pathogenesispathophysiology: current concepts of

[1]  James G Krueger,et al.  Potential Role of the Chemokine Receptors CXCR3, CCR4, and the Integrin αEβ7 in the Pathogenesis of Psoriasis Vulgaris , 2001, Laboratory Investigation.

[2]  M. Dhodapkar,et al.  Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris , 2004, The Journal of experimental medicine.

[3]  G. Hartmann,et al.  Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. , 2002, The Journal of investigative dermatology.

[4]  P. Lenz,et al.  IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity , 2003, The Journal of Immunology.

[5]  L. Kovarova,et al.  Generation of antigen-loaded dendritic cells in a serum-free medium using different cytokine combinations. , 2003, Vaccine.

[6]  H. Okamura,et al.  IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells , 2000 .

[7]  R. Pine.  Convergence of TNFα and IFNγ signalling pathways through synergistic induction of IRF-1/ISGF-2 is mediated by a composite GAS/κB promoter element , 1997 .

[8]  Yong‐jun Liu,et al.  Mouse and human dendritic cell subtypes , 2002, Nature Reviews Immunology.

[9]  Jurg Ott,et al.  A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis , 2003, Nature Genetics.

[10]  T. Bieber,et al.  Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema. , 1996, The Journal of investigative dermatology.

[11]  D. Gladman,et al.  CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis. , 2003, American journal of human genetics.

[12]  S. Porcelli,et al.  Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells1 , 2000, The Journal of Immunology.

[13]  G. Yancopoulos,et al.  Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. , 2003, Blood.

[14]  M. Lebwohl,et al.  A novel targeted T-cell modulator, efalizumab, for plaque psoriasis. , 2003, The New England journal of medicine.

[15]  A. Menter,et al.  Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial. , 2003, JAMA.

[16]  E. Weinman.  New functions for the NHERF family of proteins. , 2001, The Journal of clinical investigation.

[17]  U. Boehm,et al.  Cellular responses to interferon-gamma. , 1997, Annual review of immunology.

[18]  J. McGregor,et al.  Epidermal dendritic cells in psoriasis possess a phenotype associated with antigen presentation: in situ expression of beta 2-integrins. , 1992, Journal of the American Academy of Dermatology.

[19]  G. Krueger,et al.  Development and use of alefacept to treat psoriasis. , 2003, Journal of the American Academy of Dermatology.

[20]  C. Thompson,et al.  Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. , 1993, Journal of immunology.

[21]  S. Shenolikar,et al.  NHERF: targeting and trafficking membrane proteins. , 2001, American journal of physiology. Renal physiology.

[22]  Yusuke Nakamura,et al.  An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis , 2003, Nature Genetics.

[23]  Albert Francis Blakeslee,et al.  Department of Genetics , 1941 .

[24]  M. Miyazaki,et al.  Cutting Edge: Negative Regulation of Immune Synapse Formation by Anchoring Lipid Raft to Cytoskeleton Through Cbp-EBP50-ERM Assembly1 , 2002, The Journal of Immunology.

[25]  A. Gottlieb,et al.  Infliximab monotherapy provides rapid and sustained benefit for plaque-type psoriasis. , 2003, Journal of the American Academy of Dermatology.

[26]  J. Kieffer,et al.  Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells , 1997, Nature.

[27]  T. Nomura,et al.  Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice , 2003, Nature.

[28]  J Wagner,et al.  Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. , 2000, Immunity.

[29]  R. Abraham,et al.  Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002. , 1996, The EMBO journal.

[30]  J. Kieffer,et al.  Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40. , 2001, The Journal of investigative dermatology.

[31]  J. Krueger.  The immunologic basis for the treatment of psoriasis with new biologic agents. , 2002, Journal of the American Academy of Dermatology.

[32]  A. Bowcock,et al.  The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. , 2004, Human molecular genetics.

[33]  L. Austin,et al.  CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. , 2000, Journal of autoimmunity.

[34]  Wing Hung Wong,et al.  Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. , 2003, Physiological genomics.

[35]  Frank O. Nestle,et al.  Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α , 2004, The Journal of experimental medicine.

[36]  K. Urabe,et al.  In situ Localization of CD83-Positive Dendritic Cells in Psoriatic Lesions , 2002, Dermatology.

[37]  A. Bowcock,et al.  Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. , 1994, Science.

[38]  F. Nestle,et al.  Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. , 1994, The Journal of clinical investigation.

[39]  A. Gottlieb,et al.  Etanercept as monotherapy in patients with psoriasis. , 2003, The New England journal of medicine.

[40]  D. Gudbjartsson,et al.  A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting. , 2003, American journal of human genetics.

[41]  H. Tagami,et al.  Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses , 2002, Archives of Dermatological Research.

[42]  A. Roses,et al.  Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map. , 2002, Genomics.

[43]  Jens Holmberg,et al.  Positional identification of Ncf1 as a gene that regulates arthritis severity in rats , 2003, Nature Genetics.

[44]  R. Jonsson,et al.  A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans , 2002, Nature Genetics.

[45]  A. Gottlieb,et al.  TNF-alpha and apoptosis: implications for the pathogenesis and treatment of psoriasis. , 2002, Journal of drugs in dermatology : JDD.

[46]  James G. Krueger,et al.  Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis , 1995, Nature Genetics.

[47]  James T. Elder,et al.  Genetic epidemiology of psoriasis and psoriatic arthritis , 2005, Annals of the rheumatic diseases.

[48]  P. Parren,et al.  Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model. , 2003, The Journal of clinical investigation.