Evidence of Chemoresponsiveness in Unresectable Metastatic Angiomatoid Fibrous Histiocytoma.

Angiomatoid fibrous histiocytoma (AFH) is a soft tissue neoplasm of intermediate biological potential. Typically a slow-growing tumor, it can recur locally. Rarely, it manifests as a soft tissue sarcoma capable of metastasis. When metastases are nonamenable to local therapy, it is believed uniformly fatal. We present 3 patients with metastatic AFH who demonstrated a sustained response to chemotherapy; including one who achieved complete remission with cryoablation. These cases reinforce the potential value of chemotherapy in some patients with unresectable metastatic AFH and provide the first case in the literature of cryoablation in AFH.

[1]  J. Blay,et al.  Tocilizumab for the treatment of paraneoplastic inflammatory syndrome associated with angiomatoid fibrous histiocytoma , 2020, ESMO Open.

[2]  B. Al-Lazikani,et al.  A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations , 2019, European journal of cancer.

[3]  B. Naik-Mathuria,et al.  Therapeutic response of metastatic angiomatoid fibrous histiocytoma carrying EWSR1‐CREB1 fusion to the interleukin‐6 receptor antibody tocilizumab , 2018, Pediatric blood & cancer.

[4]  B. Brennan,et al.  Angiomatoid fibrous histiocytoma: A case of local recurrence and metastases to loco‐regional lymph nodes that responded to chemotherapy , 2017, Pediatric blood & cancer.

[5]  Kenichi Saito,et al.  Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review , 2017, BMC Musculoskeletal Disorders.

[6]  C. Herzog,et al.  Characterization of Metastatic Angiomatoid Fibrous Histiocytoma , 2015, Journal of pediatric hematology/oncology.

[7]  C. Fisher,et al.  Angiomatoid fibrous histiocytoma: the current status of pathology and genetics. , 2015, Archives of pathology & laboratory medicine.

[8]  P. Roux‐Lombard,et al.  A simple Baker's cyst? Tocilizumab remits paraneoplastic signs and controls growth of IL-6-producing angiomatoid malignant fibrous histiocytoma. , 2014, Rheumatology.

[9]  J. Goldblum,et al.  Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum , 2014, Pathology.

[10]  P. Cin,et al.  SUPPLEMENT 2 SPECIAL ISSUE: BONE AND SOFT TISSUE , 2012 .

[11]  A. Folpe,et al.  Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology , 2011, Modern Pathology.

[12]  A. Mansfield,et al.  Angiomatoid fibrous histiocytoma in a 25-year-old male , 2010, Rare tumors.

[13]  T. Yamashita,et al.  Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation , 2010, Journal of Clinical Pathology.

[14]  H. Tanke,et al.  EWSR1-CREB1 and EWSR1-ATF1 Fusion Genes in Angiomatoid Fibrous Histiocytoma , 2007, Clinical Cancer Research.

[15]  U. Surti,et al.  EWSR1‐CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma , 2007, Genes, chromosomes & cancer.

[16]  C. Fletcher.  The evolving classification of soft tissue tumours: an update based on the new WHO classification , 2006, Histopathology.

[17]  I. Panagopoulos,et al.  Fusion of the FUS and ATF1 Genes in a Large, Deep-Seated Angiomatoid Fibrous Histiocytoma , 2002, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[18]  M. Miettinen,et al.  Angiomatoid "malignant" fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. , 1999, Human pathology.

[19]  N. Winick,et al.  Adjuvant chemotherapy for treatment of unresectable and metastatic angiomatoid malignant fibrous histiocytoma , 1994, Cancer.

[20]  Michael J. Costa,et al.  Angiomatoid Malignant Fibrous Histiocytoma: A Follow‐up Study of 108 Cases with Evaluation of Possible Histologic Predictors of Outcome , 1990, The American journal of surgical pathology.

[21]  G. de Rosa,et al.  Angiomatoid malignant fibrous histiocytoma: cytologic, immunohistochemical, ultrastructural, and flow cytometric study of 20 cases. , 1990, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.