. Ericksen,et al.  Analysis of the Life Cycle of Stat6 , 2002, The Journal of Biological Chemistry.

[28]  J. Darnell,et al.  Signalling: STATs: transcriptional control and biological impact , 2002, Nature Reviews Molecular Cell Biology.

[29]  K. Matsushima,et al.  Increased levels of a TH2‐type CC chemokine thymus and activation‐regulated chemokine (TARC) in serum and induced sputum of asthmatics , 2002, Allergy.

[30]  K. Izuhara,et al.  PKCδ and ζ Mediate IL-4/IL-13-Induced Germline ϵ Transcription in Human B Cells: A Putative Regulation via PU.1 Phosphorylation , 2001 .

[31]  C. Glass,et al.  Regulation of Macrophage Gene Expression by the Peroxisome Proliferator-Activated Receptor-γ , 2001, Hormone Research in Paediatrics.

[32]  R. Homer,et al.  Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1 , 2001, The Journal of experimental medicine.

[33]  A. Iellem,et al.  Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells , 2001, The Journal of experimental medicine.

[34]  S. Gordon,et al.  Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic Lesions , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[35]  A. Tager,et al.  Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation , 2001, The Journal of experimental medicine.

[36]  S. Goerdt,et al.  Alternatively Activated Macrophages Differentially Express Fibronectin and Its Splice Variants and the Extracellular Matrix Protein βIG‐H3 , 2001, Scandinavian journal of immunology.

[37]  P. Bucher,et al.  DNA Binding Specificity of Different STAT Proteins , 2001, The Journal of Biological Chemistry.

[38]  I. Homma,et al.  Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice1 , 2001, The Journal of Immunology.

[39]  Y. Ohmori,et al.  Interleukin-4/STAT6 Represses STAT1 and NF-κB-dependent Transcription through Distinct Mechanisms* , 2000, The Journal of Biological Chemistry.

[40]  C. Horvath,et al.  STAT proteins and transcriptional responses to extracellular signals. , 2000, Trends in biochemical sciences.

[41]  V. Nguyen,et al.  Involvement of STAT-1 and Ets Family Members in Interferon-γ Induction of CD40 Transcription in Microglia/Macrophages* , 2000, The Journal of Biological Chemistry.

[42]  R. A. Hunt,et al.  Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3 : an autocrine loop for hypertrophy. , 2000, Hypertension.

[43]  P. Rothman,et al.  IL-4/IL-13 signaling beyond JAK/STAT. , 2000, The Journal of allergy and clinical immunology.

[44]  D. Conrad,et al.  Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription. , 2000, American journal of respiratory cell and molecular biology.

[45]  S. Gordon,et al.  The human eukaryotic initiation factor 4AI gene (EIF4A1) contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines. , 1999, Genomics.

[46]  V. Casolaro,et al.  Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial Cells , 1999, The Journal of Immunology.

[47]  U. Schindler,et al.  Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Paul J Hertzog,et al.  SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine , 1999, Cell.

[49]  F. Sallusto,et al.  Three chemokines with potential functions in T lymphocyte‐independent and ‐dependent B lymphocyte stimulation , 1999, European journal of immunology.

[50]  I. Lieberam,et al.  The murine β‐chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4+ T cells , 1999 .

[51]  James J. Campbell,et al.  The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells , 1999, Nature.

[52]  T. Willson,et al.  Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase , 1999, Nature.

[53]  S. Goerdt,et al.  Other functions, other genes: alternative activation of antigen-presenting cells. , 1999, Immunity.

[54]  K. Matsushima,et al.  Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. , 1998, The Journal of clinical investigation.

[55]  J. Ihle,et al.  Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6. , 1998, Blood.

[56]  R. Byrd,et al.  The Amino-terminal Domain of Human STAT4 , 1998, The Journal of Biological Chemistry.

[57]  M. Neurath,et al.  Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN-γ Promoter in Primary CD4+ T Lymphocytes , 1998, The Journal of Immunology.

[58]  R. Geha,et al.  CD40 ligation and IL‐4 use different mechanisms of transcriptional activation of the human lymphotoxin α promoter in B cells , 1998, European journal of immunology.

[59]  J. Darnell,et al.  Structure of the amino-terminal protein interaction domain of STAT-4. , 1998, Science.

[60]  P. Allavena,et al.  Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s , 1998, The Journal of experimental medicine.

[61]  Y. S. Choi,et al.  Identification and activation mechanism of the interleukin-4-induced nuclear factor binding to the CD23(b) promoter in human B lymphocytes. , 1997, Molecules and cells.

[62]  U. Schindler,et al.  Interaction of STAT5 Dimers on Two Low Affinity Binding Sites Mediates Interleukin 2 (IL-2) Stimulation of IL-2 Receptor α Gene Transcription* , 1997, The Journal of Biological Chemistry.

[63]  S. Goerdt,et al.  Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro , 1997, Immunology.

[64]  M. Lindsay,et al.  Superinduction of COX‐2 mRNA by cycloheximide and interleukin‐1β involves increased transcription and correlates with increased NF‐κB and JNK activation , 1997, FEBS letters.

[65]  Warren S. Alexander,et al.  A family of cytokine-inducible inhibitors of signalling , 1997, Nature.

[66]  O. Yoshie,et al.  The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4* , 1997, The Journal of Biological Chemistry.

[67]  N. Reich,et al.  Interleukin-4-induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene* , 1996, The Journal of Biological Chemistry.

[68]  U. Schindler,et al.  Requirements for interleukin-4-induced gene expression and functional characterization of Stat6 , 1996, Molecular and cellular biology.

[69]  B. Chait,et al.  DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites. , 1996, The EMBO journal.

[70]  T. Hoey,et al.  Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain , 1996, Science.

[71]  S. Akira,et al.  Essential role of Stat6 in IL-4 signalling , 1996, Nature.

[72]  M. Kaplan,et al.  Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.

[73]  R. Schreiber,et al.  Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. , 1995, Immunity.

[74]  S. McKnight,et al.  Components of a Stat recognition code: evidence for two layers of molecular selectivity. , 1995, Immunity.

[75]  N. Reich,et al.  Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. , 1993, Science.

[76]  J. Ravetch,et al.  Biochemical characterization of a gamma interferon-inducible cytokine (IP-10) , 1987, The Journal of experimental medicine.

[77]  F. Denizot,et al.  Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. , 1986, Journal of immunological methods.

[78]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[79]  J. Cyster,et al.  Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. , 2005, Annual review of immunology.

[80]  G. Randolph,et al.  Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances , 2004, Springer Seminars in Immunopathology.

[81]  H. Hirata,et al.  Production of TARC and MDC by Naive T Cells in Asthmatic Patients , 2004, Journal of Clinical Immunology.

[82]  S. Gordon.  Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[83]  M. C. Berin,et al.  The Role of TARC in the Pathogenesis of Allergic Asthma. , 2002, Drug news & perspectives.

[84]  Berin Mc.  The Role of TARC in the Pathogenesis of Allergic Asthma. , 2002 .

[85]  K. Izuhara,et al.  PKCdelta and zeta mediate IL-4/IL-13-induced germline epsilon transcription in human B cells: a putative regulation via PU.1 phosphorylation. , 2001, Biochemical and biophysical research communications.

[86]  K. Matsushima,et al.  Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. , 1999, International immunology.

[87]  T. Willson,et al.  Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. , 1999, Nature.

[88]  W. Paul,et al.  The IL-4 receptor: signaling mechanisms and biologic functions. , 1999, Annual review of immunology.

[89]  I. Lieberam,et al.  The murine beta-chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4+ T cells. , 1999, European journal of immunology.

[90]  V. Casolaro,et al.  Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells. , 1999, Journal of immunology.

[91]  E. Schmitt,et al.  IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes. , 1998, Journal of immunology.