Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1

[1]  K. Mori,et al.  Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress , 2006, Molecular and Cellular Biology.

[2]  P. Walter,et al.  Intracellular signaling by the unfolded protein response. , 2006, Annual review of cell and developmental biology.

[3]  M. Katze,et al.  Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload , 2006, Cell.

[4]  Amy S. Lee,et al.  GRP78/BiP Is Required for Cell Proliferation and Protecting the Inner Cell Mass from Apoptosis during Early Mouse Embryonic Development , 2006, Molecular and Cellular Biology.

[5]  Jonathan S Weissman,et al.  Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response , 2006, Science.

[6]  E. Hartmann,et al.  Deletion of SERP1/RAMP4, a Component of the Endoplasmic Reticulum (ER) Translocation Sites, Leads to ER Stress , 2006, Molecular and Cellular Biology.

[7]  J. Weissman,et al.  Molecular Chaperones and Protein Quality Control , 2006, Cell.

[8]  R. Kaufman,et al.  Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation , 2006, The Journal of cell biology.

[9]  Kenjiro Sakaki,et al.  Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans , 2005, PLoS genetics.

[10]  R. Kaufman,et al.  Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. , 2004, Journal of biochemistry.

[11]  D. Thuerauf,et al.  Opposing Roles for ATF6α and ATF6β in Endoplasmic Reticulum Stress Response Gene Induction* , 2004, Journal of Biological Chemistry.

[12]  Y. Nomura,et al.  ER signaling in unfolded protein response. , 2003, Life sciences.

[13]  L. Glimcher,et al.  XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response , 2003, Molecular and Cellular Biology.

[14]  K. Mori Frame Switch Splicing and Regulated Intramembrane Proteolysis: Key Words to Understand the Unfolded Protein Response , 2003, Traffic.

[15]  N. Hirokawa,et al.  Kinesin Superfamily Protein 2A (KIF2A) Functions in Suppression of Collateral Branch Extension , 2003, Cell.

[16]  R. Paules,et al.  An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. , 2003, Molecular cell.

[17]  Hiderou Yoshida,et al.  A time-dependent phase shift in the mammalian unfolded protein response. , 2003, Developmental cell.

[18]  K. Mori,et al.  Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. , 2002, The Biochemical journal.

[19]  L. Hendershot,et al.  Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. , 2002, Journal of molecular biology.

[20]  Hiderou Yoshida,et al.  IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. , 2002, Genes & development.

[21]  K. Mori,et al.  XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor , 2001, Cell.

[22]  E McEwen,et al.  Translational control is required for the unfolded protein response and in vivo glucose homeostasis. , 2001, Molecular cell.

[23]  D. Ron,et al.  Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. , 2001, Molecular cell.

[24]  D. Ron,et al.  Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α , 2001, The Journal of cell biology.

[25]  K. Mori,et al.  Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. , 2001, The Biochemical journal.

[26]  T. Miyata,et al.  Identification of ERSE-II, a New cis-Acting Element Responsible for the ATF6-dependent Mammalian Unfolded Protein Response* , 2001, The Journal of Biological Chemistry.

[27]  Judy H. Cho,et al.  Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. , 2001, The Journal of clinical investigation.

[28]  K. Mori,et al.  Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response , 2001, Molecular and Cellular Biology.

[29]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[30]  X. Chen,et al.  ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. , 2000, Molecular cell.

[31]  M. Schapira,et al.  Regulated translation initiation controls stress-induced gene expression in mammalian cells. , 2000, Molecular cell.

[32]  R. Kaufman,et al.  Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. , 2000, The Journal of biological chemistry.

[33]  S. Schuster,et al.  Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. , 2000, The Journal of biological chemistry.

[34]  Hiderou Yoshida,et al.  ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response , 2000, Molecular and Cellular Biology.

[35]  K. Mori Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum , 2000, Cell.

[36]  D. Ron,et al.  Perk is essential for translational regulation and cell survival during the unfolded protein response. , 2000, Molecular cell.

[37]  F. Urano,et al.  Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. , 2000, Science.

[38]  S. Orkin,et al.  An essential role in liver development for transcription factor XBP-1. , 2000, Genes & development.

[39]  K. Mori,et al.  Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. , 1999, Molecular biology of the cell.

[40]  R. Kaufman,et al.  Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. , 1999, Genes & development.

[41]  Hiderou Yoshida,et al.  Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins , 1998, The Journal of Biological Chemistry.

[42]  N. Hirokawa,et al.  Altered microtubule organization in small-calibre axons of mice lacking tau protein , 1994, Nature.

[43]  K. Mori,et al.  Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation. , 2006, Cell structure and function.