Novel focused OCT-LIF endoscope

Combined optical coherence tomography (OCT) and laser-induced fluorescence (LIF) endoscopy has shown higher sensitivity and specificity for distinguishing normal tissue from adenoma when compared to either modality alone. Endoscope optical design is complicated by the large wavelength difference between the two systems. A new high-resolution endoscope 2 mm in diameter is presented that can create focused beams from the ultraviolet to near-infrared. A reflective design ball lens operates achromatically over a large wavelength range, and employs TIR at two faces and reflection at a third internal mirrored face. The 1:1 imaging system obtains theoretically diffraction-limited spots for both the OCT (1300 nm) and LIF (325 nm) channels.

[1]  M Fitzmaurice,et al.  Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306–310 nm excitation , 1990, Lasers in surgery and medicine.

[2]  Cheong Hoong Diong,et al.  Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression , 2001, European Conference on Biomedical Optics.

[3]  R. Rava,et al.  SPECTROSCOPIC DIAGNOSIS OF COLONIC DYSPLASIA , 1991, Photochemistry and photobiology.

[4]  J. Davis,et al.  Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis , 2010, Cancer biology & therapy.

[5]  J. Izatt,et al.  In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography. , 1997, Optics letters.

[6]  Yuan Luo,et al.  Laser-induced fluorescence imaging of subsurface tissue structures with a volume holographic spatial-spectral imaging system. , 2008, Optics letters.

[7]  Characterization of human coronary artery atherosclerotic plaque fluorescence emission. , 1990, The Canadian journal of cardiology.

[8]  Urs Utzinger,et al.  Task-based imaging of colon cancer in the Apc(Min/+) mouse model. , 2006, Applied optics.

[9]  T. J. Pfefer,et al.  Influence of illumination-collection geometry on fluorescence spectroscopy in multilayer tissue , 2006, Medical and Biological Engineering and Computing.

[10]  Qin Huang,et al.  Three-dimensional endomicroscopy of the human colon using optical coherence tomography. , 2009, Optics express.

[11]  N. Woodhouse.  The Propagation of Light , 2003 .

[12]  Angelika Unterhuber,et al.  Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography , 2007, Cancer biology & therapy.

[13]  Andrew L. Alexander,et al.  Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy , 1994 .

[14]  R. Prosst,et al.  Fluorescence diagnosis of colorectal neoplasms: a review of clinical applications , 2002, International Journal of Colorectal Disease.

[15]  Elizabeth M. Kanter,et al.  Dual Modality Imaging of a Novel Rat Model of Ovarian Carcinogenesis , 2022 .

[16]  Robert Rennie Shannon,et al.  The Art and Science of Optical Design , 1997 .

[17]  V Westphal,et al.  High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS. , 2001, Gastrointestinal endoscopy.

[18]  Byeong Ha Lee,et al.  Combined system of optical coherence tomography and fluorescence spectroscopy based on double-cladding fiber. , 2008, Optics letters.

[19]  B. Wilson,et al.  Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract , 2010, Lasers in surgery and medicine.

[20]  N. Ramanujam.  Fluorescence spectroscopy of neoplastic and non-neoplastic tissues. , 2000, Neoplasia.

[21]  T Joshua Pfefer,et al.  Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design. , 2003, Optics letters.

[22]  H. Azhari.  Special Imaging Techniques , 2010 .

[23]  Urs Utzinger,et al.  Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement. , 2004, Applied optics.

[24]  Natalia M. Shakhova,et al.  Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes , 2002 .

[25]  T Joshua Pfefer,et al.  Multiple-fiber probe design for fluorescence spectroscopy in tissue. , 2002, Applied optics.

[26]  Jennifer K. Barton,et al.  Combined Endoscopic Optical Coherence Tomography and Laser Induced Fluorescence , 2008 .

[27]  U. Utzinger,et al.  Endoscopic optical coherence tomography and laser‐induced fluorescence spectroscopy in a murine colon cancer model , 2006, Lasers in surgery and medicine.

[28]  Urs Utzinger,et al.  Ex vivo optical coherence tomography and laser induced fluorescence spectroscopy imaging of murine gastrointestinal tract , 2005, SPIE BiOS.

[29]  B. Bouma,et al.  Handbook of Optical Coherence Tomography , 2001 .

[30]  M. Hassan,et al.  Biomedical applications of fluorescence imaging in vivo. , 2004, Comparative medicine.

[31]  Steven W. Smith.  CHAPTER 25 – Special Imaging Techniques , 2002 .

[32]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[33]  G. Gelikonov,et al.  Endoscopic OCT with forward‐looking probe: clinical studies in urology and gastroenterology , 2008, Journal of biophotonics.

[34]  J. Izatt,et al.  High-resolution endoscopic imaging of the GI tract using optical coherence tomography. , 2000, Gastrointestinal endoscopy.

[35]  W. Drexler,et al.  In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope. , 2006, Journal of biomedical optics.