Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery

[1]  T. Moos,et al.  Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload , 2020, Glia.

[2]  A. Molofsky,et al.  Astrocytes and Microglia: In Sickness and in Health , 2020, Trends in Neurosciences.

[3]  D. Gelain,et al.  Short and long TNF‐alpha exposure recapitulates canonical astrogliosis events in human‐induced pluripotent stem cells‐derived astrocytes , 2020, Glia.

[4]  J. Kreutzer,et al.  Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system , 2019, Scientific Reports.

[5]  S. Cuzzocrea,et al.  Astrocytes: Role and Functions in Brain Pathologies , 2019, Front. Pharmacol..

[6]  W. Baumgärtner,et al.  Neurotoxic potential of reactive astrocytes in canine distemper demyelinating leukoencephalitis , 2019, Scientific Reports.

[7]  Jialin C. Zheng,et al.  Reactive Astrocytes in Neurodegenerative Diseases , 2019, Aging and disease.

[8]  Ruotian Jiang,et al.  Astrocyte morphology: Diversity, plasticity, and role in neurological diseases , 2019, CNS neuroscience & therapeutics.

[9]  L. Ferraiuolo,et al.  Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS , 2019, EBioMedicine.

[10]  Jean-Charles Sanchez,et al.  Profiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry , 2018, Journal of Neuroinflammation.

[11]  Marcus Groettrup,et al.  Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress , 2018, Cell Death & Differentiation.

[12]  S. Stifani,et al.  Nuclear factor‐kappaB regulates multiple steps of gliogenesis in the developing murine cerebral cortex , 2018, Glia.

[13]  T. Boeckers,et al.  NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS , 2018, The EMBO journal.

[14]  Ben A. Barres,et al.  Normal aging induces A1-like astrocyte reactivity , 2018, Proceedings of the National Academy of Sciences.

[15]  K. Eggan,et al.  Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1 , 2017, Stem cell reports.

[16]  B. Barres,et al.  Reactive Astrocytes: Production, Function, and Therapeutic Potential. , 2017, Immunity.

[17]  K. Brennand,et al.  An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells , 2017, bioRxiv.

[18]  D. Souza,et al.  Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain , 2016, Molecular Neurobiology.

[19]  Manoj Kumar,et al.  INGE GRUNDKE-IQBAL AWARD FOR ALZHEIMER’S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA , 2019, Alzheimer's & Dementia.

[20]  M. Wajner,et al.  Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release , 2016, Molecular Neurobiology.

[21]  J. Xu,et al.  Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors , 2016, Stem cell reports.

[22]  E. Shigetomi,et al.  Probing the Complexities of Astrocyte Calcium Signaling. , 2016, Trends in cell biology.

[23]  J. Godbout,et al.  Sequential activation of microglia and astrocyte cytokine expression precedes increased iba‐1 or GFAP immunoreactivity following systemic immune challenge , 2016, Glia.

[24]  E. Chang,et al.  Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse , 2016, Neuron.

[25]  J. Zuchero,et al.  Glia in mammalian development and disease , 2015, Development.

[26]  R. Chung,et al.  The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia , 2015, Front. Cell. Neurosci..

[27]  F. Court,et al.  Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling , 2015, Front. Cell. Neurosci..

[28]  L. Ferraiuolo.  The non-cell-autonomous component of ALS: new in vitro models and future challenges. , 2014, Biochemical Society transactions.

[29]  M. Turner,et al.  CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis , 2014, Acta neuropathologica communications.

[30]  Sunhee C. Lee,et al.  LPS and IL‐1 differentially activate mouse and human astrocytes: Role of CD14 , 2014, Glia.

[31]  Robert H. Brown,et al.  Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability. , 2013, Journal of neurophysiology.

[32]  M. Rao,et al.  Efficient Generation of Astrocytes from Human Pluripotent Stem Cells in Defined Conditions , 2013, Stem cells.

[33]  S. Finkbeiner,et al.  Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy , 2013, Proceedings of the National Academy of Sciences.

[34]  B. Barres,et al.  Genomic Analysis of Reactive Astrogliosis , 2012, The Journal of Neuroscience.

[35]  R. Pedersen,et al.  Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms , 2011, Cell Death and Differentiation.

[36]  L. Barbeito,et al.  Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis , 2011, Proceedings of the National Academy of Sciences.

[37]  J. Mendell,et al.  Astrocytes from Familial and Sporadic ALS Patients are Toxic to Motor Neurons , 2011, Nature Biotechnology.

[38]  R. Dringen,et al.  Copper-treatment increases the cellular GSH content and accelerates GSH export from cultured rat astrocytes , 2011, Neuroscience Letters.

[39]  J. Ojemann,et al.  Uniquely Hominid Features of Adult Human Astrocytes , 2009, The Journal of Neuroscience.

[40]  F. Gage,et al.  Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. , 2008, Cell stem cell.

[41]  K. Eggan,et al.  Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. , 2008, Cell stem cell.

[42]  Thomas D. Schmittgen,et al.  Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.

[43]  L. Ferraiuolo,et al.  Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALS , 2007, The Journal of Neuroscience.

[44]  K. Dietz,et al.  Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia , 2007, Histopathology.

[45]  Hynek Wichterle,et al.  Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons , 2007, Nature Neuroscience.

[46]  N. Bresolin,et al.  Production of monocyte chemoattractant protein‐1 in amyotrophic lateral sclerosis , 2005, Muscle & nerve.

[47]  G. Borasio,et al.  Glial Proliferation and Metabotropic Glutamate Receptor Expression in Amyotrophic Lateral Sclerosis , 2004, Journal of neuropathology and experimental neurology.

[48]  G. Mora,et al.  Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis , 2000, Neuroscience Letters.

[49]  R. Veerhuis,et al.  Complement C1-inhibitor expression in Alzheimer’s disease , 1998, Acta Neuropathologica.

[50]  D. Schiffer,et al.  Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis , 1996, Journal of the Neurological Sciences.

[51]  D. Rossi,et al.  Astrocytes in Motor Neuron Diseases. , 2019, Advances in experimental medicine and biology.

[52]  K. Yamanaka,et al.  The multi-dimensional roles of astrocytes in ALS , 2018, Neuroscience Research.