Measuring primate RNFL thickness with OCT

We report results of a study using optical coherence tomography (OCT) to create area maps of the retinal nerve fiber layer (RNFL) thickness. Low-resolution B scans (two-dimensional images) of the in vivo rhesus monkey retina have been recorded in the optic disk, peripapillary area, and macula. Three-dimensional (3-D) renderings of these areas have been created from OCT images and compared to corresponding data from histology. Results of our study indicate: (1) OCT may be utilized to measure the retinal nerve fiber layer thickness in vivo and (2) 3-D surface maps accurately depict the anatomy of the RNFL.

[1]  R. Radius.  Thickness of the retinal nerve fiber layer in primate eyes. , 1980, Archives of ophthalmology.

[2]  E A Swanson,et al.  Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. , 1995, Archives of ophthalmology.

[3]  Larger optic nerve heads have more nerve fibers in normal monkey eyes. , 1992, Archives of ophthalmology.

[4]  A. Sommer,et al.  Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. , 1991, Archives of ophthalmology.

[5]  Thomas E. Ogden,et al.  Nerve fiber layer of the primate retina: Thickness and glial content , 1983, Vision Research.

[6]  T. Ogden.  Nerve fiber layer of the primate retina: morphometric analysis. , 1984, Investigative ophthalmology & visual science.

[7]  R. Weinreb,et al.  Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness. , 1990, Archives of ophthalmology.

[8]  Henry Grady Rylander,et al.  Imaging the primate retina using polarization-sensitve optical coherence tomography , 2001, SPIE BiOS.

[9]  J. Jonas,et al.  Retinal nerve fiber layer thickness in human eyes , 1999, Graefe's Archive for Clinical and Experimental Ophthalmology.

[10]  R Varma,et al.  Retinal nerve fiber layer thickness in normal human eyes. , 1996, Ophthalmology.

[11]  L. Zangwill,et al.  A comparison of optical coherence tomography and retinal nerve fiber layer photography for detection of nerve fiber layer damage in glaucoma. , 2000, Ophthalmology.