Carbamazepine‐induced heart block in a child with tuberous sclerosis and cardiac rhabdomyoma: Implications for evaluation and follow‐up

We describe a young child with tuberous sclerosis and cardiac rhabdomyoma who developed reversible heart block after being placed on carbamazepine treatment for seizures. Patients of any age with known or suspected intrinsic cardiac disease should be monitored for conduction disturbance if they are treated with carbamazepine.

[1]  E. Kasarskis,et al.  Carbamazepine-induced cardiac dysfunction. Characterization of two distinct clinical syndromes. , 1992, Archives of internal medicine.

[2]  M. Manfredi,et al.  Carbamazepine and the heart , 1991, Annals of neurology.

[3]  A. Macnab,et al.  Heart block secondary to erythromycin-induced carbamazepine toxicity. , 1987, Pediatrics.

[4]  J. Pomerance,et al.  Spontaneous Regression of Cardiac Rhabdomyoma in Tuberous Sclerosis , 1987, Clinical pediatrics.

[5]  C. Loeb,et al.  Carbamazepine and cardiac conduction disturbances , 1987, Annals of neurology.

[6]  M. Manfredi,et al.  Sino-atrial block provoked by carbamazepine. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[7]  R. Mutani,et al.  Cardiac side effects of phenytoin and carbamazepine. A dose-related phenomenon? , 1985, Archives of neurology.

[8]  Cassidy Sb Tuberous sclerosis in children: diagnosis and course. , 1984 .

[9]  S. Ladefoged,et al.  Cardiac conduction disturbances during carbamazepine therapy , 1983, Acta neurologica Scandinavica.

[10]  V. Ferrans,et al.  Cardiac rhabdomyoma: a clinicopathologic and electron microscopic study. , 1976, The American journal of cardiology.

[11]  A. Damato,et al.  The antiarrhythmic actions of carbamazepine (Tegretol). , 1970, The Journal of pharmacology and experimental therapeutics.