The Histone Methyltransferase G9a Controls Axon Growth by Targeting the RhoA Signaling Pathway.

[1]  Brett J. Hilton,et al.  RhoA Controls Axon Extension Independent of Specification in the Developing Brain , 2019, Current Biology.

[2]  K. Kaibuchi,et al.  Neuronal Polarity: Positive and Negative Feedback Signals , 2019, Front. Cell Dev. Biol..

[3]  Y. Shinkai,et al.  Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection. , 2019, Cell reports.

[4]  S. Sajikumar,et al.  G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons. , 2018, Cerebral cortex.

[5]  S. Sajikumar,et al.  Epigenetic regulation by G9a/GLP complex ameliorates amyloid‐beta 1‐42 induced deficits in long‐term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons , 2017, Aging cell.

[6]  K. Hahn,et al.  Discovery of long-range inhibitory signaling to ensure single axon formation , 2017, Nature Communications.

[7]  R. Zukin,et al.  The emerging field of epigenetics in neurodegeneration and neuroprotection , 2017, Nature Reviews Neuroscience.

[8]  S. Lee,et al.  ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders. , 2017, Current drug targets.

[9]  S. Sajikumar,et al.  Inhibition of G9a/GLP Complex Promotes Long-Term Potentiation and Synaptic Tagging/Capture in Hippocampal CA1 Pyramidal Neurons , 2016, Cerebral cortex.

[10]  Michiyuki Matsuda,et al.  A FRET Biosensor for ROCK Based on a Consensus Substrate Sequence Identified by KISS Technology. , 2017, Cell structure and function.

[11]  M. Itoh,et al.  Human Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Regulates Dendritic Morphogenesis , 2016, International journal of molecular sciences.

[12]  Lingli Liang,et al.  G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury , 2016, Molecular pain.

[13]  Lingli Liang,et al.  G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons , 2016, Scientific Reports.

[14]  S. Di Giovanni,et al.  A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification , 2016, The Journal of Neuroscience.

[15]  A. Emili,et al.  G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis , 2016, Stem cell reports.

[16]  G. Cho,et al.  G9a inhibition promotes neuronal differentiation of human bone marrow mesenchymal stem cells through the transcriptional induction of RE-1 containing neuronal specific genes , 2016, Neurochemistry International.

[17]  A. Cáceres,et al.  Anti-glycan antibodies halt axon regeneration in a model of Guillain Barrè Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA–ROCK-dependent inactivation of CRMP-2 , 2016, Experimental Neurology.

[18]  I. Schor,et al.  Alternative Splicing of G9a Regulates Neuronal Differentiation. , 2016, Cell reports.

[19]  C. Dotti,et al.  Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons , 2016, Nature Communications.

[20]  A. Kornblihtt,et al.  Histone methylation, alternative splicing and neuronal differentiation , 2016, Neurogenesis.

[21]  K. Kaibuchi,et al.  Radial Glial Cell–Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site , 2015, The Journal of Neuroscience.

[22]  J. Issa,et al.  G9a Is Essential for Epigenetic Silencing of K+ Channel Genes in Acute-to-Chronic Pain Transition , 2015, Nature Neuroscience.

[23]  C. Larabell,et al.  Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells , 2015, Stem cell reports.

[24]  F. Lezoualc’h,et al.  Exchange protein directly activated by cAMP (EPAC) regulates neuronal polarization through Rap1B , 2016, The FASEB Journal.

[25]  K. Kaibuchi,et al.  Extracellular and Intracellular Signaling for Neuronal Polarity. , 2015, Physiological reviews.

[26]  Felipe A. Veloso,et al.  The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a , 2015, The Journal of Neuroscience.

[27]  Cecilia Conde,et al.  A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation , 2015, Current Biology.

[28]  Xiaochun Yu,et al.  The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression , 2015, eLife.

[29]  She Chen,et al.  Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability , 2015, Genes & development.

[30]  R. Margueron,et al.  The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing. , 2014, Molecular cell.

[31]  Jacco van Rheenen,et al.  A Versatile Toolkit to Produce Sensitive FRET Biosensors to Visualize Signaling in Time and Space , 2013, Science Signaling.

[32]  Y. Hatanaka,et al.  Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone , 2011, Neuroscience Research.

[33]  Carlos G Dotti,et al.  Neuronal polarity: demarcation, growth and commitment. , 2012, Current opinion in cell biology.

[34]  Cecilia Conde,et al.  The role of small GTPases in neuronal morphogenesis and polarity , 2012, Cytoskeleton.

[35]  S. Noctor,et al.  CoREST/LSD1 control the development of pyramidal cortical neurons. , 2012, Cerebral cortex.

[36]  T. Soderling,et al.  Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca2+/Calmodulin–Dependent Protein Kinases , 2011, Science Signaling.

[37]  Zhike Lu,et al.  Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification , 2011, Cell.

[38]  F. Bradke,et al.  Neuronal polarization: The cytoskeleton leads the way , 2011, Developmental neurobiology.

[39]  C. Allis,et al.  Operating on chromatin, a colorful language where context matters. , 2011, Journal of molecular biology.

[40]  Y. Shinkai,et al.  H3K9 methyltransferase G9a and the related molecule GLP. , 2011, Genes & development.

[41]  A. Nairn,et al.  Evidence for the Involvement of Lfc and Tctex-1 in Axon Formation , 2010, The Journal of Neuroscience.

[42]  M. Poo,et al.  Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation , 2010, Science.

[43]  Ming Liu,et al.  Genome-wide identification of target genes repressed by the zinc finger transcription factor REST/NRSF in the HEK 293 cell line. , 2009, Acta biochimica et biophysica Sinica.

[44]  F. Polleux,et al.  Establishment of axon-dendrite polarity in developing neurons. , 2009, Annual review of neuroscience.

[45]  D. Schübeler,et al.  DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity , 2008, The EMBO journal.

[46]  H. Kimura,et al.  G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription , 2008, The EMBO journal.

[47]  Thomas J. Ostendorf,et al.  BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity. , 2008, Brain : a journal of neurology.

[48]  Helmut Mack,et al.  Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo , 2007, Journal of neurochemistry.

[49]  R. Heuckeroth,et al.  Protein Kinase Cζ and Glycogen Synthase Kinase-3β Control Neuronal Polarity in Developing Rodent Enteric Neurons, whereas SMAD Specific E3 Ubiquitin Protein Ligase 1 Promotes Neurite Growth But Does Not Influence Polarity , 2007, The Journal of Neuroscience.

[50]  T. Yamashita,et al.  Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. , 2007, Current pharmaceutical design.

[51]  Karl Mechtler,et al.  Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. , 2007, Molecular cell.

[52]  A. Fournier,et al.  Molecular characterization of the effects of Y-27632. , 2007, Cell motility and the cytoskeleton.

[53]  S. Kaech,et al.  Culturing hippocampal neurons , 2006, Nature Protocols.

[54]  H. Cedar,et al.  G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis , 2006, Nature Cell Biology.

[55]  C. Sung,et al.  The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. , 2005, Developmental cell.

[56]  M. Teitell,et al.  Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase , 2005, Nucleic acids research.

[57]  Berthold Göttgens,et al.  Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Arnold R Kriegstein,et al.  Patterns of neuronal migration in the embryonic cortex , 2004, Trends in Neurosciences.

[59]  A. Roopra,et al.  Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes. , 2004, Molecular cell.

[60]  K. Kaibuchi,et al.  Identification of Tau and MAP2 as novel substrates of Rho‐kinase and myosin phosphatase , 2003, Journal of neurochemistry.

[61]  H. Kato,et al.  G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. , 2002, Genes & development.

[62]  C. Dotti,et al.  Neuronal Polarity: Vectorial Cytoplasmic Flow Precedes Axon Formation , 1997, Neuron.

[63]  J. Mandell,et al.  A Spatial Gradient of Tau Protein Phosphorylation in Nascent Axons , 1996, The Journal of Neuroscience.

[64]  D. Anderson,et al.  Identification of potential target genes for the neuron-restrictive silencer factor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[65]  A. Frankfurter,et al.  The distribution of tau in the mammalian central nervous system , 1985, The Journal of cell biology.