Akt activation induced by an antioxidant compound during ischemia-reperfusion.

[1]  T. Kálai,et al.  2,2,5,5-Tetramethylpyrroline-Based Compounds in Prevention of Oxyradical-induced Myocardial Damage , 2002, Journal of cardiovascular pharmacology.

[2]  N. Holbrook,et al.  Cellular response to oxidative stress: Signaling for suicide and survival * , 2002, Journal of cellular physiology.

[3]  F. Gao,et al.  Ischemia-Reperfusion : The Roles of PI 3-Kinase , Akt , and Endothelial Nitric Oxide Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial , 2002 .

[4]  G. Cooper,et al.  Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway , 2002, Molecular and Cellular Biology.

[5]  D. Yellon,et al.  Myocardial Protection by Insulin at Reperfusion Requires Early Administration and Is Mediated via Akt and p70s6 Kinase Cell-Survival Signaling , 2001, Circulation research.

[6]  K. Hideg,et al.  Scavenger Effect of Experimental and Clinically Used Cardiovascular Drugs , 2001, Journal of cardiovascular pharmacology.

[7]  B. Hemmings,et al.  Ten years of protein kinase B signalling: a hard Akt to follow. , 2001, Trends in biochemical sciences.

[8]  J. Woodgett,et al.  PKB/AKT: functional insights from genetic models , 2001, Nature Reviews Molecular Cell Biology.

[9]  P. Cohen,et al.  The renaissance of GSK3 , 2001, Nature Reviews Molecular Cell Biology.

[10]  R. Hajjar,et al.  Akt Activation Preserves Cardiac Function and Prevents Injury After Transient Cardiac Ischemia In Vivo , 2001, Circulation.

[11]  Z. Berente,et al.  Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. , 2001, Molecular pharmacology.

[12]  K. Webster,et al.  Molecular mechanisms of apoptosis in the cardiac myocyte. , 2001, Current opinion in pharmacology.

[13]  K. Webster,et al.  Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1 , 2001, Circulation research.

[14]  I. Kang,et al.  Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. , 2001, Life sciences.

[15]  R. Kitsis,et al.  Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. , 2000, Journal of molecular and cellular cardiology.

[16]  N. Holbrook,et al.  Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts. , 2000, The Biochemical journal.

[17]  T. Kálai,et al.  A pyrroline derivative of mexiletine offers marked protection against ischemia/reperfusion-induced myocardial contractile dysfunction. , 2000, The Journal of pharmacology and experimental therapeutics.

[18]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .

[19]  M. Marber,et al.  Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes. , 2000, The Biochemical journal.

[20]  J. Pober,et al.  A Phosphatidylinositol 3-Kinase/Akt Pathway, Activated by Tumor Necrosis Factor or Interleukin-1, Inhibits Apoptosis but Does Not Activate NFκB in Human Endothelial Cells* , 2000, The Journal of Biological Chemistry.

[21]  Guido Kroemer,et al.  Mitochondrial control of cell death , 2000, Nature Medicine.

[22]  M. Marber,et al.  Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes. , 2000, Biochemical and biophysical research communications.

[23]  R. Jope,et al.  Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis , 2000, The Journal of Biological Chemistry.

[24]  K. Hideg,et al.  Targeted antioxidant properties of N-[(tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and its nitroxide metabolite in preventing postischemic myocardial injury. , 2000, The Journal of pharmacology and experimental therapeutics.

[25]  R. Kitsis,et al.  Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. , 2000, Circulation.

[26]  C. Depré,et al.  Metabolic aspects of programmed cell survival and cell death in the heart. , 2000, Cardiovascular research.

[27]  F. Gallyas,et al.  Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart. , 1999, Free radical biology & medicine.

[28]  D. Yellon,et al.  Reperfusion injury revisited: is there a role for growth factor signaling in limiting lethal reperfusion injury? , 1999, Trends in cardiovascular medicine.

[29]  J. Romashkova,et al.  NF-κB is a target of AKT in anti-apoptotic PDGF signalling , 1999, Nature.

[30]  J. Karliner,et al.  Altered gene expression during hypoxia and reoxygenation of the heart. , 1999, Pharmacology & therapeutics.

[31]  R. Busse,et al.  Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation , 1999, Nature.

[32]  T. Kálai,et al.  Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage. , 1998, Journal of Medicinal Chemistry.

[33]  D. Butterfield,et al.  Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone , 1997 .

[34]  D. Wink,et al.  Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide (*) , 1996, The Journal of Biological Chemistry.

[35]  K. Aston,et al.  Evaluation of activity of putative superoxide dismutase mimics. Direct analysis by stopped-flow kinetics. , 1993, The Journal of biological chemistry.

[36]  K. Hideg,et al.  New antiarrhythmic agents. 2,2,5,5-Tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamindes. , 1986, Journal of medicinal chemistry.

[37]  E. Schiffrin,et al.  Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. , 2002, American journal of hypertension.

[38]  W. Degraff,et al.  Direct evidence for in vivo nitroxide free radical production from a new antiarrhythmic drug by EPR spectroscopy. , 1997, Free radical biology & medicine.

[39]  E. Monti,et al.  Protective effect of the nitroxide tempol against the cardiotoxicity of adriamycin. , 1996, Free radical biology & medicine.

[40]  L. Packer,et al.  Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart. , 1992, Free radical research communications.