Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion

[1]  Zhijun Zhang,et al.  Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion , 2014, Journal of Neuroinflammation.

[2]  A. Ergul,et al.  Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats , 2013, Brain Research.

[3]  Guo-Yuan Yang,et al.  Netrin-1 Overexpression Promotes White Matter Repairing and Remodeling after Focal Cerebral Ischemia in Mice , 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[4]  E. Mercken,et al.  Metformin improves healthspan and lifespan in mice , 2013, Nature Communications.

[5]  Jian rong Liu,et al.  The protective role of Tongxinluo on blood-brain barrier after ischemia-reperfusion brain injury. , 2013, Journal of ethnopharmacology.

[6]  S. Dohgu,et al.  Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells. , 2013, Biochemical and biophysical research communications.

[7]  D. Hardie,et al.  Metabolism of inflammation limited by AMPK and pseudo-starvation , 2013, Nature.

[8]  Guo-Yuan Yang,et al.  CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice , 2013, Stroke.

[9]  Jing Wang,et al.  Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. , 2012, Cell stem cell.

[10]  D. Lim,et al.  An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation. , 2012, Cell stem cell.

[11]  A. Salminen,et al.  AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network , 2012, Ageing Research Reviews.

[12]  Hyung Soo Han,et al.  Neuroprotective mechanisms of hypothermia in brain ischaemia , 2012, Nature Reviews Neuroscience.

[13]  R. Shaw,et al.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.

[14]  K. Suk,et al.  Mild Hypothermia Attenuates Intercellular Adhesion Molecule-1 Induction via Activation of Extracellular Signal-Regulated Kinase-1/2 in a Focal Cerebral Ischemia Model , 2011, Stroke research and treatment.

[15]  L. McCullough,et al.  Effects of Metformin in Experimental Stroke , 2010, Stroke.

[16]  Wakako Fujita-Hamabe,et al.  RETRACTED: The importance of regulation of blood glucose levels through activation of peripheral 5′-AMP-activated protein kinase on ischemic neuronal damage , 2010, Brain Research.

[17]  W. Schäbitz,et al.  Effects of G-CSF treatment on neutrophil mobilization and neurological outcome after transient focal ischemia , 2010, Experimental Neurology.

[18]  Ties Boerma,et al.  Global and regional causes of death. , 2009, British medical bulletin.

[19]  M. Sugimachi,et al.  Metformin Prevents Progression of Heart Failure in Dogs: Role of AMP-Activated Protein Kinase , 2009, Circulation.

[20]  K. Norga,et al.  AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons , 2009, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[21]  S. Jha,et al.  Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling , 2008, Diabetes.

[22]  Joseph P Broderick,et al.  National US Estimates of Recombinant Tissue Plasminogen Activator Use: ICD-9 Codes Substantially Underestimate , 2008, Stroke.

[23]  M. Moskowitz,et al.  Adiponectin Prevents Cerebral Ischemic Injury Through Endothelial Nitric Oxide Synthase–Dependent Mechanisms , 2008, Circulation.

[24]  L. Schlichter,et al.  Minocycline protects the blood–brain barrier and reduces edema following intracerebral hemorrhage in the rat , 2007, Experimental Neurology.

[25]  J. Milbrandt,et al.  Resveratrol stimulates AMP kinase activity in neurons , 2007, Proceedings of the National Academy of Sciences.

[26]  J. Greenwood,et al.  Statins and the vascular endothelial inflammatory response. , 2007, Trends in immunology.

[27]  M. Chopp,et al.  Neurogenesis, Angiogenesis, and MRI Indices of Functional Recovery From Stroke , 2007, Stroke.

[28]  Kunihiro Suzuki,et al.  Metformin Inhibits Cytokine-Induced Nuclear Factor &kgr;B Activation Via AMP-Activated Protein Kinase Activation in Vascular Endothelial Cells , 2006, Hypertension.

[29]  E. Diamanti-Kandarakis,et al.  Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin. , 2006, Human reproduction.

[30]  J. Gidday Cerebral preconditioning and ischaemic tolerance , 2006, Nature Reviews Neuroscience.

[31]  Idf Clinical Guidelines Task Force Global Guideline for Type 2 Diabetes: recommendations for standard, comprehensive, and minimal care , 2006, Diabetic medicine : a journal of the British Diabetic Association.

[32]  B. Viollet,et al.  Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. , 2006, Diabetes.

[33]  James L. Young,et al.  Metformin Inhibits Proinflammatory Responses and Nuclear Factor-&kgr;B in Human Vascular Wall Cells , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[34]  S. Kihara,et al.  Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms , 2005, Nature Medicine.

[35]  R. Holman,et al.  Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) , 1998, The Lancet.

[36]  M Chopp,et al.  Antibodies against Adhesion Molecules Reduce Apoptosis after Transient Middle Cerebral Artery Occlusion in Rat Brain , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[37]  P. Tak,et al.  NF-kappaB: a key role in inflammatory diseases. , 2001, The Journal of clinical investigation.

[38]  P. Tak,et al.  NF-κB: a key role in inflammatory diseases , 2001 .