Validation of IKKb as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKKb to pulmonary epithelial cells
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[1] E. Alnemri,et al. In vitro activation of CPP 32 and Mch 3 by Mch 4 , a novel human apoptotic cysteine protease containing two FADD-like domains ( granzyme B / Mch 2 / protease cascade / FAS / APO-I-receptor ) , 2005 .
[2] A. Scovassi,et al. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update , 2002, Apoptosis.
[3] B. Strahl,et al. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. , 2003, Nature.
[4] R. Gaynor,et al. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. , 2003, Nature.
[5] P. Barnes,et al. IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. , 2003, FEBS letters.
[6] G. Courtois,et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 , 2002, Nature.
[7] E. Andreakos,et al. Nuclear factor-kappaB activation in alveolar macrophages requires IkappaB kinase-beta, but not nuclear factor-kappaB inducing kinase. , 2002, American journal of respiratory and critical care medicine.
[8] Michael Karin,et al. NF-kappaB at the crossroads of life and death. , 2002, Nature immunology.
[9] G. W. Peet,et al. IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. , 2002, The Journal of biological chemistry.
[10] R. Orlowski,et al. NF-kappaB as a therapeutic target in cancer. , 2002, Trends in molecular medicine.
[11] J. Hoffmann,et al. Toll receptors in innate immunity. , 2001, Trends in cell biology.
[12] S. Akira,et al. Brief Definitive Report Essential Role of Nuclear Factor (nf)- B–inducing Kinase and Inhibitor of B (i B) Kinase ␣ in Nf- B Activation through Lymphotoxin  Receptor, but Not through Tumor Necrosis Factor Receptor I , 2022 .
[13] M. Karin,et al. IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. , 2001, Immunity.
[14] Y. Minemoto,et al. Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. , 2001, Molecular cell.
[15] J Bousquet,et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. , 2000, American journal of respiratory and critical care medicine.
[16] P. Barnes,et al. Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1beta, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms. , 2000, American journal of respiratory cell and molecular biology.
[17] P. Barnes. Therapeutic strategies for allergic diseases , 1999, Nature.
[18] Y. Nasuhara,et al. Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription. , 1999, The Journal of biological chemistry.
[19] L. Miraglia,et al. Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-α Expression* , 1999, The Journal of Biological Chemistry.
[20] I. Verma,et al. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. , 1999, Science.
[21] G. de Murcia,et al. Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis , 1998, The Journal of Biological Chemistry.
[22] E. Zandi,et al. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. , 1997, Cell.
[23] D B Young,et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. , 1997, Science.
[24] C. Scheidereit,et al. Different mechanisms control signal‐induced degradation and basal turnover of the NF‐kappaB inhibitor IkappaB alpha in vivo. , 1996, The EMBO journal.
[25] S. Srinivasula,et al. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[26] I. Adcock,et al. Superinduction of NF-kappa B by actinomycin D and cycloheximide in epithelial cells. , 1996, Biochemical and biophysical research communications.
[27] E. Alnemri,et al. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. , 1994, The Journal of biological chemistry.
[28] J. Vane,et al. Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone , 1994, British journal of pharmacology.
[29] K. Johnson. An Update. , 1984, Journal of food protection.