The battle against immunopathology: infectious tolerance mediated by regulatory T cells

[1]  M. Yazdanbakhsh,et al.  Regulatory B-cell induction by helminths: implications for allergic disease. , 2011, The Journal of allergy and clinical immunology.

[2]  F. Regateiro,et al.  TGF-β in transplantation tolerance. , 2011, Current opinion in immunology.

[3]  F. Regateiro,et al.  Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance , 2011, The Journal of experimental medicine.

[4]  Loise M. Francisco,et al.  Physiologic Control of IDO Competence in Splenic Dendritic Cells , 2011, The Journal of Immunology.

[5]  S. Bicciato,et al.  Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells , 2011, Nature Immunology.

[6]  J. Bluestone,et al.  Control of TH17 cells occurs in the Small Intestine , 2011, Nature.

[7]  Fiona Powrie,et al.  Intestinal homeostasis and its breakdown in inflammatory bowel disease , 2011, Nature.

[8]  D. Vignali,et al.  Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance , 2011, The Journal of Immunology.

[9]  R. Maizels,et al.  Chronic Helminth Infection Promotes Immune Regulation In Vivo through Dominance of CD11cloCD103− Dendritic Cells , 2011, The Journal of Immunology.

[10]  S. Hapfelmeier,et al.  Intestinal bacterial colonization induces mutualistic regulatory T cell responses. , 2011, Immunity.

[11]  H. Weiner,et al.  Oral tolerance , 2011, Immunological reviews.

[12]  G. Anderson,et al.  Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4 , 2011, Science.

[13]  A. Rudensky,et al.  Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. , 2011, Immunity.

[14]  Francis J. Huber,et al.  Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. , 2011, Immunity.

[15]  K. Honda,et al.  Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species , 2011, Science.

[16]  S. Mazmanian,et al.  Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? , 2010, Science.

[17]  Scott A. Brown,et al.  IL-35-mediated induction of a potent regulatory T cell population , 2010, Nature Immunology.

[18]  Laurence A. Turka,et al.  The Immune Tolerance Network at 10 years: tolerance research at the bedside , 2010, Nature Reviews Immunology.

[19]  A. Rudensky,et al.  Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway , 2010, The Journal of experimental medicine.

[20]  S. Dasgupta,et al.  Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression , 2010, The Journal of Immunology.

[21]  R. Schwartz,et al.  Induction of T cell anergy: integration of environmental cues and infectious tolerance. , 2010, Current opinion in immunology.

[22]  E. Hauben,et al.  Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. , 2010, Blood.

[23]  S. Gibbs,et al.  Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens , 2010, European journal of immunology.

[24]  S. Mazmanian,et al.  Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota , 2010, Proceedings of the National Academy of Sciences.

[25]  F. Regateiro,et al.  Connecting the mechanisms of T‐cell regulation: dendritic cells as the missing link , 2010, Immunological reviews.

[26]  H. Waldmann,et al.  Tolerogenicity is not an absolute property of a dendritic cell , 2010, European journal of immunology.

[27]  J. Bach,et al.  The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update , 2010, Clinical and experimental immunology.

[28]  J. Isaacs,et al.  Development of Dendritic Cell-Based Immunotherapy for Autoimmunity , 2010, International reviews of immunology.

[29]  Y. Belkaid,et al.  Microbe–dendritic cell dialog controls regulatory T‐cell fate , 2010, Immunological reviews.

[30]  O. Majdic,et al.  Human rhinoviruses induce IL‐35‐producing Treg via induction of B7‐H1 (CD274) and sialoadhesin (CD169) on DC , 2010, European journal of immunology.

[31]  C. Loddenkemper,et al.  Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells , 2009, European journal of immunology.

[32]  Toshiharu Onodera,et al.  Constitutive Expression of IDO by Dendritic Cells of Mesenteric Lymph Nodes: Functional Involvement of the CTLA-4/B7 and CCL22/CCR4 Interactions1 , 2009, The Journal of Immunology.

[33]  R. Maizels,et al.  Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity , 2009, Molecular and biochemical parasitology.

[34]  Kathy O. Lui,et al.  Infectious tolerance via the consumption of essential amino acids and mTOR signaling , 2009, Proceedings of the National Academy of Sciences.

[35]  P. Worley,et al.  The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. , 2009, Immunity.

[36]  A. Wells.  New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting , 2009, The Journal of Immunology.

[37]  E. Shevach.  Mechanisms of foxp3+ T regulatory cell-mediated suppression. , 2009, Immunity.

[38]  G. Illei,et al.  Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures. , 2009, Blood.

[39]  A. Thomson,et al.  Immunoregulatory functions of mTOR inhibition , 2009, Nature Reviews Immunology.

[40]  Gisen Kim,et al.  Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells. , 2009, Immunity.

[41]  A. Cooke,et al.  Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice , 2009, European journal of immunology.

[42]  F. Powrie,et al.  Regulatory lymphocytes and intestinal inflammation. , 2009, Annual review of immunology.

[43]  R. Maizels,et al.  Early recruitment of natural CD4+Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection , 2009, European journal of immunology.

[44]  P. Chambon,et al.  Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. , 2008, Immunity.

[45]  R. Maizels,et al.  Expansion of Foxp3+ Regulatory T Cells in Mice Infected with the Filarial Parasite Brugia malayi1 , 2008, The Journal of Immunology.

[46]  T. Nomura,et al.  CTLA-4 Control over Foxp3+ Regulatory T Cell Function , 2008, Science.

[47]  E. Butcher,et al.  CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease , 2008, Nature Immunology.

[48]  Shimon Sakaguchi,et al.  Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation , 2008, Proceedings of the National Academy of Sciences.

[49]  M. Sayegh,et al.  Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells , 2008, Proceedings of the National Academy of Sciences.

[50]  A. Kulkarni,et al.  A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells , 2008, Nature Immunology.

[51]  B. Dale,et al.  Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II1 , 2008, The Journal of Immunology.

[52]  E. Chi,et al.  Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. , 2008, Immunity.

[53]  G. Freeman,et al.  PD-1 and its ligands in tolerance and immunity. , 2008, Annual review of immunology.

[54]  C. Loddenkemper,et al.  Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection , 2008, Infection and Immunity.

[55]  E. Shevach,et al.  CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β–dependent manner , 2008, The Journal of experimental medicine.

[56]  R. Selvaraj,et al.  Mitigation of Experimental Allergic Encephalomyelitis by TGF-β Induced Foxp3+ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance1 , 2008, The Journal of Immunology.

[57]  A. Hoerauf,et al.  Helminth Infection with Litomosoides sigmodontis Induces Regulatory T Cells and Inhibits Allergic Sensitization, Airway Inflammation, and Hyperreactivity in a Murine Asthma Model1 , 2008, The Journal of Immunology.

[58]  R. Steinman,et al.  Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. , 2007, Blood.

[59]  K. Boyd,et al.  The inhibitory cytokine IL-35 contributes to regulatory T-cell function , 2007, Nature.

[60]  E. Boye,et al.  The Gcn2 Kinase as a Cell Cycle Regulator , 2007, Cell cycle.

[61]  D. Hardie,et al.  AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy , 2007, Nature Reviews Molecular Cell Biology.

[62]  J. Bluestone,et al.  Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice , 2007 .

[63]  A. Rudensky,et al.  Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10 , 2007, Nature Immunology.

[64]  Y. Belkaid,et al.  A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism , 2007, The Journal of experimental medicine.

[65]  Y. Belkaid,et al.  Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid , 2007, The Journal of experimental medicine.

[66]  R. Noelle,et al.  All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation , 2007, The Journal of experimental medicine.

[67]  A. Thomson,et al.  Tolerogenic dendritic cells and the quest for transplant tolerance , 2007, Nature Reviews Immunology.

[68]  H. Waldmann,et al.  Induction of Regulatory T Cells and Dominant Tolerance by Dendritic Cells Incapable of Full Activation1 , 2007, The Journal of Immunology.

[69]  Hilde Cheroutre,et al.  Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid , 2007, Science.

[70]  R. Maizels,et al.  Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection , 2007, European journal of immunology.

[71]  C. Piccirillo,et al.  Impairment of dendritic cell function by excretory‐secretory products: A potential mechanism for nematode‐induced immunosuppression , 2007, European journal of immunology.

[72]  J. Powell,et al.  A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy1 , 2007, The Journal of Immunology.

[73]  J. Powell,et al.  Adenosine and anergy , 2007, Autoimmunity.

[74]  A. Cooke,et al.  Inhibition of Autoimmune Type 1 Diabetes by Gastrointestinal Helminth Infection , 2006, Infection and Immunity.

[75]  H. Waldmann,et al.  Immune privilege induced by regulatory T cells in transplantation tolerance , 2006, Immunological reviews.

[76]  D. Elliott,et al.  Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[77]  Katharina Fleischhauer,et al.  Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans , 2006, Immunological reviews.

[78]  H. Waldmann,et al.  Infectious tolerance and the long‐term acceptance of transplanted tissue , 2006, Immunological reviews.

[79]  Michael Loran Dustin,et al.  Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo , 2006, The Journal of experimental medicine.

[80]  T. Geiger,et al.  IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[81]  S. Blüml,et al.  Human Rhinoviruses Inhibit the Accessory Function of Dendritic Cells by Inducing Sialoadhesin and B7-H1 Expression1 , 2005, The Journal of Immunology.

[82]  F. Chirdo,et al.  Immunomodulatory dendritic cells in intestinal lamina propria , 2005, European journal of immunology.

[83]  B. Baban,et al.  GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. , 2005, Immunity.

[84]  M. Roncarolo,et al.  Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. , 2005, Blood.

[85]  D. Vignali,et al.  Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)1 , 2005, The Journal of Immunology.

[86]  B. Baban,et al.  Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. , 2004, International immunology.

[87]  C. Drake,et al.  Role of LAG-3 in regulatory T cells. , 2004, Immunity.

[88]  A. Macpherson,et al.  Interactions between commensal intestinal bacteria and the immune system , 2004, Nature Reviews Immunology.

[89]  D. Zélénika,et al.  Induction of foxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants1 , 2004, The Journal of Immunology.

[90]  In-Jeong Kim,et al.  Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo1 , 2004, The Journal of Immunology.

[91]  S. Zheng,et al.  Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-101 , 2004, The Journal of Immunology.

[92]  A. Enk,et al.  Human CD25+ regulatory T cells: two subsets defined by the integrins α4β7 or α4β1 confer distinct suppressive properties upon CD4+ T helper cells , 2004 .

[93]  S. Kaveri,et al.  Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells1 , 2004, The Journal of Immunology.

[94]  Li Li,et al.  Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.

[95]  T. Utsugi,et al.  CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. , 2003, Immunity.

[96]  R. Schwartz.  T cell anergy. , 2003, Annual review of immunology.

[97]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[98]  T. Nomura,et al.  Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .

[99]  G. Schuler,et al.  Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells , 2002, The Journal of experimental medicine.

[100]  C. Arias,et al.  Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. , 2002, Blood.

[101]  A. Enk,et al.  Infectious Tolerance , 2002, The Journal of experimental medicine.

[102]  Sayuri Yamazaki,et al.  Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance , 2001, Immunological reviews.

[103]  A. Bowcock,et al.  JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. , 2000, The Journal of clinical investigation.

[104]  H. Waldmann,et al.  Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance1 , 2000, The Journal of Immunology.

[105]  H. Waldmann,et al.  CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression. , 1999, Journal of immunology.

[106]  A. Iwasaki,et al.  Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells , 1999, The Journal of experimental medicine.

[107]  R. Schwartz,et al.  Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. , 1999, Journal of immunology.

[108]  Hervé Groux,et al.  A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.

[109]  H. Waldmann,et al.  T cell suppression in transplantation tolerance through linked recognition. , 1996, Journal of immunology.

[110]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[111]  S. Cobbold,et al.  Mechanisms in CD4 antibody‐mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells , 1994, European journal of immunology.

[112]  D. Kioussis,et al.  "Infectious" transplantation tolerance , 1993, Science.

[113]  G. Proetzel,et al.  Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.

[114]  H. Waldmann,et al.  Induction of tolerance by monoclonal antibody therapy , 1986, Nature.

[115]  I. Bursuker,et al.  Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity , 1984, The Journal of experimental medicine.

[116]  I. Bursuker,et al.  T cell-mediated suppression of the concomitant antitumor immune response as an example of transplantation tolerance. , 1984, Transplantation proceedings.

[117]  D. Green,et al.  Functional deletion of different Ly-1 T-cell-inducer subset activities by Ly-2 suppressor T lymphocytes. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[118]  R. Gershon,et al.  Infectious immunological tolerance. , 1971, Immunology.

[119]  P. Medawar,et al.  ‘Actively Acquired Tolerance’ of Foreign Cells , 1953, Nature.

[120]  박주홍,et al.  The Toll-Like Receptor 2 pathway Establishes Colonization by a Commensal of the Human Microbiota , 2011 .

[121]  M. Horton,et al.  A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. , 2008, Blood.

[122]  J. Bluestone,et al.  Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. , 2007, Nature.

[123]  Pau Serra,et al.  Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice , 2006, Nature Immunology.

[124]  A. Enk,et al.  Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells. , 2004, European journal of immunology.

[125]  J. Casanova,et al.  X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy , 2001, Nature Genetics.

[126]  D. Galas,et al.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse , 2001, Nature Genetics.

[127]  H. Ochs,et al.  The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 , 2001, Nature Genetics.

[128]  D. Green,et al.  Immunoregulatory T-cell pathways. , 1983, Annual review of immunology.