The inhibitor of differentiation isoform Id1b, generated by alternative splicing, maintains cell quiescence and confers self-renewal and cancer stem cell-like properties.

[1]  M. Ponz-Sarvisé,et al.  Differential tumor expression of inhibitor of differentiation-1 in prostate cancer patients with extreme clinical phenotypes and prognostic implications. , 2014, Clinical genitourinary cancer.

[2]  A. Iavarone,et al.  The ID proteins: master regulators of cancer stem cells and tumour aggressiveness , 2014, Nature Reviews Cancer.

[3]  E. Gangoso,et al.  A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype , 2014, Cell Death and Disease.

[4]  Wenjing Zhang,et al.  Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. , 2013, Oncology reports.

[5]  C. Richichi,et al.  Marker-independent method for isolating slow-dividing cancer stem cells in human glioblastoma. , 2013, Neoplasia.

[6]  W. Jiang,et al.  The mRNA expression of inhibitors of DNA binding-1 and -2 is associated with advanced tumour stage and adverse clinical outcome in human breast cancer. , 2013, Anticancer research.

[7]  Yingying Lin,et al.  ID1 affects the efficacy of radiotherapy in glioblastoma through inhibition of DNA repair pathways , 2013, Medical Oncology.

[8]  J. Bosch-Barrera,et al.  Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy , 2013, Journal of Translational Medicine.

[9]  Lindy E. Barrett,et al.  Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. , 2013, The Journal of clinical investigation.

[10]  F. Papaccio,et al.  Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  A. Krešo,et al.  ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. , 2012, Cancer cell.

[12]  Lindy E. Barrett,et al.  Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma. , 2012, Cancer cell.

[13]  Peter Dirks,et al.  Cancer stem cells: an evolving concept , 2012, Nature Reviews Cancer.

[14]  A. Tanimoto,et al.  Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple‐negative breast cancer , 2011, Histopathology.

[15]  A. Allan,et al.  The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells , 2011, Stem Cell Reviews and Reports.

[16]  B. Vojtesek,et al.  The role of P63 in cancer, stem cells and cancer stem cells , 2011, Cellular & Molecular Biology Letters.

[17]  J. Baselga,et al.  TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma. , 2010, Cancer cell.

[18]  M. Berger,et al.  Non-stem cell origin for oligodendroglioma. , 2010, Cancer cell.

[19]  C. Zahnow,et al.  CCAAT/enhancer-binding protein β: its role in breast cancer and associations with receptor tyrosine kinases , 2009, Expert Reviews in Molecular Medicine.

[20]  J. Moreb.  Aldehyde dehydrogenase as a marker for stem cells. , 2008, Current stem cell research & therapy.

[21]  N. Meydan,et al.  Id-1: Regulator of EGFR and VEGF and potential target for colorectal cancer therapy , 2008, Journal of experimental & clinical cancer research : CR.

[22]  Robert Machold,et al.  Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. , 2008, Cancer cell.

[23]  Hong Zhang,et al.  Overexpression of Id-1 protein is a marker in colorectal cancer progression. , 2008, Oncology reports.

[24]  J. Dick,et al.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice , 2007, Nature.

[25]  Xiaomeng Zhang,et al.  The multiple roles of Id-1 in cancer progression. , 2006, Differentiation; research in biological diversity.

[26]  A. Iavarone,et al.  Id family of helix-loop-helix proteins in cancer , 2005, Nature Reviews Cancer.

[27]  Andy J. Minn,et al.  Genes that mediate breast cancer metastasis to lung , 2005, Nature.

[28]  W. Gerald,et al.  Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. , 2005, The Journal of clinical investigation.

[29]  R. Debs,et al.  Id genes and proteins as promising targets in cancer therapy. , 2004, Trends in molecular medicine.

[30]  J. Nichols,et al.  BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3 , 2003, Cell.

[31]  Y. Itahana,et al.  Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[32]  P. Fishman,et al.  Inhibition of primary colon carcinoma growth and liver metastasis by the A3 adenosine receptor agonist CF101 , 2003, British Journal of Cancer.

[33]  A. Olshen,et al.  Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[34]  M. Schindl,et al.  Overexpression of Id‐1 is associated with poor clinical outcome in node negative breast cancer , 2003, International journal of cancer.

[35]  K. Becker,et al.  Analysis of microarray data using Z score transformation. , 2003, The Journal of molecular diagnostics : JMD.

[36]  T. Speed,et al.  Summaries of Affymetrix GeneChip probe level data. , 2003, Nucleic acids research.

[37]  Y. Yokota.  Id and development , 2001, Oncogene.

[38]  C. Potten,et al.  Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. , 2001, Cancer research.

[39]  M. Schindl,et al.  Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer. , 2001, Cancer research.

[40]  C. Bortner,et al.  Modification of Alternative Splicing of Bcl-x Pre-mRNA in Prostate and Breast Cancer Cells , 2001, The Journal of Biological Chemistry.

[41]  A. Nordheim,et al.  Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells* , 1999, The Journal of Biological Chemistry.

[42]  M. Collector,et al.  Hematopoietic stem cell tracking in vivo: a comparison of short-term and long-term repopulating cells. , 1999, Blood.

[43]  T. Sakai,et al.  Differential activity of a variant form of the human Id‐1 protein generated by alternative splicing , 1998, FEBS letters.

[44]  W. Kuo,et al.  Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. , 1997, Biochemical and biophysical research communications.

[45]  M. Israel,et al.  Molecular cloning of the cDNA encoding a helix-loop-helix protein, mouse ID1B: tissue-specific expression of ID1A and ID1B genes. , 1996, Biochimica et biophysica acta.

[46]  R. Kelly,et al.  Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization. , 1994, The Journal of biological chemistry.

[47]  J. Campisi,et al.  Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. , 1994, The Journal of biological chemistry.

[48]  C. Perez-stable,et al.  Id-1B, an alternatively spliced isoform of the inhibitor of differentiation-1, impairs cancer cell malignancy through inhibition of proliferation and angiogenesis. , 2014, Current molecular medicine.

[49]  P. P. Di Fiore,et al.  Functional purification of human and mouse mammary stem cells. , 2012, Methods in molecular biology.

[50]  C. Behrens,et al.  TITLE PAGE Title: Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance , 2011 .