Some physicochemical properties of bovine thrombin.

The physical properties of bovine prothrombin preparations have been described in this journal (1). Although methods for obtaining bovine thrombin are now also available (a), the physical properties, including the molecular weight, have not been described. Here we report values for the sedimentation coefficient, diffusion coefficient, intrinsic viscosity, frictional ratio, molecular weight, and estimated axial ratio. A revised value for the molecular weight of prothrombin is also given.