The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease.

[1]  M. Barbagallo,et al.  Extra virgin olive oil improves learning and memory in SAMP8 mice. , 2012, Journal of Alzheimer's disease : JAD.

[2]  A. Palmeri,et al.  Endogenous amyloid‐β is necessary for hippocampal synaptic plasticity and memory , 2011, Annals of neurology.

[3]  D. Butterfield,et al.  Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor proteinΞ , 2011, Neuroscience.

[4]  D. Gokhman,et al.  Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease. , 2011, CNS & neurological disorders drug targets.

[5]  L. Lue,et al.  Inhibition of Amyloid-β (Aβ) Peptide-Binding Alcohol Dehydrogenase-Aβ Interaction Reduces Aβ Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease , 2011, The Journal of Neuroscience.

[6]  D. Butterfield,et al.  Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease , 2011, Free radical research.

[7]  José A. García,et al.  Melatonin-mitochondria interplay in health and disease. , 2011, Current topics in medicinal chemistry.

[8]  Xiang-Lei Peng,et al.  Administration of amyloid-β42 oligomer-specific monoclonal antibody improved memory performance in SAMP8 mice. , 2011, Journal of Alzheimer's disease : JAD.

[9]  J. Morley.  Alzheimer's disease: future treatments. , 2011, Journal of the American Medical Directors Association.

[10]  J. del Valle,et al.  Characterization of amyloid-β granules in the hippocampus of SAMP8 mice. , 2011, Journal of Alzheimer's Disease.

[11]  S. M. Robinson,et al.  Impairments in brain-to-blood transport of amyloid-β and reabsorption of cerebrospinal fluid in an animal model of Alzheimer's disease are reversed by antisense directed against amyloid-β protein precursor. , 2011, Journal of Alzheimer's disease : JAD.

[12]  Roman Kireev,et al.  Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8) , 2010, Experimental Gerontology.

[13]  D. Butterfield,et al.  Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. , 2010, Free radical biology & medicine.

[14]  G. McKhann,et al.  Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model , 2010, Proceedings of the National Academy of Sciences.

[15]  M. Mattson,et al.  The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice , 2010, Experimental Neurology.

[16]  C. Rodolfo,et al.  Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases , 2010, Expert review of proteomics.

[17]  D. Yew,et al.  Analysis of Neuronal Nitric Oxide Synthase Expression and Increasing Astrogliosis in the Brain of Senescence-Accelerated-Prone 8 Mice , 2010, The International journal of neuroscience.

[18]  G. Yen,et al.  Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease. , 2010, The Journal of nutritional biochemistry.

[19]  G. Du,et al.  Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice , 2010, Brain Research.

[20]  A. Eckert,et al.  Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects , 2010, Molecular Neurobiology.

[21]  W. Banks,et al.  A Physiological Role for Amyloid-β Protein: Enhancement of Learning and Memory , 2010 .

[22]  C. Moraes,et al.  What role does mitochondrial stress play in neurodegenerative diseases? , 2010, Methods in molecular biology.

[23]  J. Morley,et al.  Bioavailable testosterone predicts a lower risk of Alzheimer's disease in older men. , 2010, Journal of Alzheimer's disease : JAD.

[24]  Mark A. Smith,et al.  NMR studies of zinc, copper, and iron binding to histidine, the principal metal ion complexing site of amyloid-beta peptide. , 2010, Journal of Alzheimer's Disease.

[25]  D. Butterfield,et al.  Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism , 2009, Journal of neurochemistry.

[26]  W. Banks,et al.  Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[27]  D. Butterfield,et al.  Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment , 2009, Journal of bioenergetics and biomembranes.

[28]  D. Acuña-Castroviejo,et al.  Long‐term melatonin administration protects brain mitochondria from aging , 2009, Journal of pineal research.

[29]  B. Fischer,et al.  Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems. , 2009, Biochemistry.

[30]  W. Banks,et al.  Increase in Presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing , 2009, Journal of Experimental Biology.

[31]  A. Palmeri,et al.  Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus , 2008, The Journal of Neuroscience.

[32]  Liegang Liu,et al.  Ameliorative effects of lotus seedpod proanthocyanidins on cognitive deficits and oxidative damage in senescence-accelerated mice , 2008, Behavioural Brain Research.

[33]  W. Banks,et al.  Effect of dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning ability, and memory of senescence-accelerated mouse. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  I. Vega-Naredo,et al.  Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence‐accelerated mice , 2008, Journal of pineal research.

[35]  M. Pallàs,et al.  Dysfunction of astrocytes in senescence‐accelerated mice SAMP8 reduces their neuroprotective capacity , 2008, Aging cell.

[36]  José A. García,et al.  Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice , 2008, Experimental Gerontology.

[37]  Leung-Wing Chu,et al.  Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men , 2008, Clinical endocrinology.

[38]  W. Fan,et al.  Differential effects of melatonin on hippocampal neurodegeneration in different aged accelerated senescence prone mouse-8. , 2008, Neuro endocrinology letters.

[39]  G. Perry,et al.  Alzheimer disease and the role of free radicals in the pathogenesis of the disease. , 2008, CNS & neurological disorders drug targets.

[40]  X. Tong,et al.  Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease , 2008, Experimental physiology.

[41]  G. Perry,et al.  From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8). , 2008, Journal of Alzheimer's disease : JAD.

[42]  Jiang-Ning Zhou,et al.  Age-related changes in anxiety are task-specific in the senescence-accelerated prone mouse 8 , 2007, Physiology & Behavior.

[43]  W. Banks,et al.  Anti-amyloid beta protein antibody passage across the blood–brain barrier in the SAMP8 mouse model of Alzheimer's disease: An age-related selective uptake with reversal of learning impairment , 2007, Experimental Neurology.

[44]  J. Morley,et al.  Lipid peroxidation in brain during aging in the senescence-accelerated mouse (SAM) , 2007, Neurobiology of Aging.

[45]  M. Pallàs,et al.  Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8 , 2007, Journal of pineal research.

[46]  R. Deane,et al.  Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. , 2007, Current Alzheimer research.

[47]  D. Dickson,et al.  Filling the Gaps in the Aβ Cascade Hypothesis of Alzheimers Disease , 2006 .

[48]  Ming-Fu Wang,et al.  Favorable effects of tea on reducing the cognitive deficits and brain morphological changes in senescence-accelerated mice. , 2006, Journal of nutritional science and vitaminology.

[49]  D. Butterfield,et al.  Redox proteomics identification of oxidatively modified proteins in Alzheimer's disease brain and in vivo and in vitro models of AD centered around Abeta(1-42). , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[50]  Y. Nomura,et al.  Antioxidative activity and ameliorative effects of memory impairment of sulfur‐containing compounds in Allium species , 2006, BioFactors.

[51]  M. Pallàs,et al.  Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM) , 2005, Mechanisms of Ageing and Development.

[52]  D. Butterfield,et al.  The senescence-accelerated prone mouse (SAMP8): A model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease , 2005, Experimental Gerontology.

[53]  D. Butterfield,et al.  Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein. , 2005, Brain research. Molecular brain research.

[54]  D. Yew,et al.  Age related changes of various markers of astrocytes in senescence-accelerated mice hippocampus , 2005, Neurochemistry International.

[55]  D. Butterfield,et al.  Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders , 2005, Neurochemistry International.

[56]  D. Butterfield,et al.  Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain , 2004, Neuroscience.

[57]  D. Butterfield,et al.  Antisense directed at the Aβ region of APP decreases brain oxidative markers in aged senescence accelerated mice , 2004, Brain Research.

[58]  M. Beal,et al.  Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[59]  J. Wegiel,et al.  Contribution of glial cells to the development of amyloid plaques in Alzheimer’s disease , 2004, Neurobiology of Aging.

[60]  R. Swerdlow,et al.  A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease. , 2004, Medical hypotheses.

[61]  H. Kimura,et al.  Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM) , 2004, Acta Neuropathologica.

[62]  J. Morley.  The SAMP8 mouse: a model of Alzheimer disease? , 2004, Biogerontology.

[63]  R. Martins,et al.  Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β , 2003, Brain Research Reviews.

[64]  J. Morley,et al.  Cholinergic deficits in the septal–hippocampal pathway of the SAM-P/8 senescence accelerated mouse , 2003, Brain Research.

[65]  D. Butterfield,et al.  The antioxidants α‐lipoic acid and N‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice , 2003, Journal of neurochemistry.

[66]  D. Butterfield,et al.  Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71 , 2002, Journal of neurochemistry.

[67]  J. Morley,et al.  Antibody to Amyloid β Protein Alleviates Impaired Acquisition, Retention, and Memory Processing in SAMP8 Mice , 2002, Neurobiology of Learning and Memory.

[68]  R. Reiter,et al.  Melatonin reduces oxidative damage of neural lipids and proteins in senescence-accelerated mouse , 2002, Neurobiology of Aging.

[69]  W. Banks,et al.  Alzheimer’s disease through the eye of a mouse Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson prize , 2002, Peptides.

[70]  D. Butterfield.  Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. , 2002, Free radical research.

[71]  K. Imaizumi,et al.  Learning behaviour and cerebral protein kinase C, antioxidant status, lipid composition in senescence-accelerated mouse: influence of a phosphatidylcholine–vitamin B12 diet , 2001, British Journal of Nutrition.

[72]  P. Ince,et al.  Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD , 2001, Neurology.

[73]  W. Banks,et al.  Delivery across the blood-brain barrier of antisense directed against amyloid beta: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein. , 2001, The Journal of pharmacology and experimental therapeutics.

[74]  J. Morley,et al.  β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory , 2000, Peptides.

[75]  W. Banks,et al.  Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice , 2000, Peptides.

[76]  J. Morley,et al.  Identification of age-dependent changes in expression of senescence-accelerated mouse (SAMP8) hippocampal proteins by expression array analysis. , 2000, Biochemical and biophysical research communications.

[77]  J. H. Choi,et al.  Effects of age and dietary restriction on lifespan and oxidative stress of SAMP8 mice with learning and memory impairments. , 2000, The journal of nutrition, health & aging.

[78]  M. Festing,et al.  Genetic typing of the Senescence-Accelerated Mouse (SAM) strains with microsatellite markers , 1999, Mammalian Genome.

[79]  D. Butterfield,et al.  Structural and Functional Changes in Proteins Induced by Free Radical‐mediated Oxidative Stress and Protective Action of the Antioxidants N‐tert‐Butyl‐α‐phenylnitrone and Vitamin E a , 1998 .

[80]  J. Morley,et al.  Age-related changes in septal serotonergic, GABAergic and glutamatergic facilitation of retention in SAMP8 mice , 1998, Mechanisms of Ageing and Development.

[81]  D. Ingram,et al.  Behavioral Assessment of the Senescence-accelerated Mouse (SAM P8 and R1) , 1998, Physiology & Behavior.

[82]  J. Morley,et al.  Learning and memory in the SAMP8 mouse , 1997, Neuroscience & Biobehavioral Reviews.

[83]  M. Miyamoto.  Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10 , 1997, Experimental Gerontology.

[84]  Y. Kitamura,et al.  Alterations in acetylcholine, NMDA, benzodiazepine receptors and protein kinase C in the brain of the senescence-accelerated mouse: an animal model useful for studies on cognitive enhancers , 1997, Behavioural Brain Research.

[85]  T. Kurokawa,et al.  Early appearance of abnormality of microperoxisomal enzymes in the cerebral cortex of senescence-accelerated mouse , 1996, Mechanisms of Ageing and Development.

[86]  J. Morley,et al.  Age-related changes in hippocampal drug facilitation of memory processing in SAMP 8 Mice , 1996, Neurobiology of Aging.

[87]  T. Kurokawa,et al.  Early and transient increase in oxidative stress in the cerebral cortex of senescence-accelerated mouse , 1996, Mechanisms of Ageing and Development.

[88]  J. Morley,et al.  Age-related changes in learning, memory, and lipofuscin as a function of the percentage of SAMP8 genes , 1995, Physiology & Behavior.

[89]  J. Morley,et al.  Age-related decrease of plasma testosterone in SAMP8 mice: Replacement improves age-related impairment of learning and memory , 1995, Physiology & Behavior.

[90]  J. Morley,et al.  Age-related impairment in learning but not memory in SAMP8 female mice , 1995, Pharmacology Biochemistry and Behavior.

[91]  N. Nishiyama,et al.  Ameliorative effects of chronic treatment using DX-9386, a traditional Chinese prescription, on learning performance and lipid peroxide content in senescence accelerated mouse. , 1994, Biological & pharmaceutical bulletin.

[92]  Akira Kato,et al.  Colocalization of prolyl endopeptidase and amyloid β-peptide in brains of senescence-accelerated mouse , 1994, Neuroscience Letters.

[93]  L. Butcher,et al.  Involvement of free oxygen radicals in β-amyloidosis: An hypothesis , 1994, Neurobiology of Aging.

[94]  D. Ingram,et al.  Age-related deposition of glia-associated fibrillar material in brains of c57BL/6 mice , 1994, Neuroscience.

[95]  Jiankang Liu,et al.  Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity and reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): a comparison with ddY mice , 1993, Mechanisms of Ageing and Development.

[96]  J. Kimura,et al.  Beta/A4 proteinlike immunoreactive granular structures in the brain of senescence-accelerated mouse. , 1993, The American journal of pathology.

[97]  J. Morley,et al.  Age-related changes in the pharmacological improvement of retention in senescence accelerated mouse (SAM) , 1993, Neurobiology of Aging.

[98]  J. Morley,et al.  Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM) , 1993, Neurobiology of Aging.

[99]  A. Nagaoka,et al.  Senescence-accelerated mouse (SAM): Age-related reduced anxiety-like behavior in the SAM-P/8 strain , 1992, Physiology & Behavior.

[100]  J. Morley,et al.  Age-related changes in LFA-1 expression, cell adhesion, and PHA-induced proliferation by lymphocytes from senescence-accelerated mouse (SAM)-P/8 and SAM-R/1 substrains. , 1992, Cellular immunology.

[101]  Y. Kitamura,et al.  Age-related changes in transmitter glutamate and NMDA receptor/channels in the brain of senescence-accelerated mouse , 1992, Neuroscience Letters.

[102]  J. Morley,et al.  Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse. , 1992, Journal of gerontology.

[103]  Y. Nomura,et al.  Biochemical changes related to aging in the senescence-accelerated mouse , 1989, Experimental Gerontology.

[104]  Ichiro Akiguchi,et al.  Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory , 1988, Brain Research.

[105]  H. Akiyama,et al.  [Loss of dendritic spines in hippocampal CA1 pyramidal cells in senescence accelerated mouse (SAM)--a quantitative Golgi study]. , 1987, Rinsho shinkeigaku = Clinical neurology.

[106]  Keiichi Higuchi,et al.  A new murine model of accelerated senescence , 1981, Mechanisms of Ageing and Development.