Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

[1]  Linda Chang,et al.  Gray matter maturation and cognition in children with different APOE ε genotypes , 2016, Neurology.

[2]  X. Li,et al.  Electroacupuncture improves cognitive ability following cerebral ischemia reperfusion injury via CaM-CaMKIV-CREB signaling in the rat hippocampus. , 2016, Experimental and therapeutic medicine.

[3]  Yoshimi Kawamura,et al.  Tumour resistance in induced pluripotent stem cells derived from naked mole-rats , 2016, Nature Communications.

[4]  M. Figueres-Oñate,et al.  Adult Olfactory Bulb Interneuron Phenotypes Identified by Targeting Embryonic and Postnatal Neural Progenitors , 2016, Front. Neurosci..

[5]  Ben A. Barres,et al.  Complement and microglia mediate early synapse loss in Alzheimer mouse models , 2016, Science.

[6]  B. Davidson,et al.  PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo , 2016, Neuron.

[7]  K. Khodakhah,et al.  Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease , 2016, Proceedings of the National Academy of Sciences.

[8]  Raymond R. Tice,et al.  Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes , 2016, Brain Research.

[9]  Jon T. Brown,et al.  Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. , 2016, American journal of physiology. Cell physiology.

[10]  Giovanni Coppola,et al.  Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice , 2016, Nature Neuroscience.

[11]  S. Mooney,et al.  Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells , 2015, Stem cell reports.

[12]  Z. Weng,et al.  RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression , 2015, PloS one.

[13]  Zachary Glass,et al.  Altered Hippocampal Neurogenesis and Amygdalar Neuronal Activity in Adult Mice with Repeated Experience of Aggression , 2015, Front. Neurosci..

[14]  Su-jin Kim,et al.  Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation. , 2015, Biochimica et biophysica acta.

[15]  M. D. Del Bigio,et al.  Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells. , 2015, Nanomedicine : nanotechnology, biology, and medicine.

[16]  Karl J. Friston,et al.  Basal ganglia‐cortical structural connectivity in Huntington's disease , 2015, Human brain mapping.

[17]  M. Baudry,et al.  Imbalanced Mechanistic Target of Rapamycin C1 and C2 Activity in the Cerebellum of Angelman Syndrome Mice Impairs Motor Function , 2015, The Journal of Neuroscience.

[18]  C. Néri,et al.  Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice. , 2015, Human molecular genetics.

[19]  M. Hayden,et al.  HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. , 2015, Human molecular genetics.

[20]  Z. Weng,et al.  Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. , 2015, Human molecular genetics.

[21]  R. Faull,et al.  The diversity of GABA(A) receptor subunit distribution in the normal and Huntington's disease human brain. , 2015, Advances in pharmacology.

[22]  Kelly E. Glajch,et al.  Epigenetic Mechanisms Involved in Huntington's Disease Pathogenesis. , 2015, Journal of Huntington's disease.

[23]  J. Ericson,et al.  Tgfβ Signaling Regulates Temporal Neurogenesis and Potency of Neural Stem Cells in the CNS , 2014, Neuron.

[24]  R. Barker,et al.  Molecular and functional definition of the developing human striatum , 2014, Nature Neuroscience.

[25]  K. Tao,et al.  Talpid3-Binding Centrosomal Protein Cep120 Is Required for Centriole Duplication and Proliferation of Cerebellar Granule Neuron Progenitors , 2014, PloS one.

[26]  F. Niccolini,et al.  Neuroimaging in Huntington's disease. , 2014, World journal of radiology.

[27]  S. Finkbeiner,et al.  Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models , 2014, Nature chemical biology.

[28]  H. Okano,et al.  Modeling human neurological disorders with induced pluripotent stem cells , 2014, Journal of neurochemistry.

[29]  C. Svendsen,et al.  Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats , 2014, Neuroreport.

[30]  Jane S. Paulsen,et al.  Huntington disease: natural history, biomarkers and prospects for therapeutics , 2014, Nature Reviews Neurology.

[31]  David K. Gifford,et al.  Universal Count Correction for High-Throughput Sequencing , 2014, PLoS Comput. Biol..

[32]  Samuel Bernard,et al.  Neurogenesis in the Striatum of the Adult Human Brain , 2014, Cell.

[33]  J. Schisler,et al.  Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP. , 2014, Human molecular genetics.

[34]  M. Cookson,et al.  Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies , 2014, The Journal of Neuroscience.

[35]  John F. Wesseling,et al.  Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models , 2013, Nature Medicine.

[36]  E. Fraenkel,et al.  Targeting H3K4 trimethylation in Huntington disease , 2013, Proceedings of the National Academy of Sciences.

[37]  Andrew J Schwab,et al.  EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. , 2013, Stem cell research.

[38]  J. Schneider,et al.  Neural Stem Cells, Excited , 2013, Science.

[39]  Stéphane Lehéricy,et al.  Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy , 2011, Human brain mapping.

[40]  Jane S. Paulsen,et al.  Regional atrophy associated with cognitive and motor function in prodromal Huntington disease. , 2013, Journal of Huntington's disease.

[41]  D. Melton,et al.  Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme , 2012, Nature.

[42]  Jeffrey W. Streb,et al.  REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells , 2012, Development.

[43]  K. Marder,et al.  Development and neurodegeneration , 2012, Neurology.

[44]  Jessica K. Lee,et al.  Measures of growth in children at risk for Huntington disease , 2012, Neurology.

[45]  T. Gillis,et al.  Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. , 2012, Cell stem cell.

[46]  C. Svendsen,et al.  Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy , 2012, PloS one.

[47]  E. Ward,et al.  Inhibitory receptors bind Angptls and support blood stem cells and leukemia development , 2012, Nature.

[48]  Jan Sijbers,et al.  Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment , 2012, NeuroImage.

[49]  S. Orkin,et al.  METHOD Open Access , 2014 .

[50]  M. Greenberg,et al.  Neuronal activity-regulated gene transcription in synapse development and cognitive function. , 2011, Cold Spring Harbor perspectives in biology.

[51]  Yasuko Matsumura,et al.  A more efficient method to generate integration-free human iPS cells , 2011, Nature Methods.

[52]  Jeanne F. Loring,et al.  A call for standardized naming and reporting of human ESC and iPSC lines. , 2011, Cell stem cell.

[53]  M. Curtis,et al.  Neurogenesis in humans , 2011, The European journal of neuroscience.

[54]  Bernhard M. Schuldt,et al.  A bioinformatic assay for pluripotency in human cells , 2011, Nature Methods.

[55]  P. Brundin,et al.  Neurogenesis in the R6/2 mouse model of Huntington's disease is impaired at the level of NeuroD1 , 2011, Neuroscience.

[56]  Peter J. Park,et al.  An assessment of histone-modification antibody quality , 2010, Nature Structural &Molecular Biology.

[57]  Rory Johnson,et al.  The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease , 2010, Neurobiology of Disease.

[58]  G. Bashaw,et al.  Signaling from axon guidance receptors. , 2010, Cold Spring Harbor perspectives in biology.

[59]  M. Mehler,et al.  Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease , 2009, Proceedings of the National Academy of Sciences.

[60]  Martin Vingron,et al.  CpG-depleted promoters harbor tissue-specific transcription factor binding signals—implications for motif overrepresentation analyses , 2009, Nucleic acids research.

[61]  K. Nave,et al.  Neurod1 is essential for the survival and maturation of adult-born neurons , 2009, Nature Neuroscience.

[62]  Matthew T. Lorincz,et al.  Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells , 2009, Molecular and Cellular Neuroscience.

[63]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[64]  I. Bezprozvanny,et al.  Small-molecule activation of neuronal cell fate. , 2008, Nature chemical biology.

[65]  Mudita Singhal,et al.  Enabling high-throughput data management for systems biology: The Bioinformatics Resource Manager , 2007, Bioinform..

[66]  G. Lynch,et al.  LTP consolidation: Substrates, explanatory power, and functional significance , 2007, Neuropharmacology.

[67]  Ernest Fraenkel,et al.  Sequence analysis A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data , 2006 .

[68]  Gail Mandel,et al.  Reciprocal actions of REST and a microRNA promote neuronal identity , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[69]  F. Gage,et al.  Chromatin remodeling in neural development and plasticity. , 2005, Current opinion in cell biology.

[70]  B. Harper.  Huntington Disease , 2005, Journal of the Royal Society of Medicine.

[71]  R. Faull,et al.  A histochemical and immunohistochemical analysis of the subependymal layer in the normal and Huntington's disease brain , 2005, Journal of Chemical Neuroanatomy.

[72]  Mark R. Segal,et al.  Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death , 2004, Nature.

[73]  Karen Marder,et al.  Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[74]  Cathryn M Lewis,et al.  Standardization and statistical approaches to therapeutic trials in the R6/2 mouse , 2003, Brain Research Bulletin.

[75]  A. Hartmann,et al.  Changes in GAD67 mRNA expression evidenced by in situ hybridization in the brain of R6/2 transgenic mice , 2003, Journal of neurochemistry.

[76]  E. Marcora,et al.  Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[77]  Michael Dragunow,et al.  Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[78]  C. Kintner,et al.  Neurogenesis in Embryos and in Adult Neural Stem Cells , 2002, The Journal of Neuroscience.

[79]  John Quackenbush,et al.  Genesis: cluster analysis of microarray data , 2002, Bioinform..

[80]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[81]  Johannes Gerdes,et al.  The Ki‐67 protein: From the known and the unknown , 2000, Journal of cellular physiology.

[82]  R. Prayson,et al.  Evaluation of epithelial and keratin markers in glioblastoma multiforme: an immunohistochemical study. , 1999, Archives of pathology & laboratory medicine.

[83]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[84]  Y. Imai,et al.  A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. , 1996, Biochemical and biophysical research communications.

[85]  Holger Karas,et al.  TRANSFAC: a database on transcription factors and their DNA binding sites , 1996, Nucleic Acids Res..

[86]  N W Kowall,et al.  Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[87]  K. A. Wall,et al.  A monoclonal antibody against the type II isotype of beta-tubulin. Preparation of isotypically altered tubulin. , 1988, The Journal of biological chemistry.

[88]  E. Reske‐Nielsen,et al.  Astrocytes in the prenatal central nervous system. From 5th to 28th week of gestation. An immunohistochemical study on paraffin-embedded material. , 2009, Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology.

[89]  A. Frankfurter,et al.  Differential Localization of MAP‐2 and Tau in Mammalian Neurons in Situ a , 1986, Annals of the New York Academy of Sciences.