Cytomegalovirus colitis in a child with leukemia: a case report.

A 17-month-old boy with a known case of T-cell acute lymphoblastic leukemia was admitted to the authors' hospital because of blood-streaked diarrhea a week after his last chemotherapy session. Initially, he was treated with supportive care and an empiric regimen for opportunistic causes of diarrhea; however, this was not effective. Eventually, evaluation of his stool with PCR showed positivity for cytomegalovirus. Consequently, he responded dramatically to treatment with ganciclovir. Although cytomegalovirus colitis is rare, a few case reports suggest cytomegalovirus as a possible cause of colitis in children with leukemia, which can be fatal and should be considered as a differential diagnosis.

[1]  Canyang Zhan,et al.  Predictive significance of neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte for cytomegalovirus infection in infants less than 3 months: A retrospective study , 2021, Journal of clinical laboratory analysis.

[2]  Tejabhiram Yadavalli,et al.  Cytomegalovirus Retinitis in HIV and Non-HIV Individuals , 2019, Microorganisms.

[3]  Steven E Roskos,et al.  Cytomegalovirus infection in immunocompetent adults: Is observation still the best strategy? , 2018, IDCases.

[4]  A. Trehan,et al.  Cytomegalovirus disease in children with acute lymphoblastic leukemia , 2016, Pediatric hematology and oncology.

[5]  D. Gaya,et al.  Catastrophic gastrointestinal complication of systemic immunosuppression. , 2015, World journal of gastroenterology.

[6]  G. Dbaibo,et al.  Cytomegalovirus retinitis in children and young adults with acute lymphoblastic leukemia in Lebanon , 2014, Leukemia & lymphoma.

[7]  H. Moritake,et al.  Cytomegalovirus retinitis as an adverse immunological effect of pulses of vincristine and dexamethasone in maintenance therapy for childhood acute lymphoblastic leukemia , 2013, Pediatric blood & cancer.

[8]  C. Kotton CMV: Prevention, Diagnosis and Therapy , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[9]  Yung-Chih Wang,et al.  Risk factors and outcomes of cytomegalovirus viremia in cancer patients: a study from a medical center in northern Taiwan. , 2011, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[10]  O. Devecioğlu,et al.  Pediatric acute lymphoblastic leukemia complicated by secondary hemophagocytic lymphohistiocytosis , 2009, Pediatric blood & cancer.

[11]  E. Oldfield,et al.  Gastrointestinal cytomegalovirus disease in the immunocompromised patient , 2008, Current gastroenterology reports.

[12]  D. Kontoyiannis,et al.  Gastrointestinal cytomegalovirus disease in patients with cancer: a two decade experience in a tertiary care cancer center. , 2005, European journal of cancer.

[13]  M. Miyahara,et al.  Successful treatment of cytomegalovirus colitis with ganciclovir in a patient with adult T cell leukemia lymphoma: case report. , 1999, Journal of chemotherapy.

[14]  F. Buckner,et al.  Cytomegalovirus disease of the gastrointestinal tract in patients without AIDS. , 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.