论文信息 - Evaluation of the efficacy of azithromycin and pyrimethamine, alone or in combination, for the treatment of experimental infection of mice with Toxoplasma gondii

Evaluation of the efficacy of azithromycin and pyrimethamine, alone or in combination, for the treatment of experimental infection of mice with Toxoplasma gondii

The efficacy of azithromycin and pyrimethamine in experimental infection of mice with Toxoplasma gondii was tested. Daily dosages of 200mg/kg and 12.5mg/kg, respectively, were given orally over a period of ten days. The medications were administered in combination or separately. The combined use of the drugs yielded better results, and a similar investigation using a cystogenic strain of the parasite will be conducted in a future study. Key-words: Infection by Toxoplasma gondii. Mice. Treatment. Azythromicin. Pyrimethamine. Lucia Maria Almeida Braz, Andreia Otaviani Di Pietro, Vicente Amato Neto e Francisco Oscar de Siqueira Franca Evaluation of the efficacy of azithromycin and pyrimethamine, alone or in combination, for the treatment of experimental infection of mice with Toxoplasma gondii O Toxoplasma gondii adquiriu paralelamente cada vez maior importância como patogeno oportunista, acometendo dessa maneira, numero crescente de imunodeprimidos, exemplificados por pac ientes que recebem orgaos por transplantes ou sao tratados atraves de quimioterapias diversas. Alem disso, a partir da decada de 80, passou com frequencia a determinar em in fectados pe lo v i rus da imunodeficiencia (HIV) graves disturbios cerebrais2 5 7 8. A terapeutica classica mais efetiva quanto a toxoplasmose consiste no uso da associacao da sulfadiazina e pirimetamina. No entanto, esses farmacos nao raramente causam disturbios colaterais expressivos, sobretudo de naturezas alergica ou hematologica, sendo tambem improprios para emprego durante a gravidez. Ainda mais, o sulfamidico, provoca reacoes adversas em mais de 40% dos pacientes com aids, tornando conveniente avaliar a eficacia de novos remedios2 5. E m b o r a j a e x i s t a m a l g u n s o u t r o s medicamentos com reconhecida atividade ant i toxop lasma como a c l indamic ina, o sulfametazol-trimetroprim e a espiramicina

F. França | L. Braz | V. Neto | Andréia Otaviani Di Pietro

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