Correlation between voxel based morphometry and manual volumetry in magnetic resonance images of the human brain.

This is a comparative study between manual volumetry (MV) and voxel based morphometry (VBM) as methods of evaluating the volume of brain structures in magnetic resonance images. The volumes of the hippocampus and the amygdala of 16 panic disorder patients and 16 healthy controls measured through MV were correlated with the volumes of gray matter estimated by optimized modulated VBM. The chosen structures are composed almost exclusively of gray matter. Using a 4 mm Gaussian filter, statistically significant clusters were found bilaterally in the hippocampus and in the right amygdala in the statistical parametric map correlating with the respective manual volume. With the conventional 12 mm filter,a significant correlation was found only for the right hippocampus. Therefore, narrow filters increase the sensitivity of the correlation procedure, especially when small brain structures are analyzed. The two techniques seem to consistently measure structural volume.

[1]  Michael Knapp,et al.  A powerful strategy to account for multiple testing in the context of haplotype analysis. , 2004, American journal of human genetics.

[2]  C. Del-Ben,et al.  Decreased left temporal lobe volume of panic patients measured by magnetic resonance imaging. , 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[3]  I. Johnsrude,et al.  The problem of functional localization in the human brain , 2002, Nature Reviews Neuroscience.

[4]  S. Lawrie,et al.  Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia , 2001, Biological Psychiatry.

[5]  J Mazziotta,et al.  A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[6]  Arthur W. Toga,et al.  A Probabilistic Atlas of the Human Brain: Theory and Rationale for Its Development The International Consortium for Brain Mapping (ICBM) , 1995, NeuroImage.

[7]  Karl J. Friston,et al.  Mapping of grey matter changes in schizophrenia 1 This work was presented, in part, at the VIth International Congress on Schizophrenia Research, Colorado Springs, Colorado, USA, April 1997. 1 , 1999, Schizophrenia Research.

[8]  Richard S. J. Frackowiak,et al.  Navigation-related structural change in the hippocampi of taxi drivers. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[9]  F Andermann,et al.  Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging , 1992, Neurology.

[10]  Eve C. Johnstone,et al.  Structural Gray Matter Differences between First-Episode Schizophrenics and Normal Controls Using Voxel-Based Morphometry , 2002, NeuroImage.

[11]  P. Mazzoni,et al.  Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. , 1998, The American journal of psychiatry.

[12]  Martha Elizabeth Shenton,et al.  Voxel-Based Morphometric Analysis of Gray Matter in First Episode Schizophrenia , 2002, NeuroImage.

[13]  Neil Roberts,et al.  Voxel-Based Morphometric Comparison of Hippocampal and Extrahippocampal Abnormalities in Patients with Left and Right Hippocampal Atrophy , 2002, NeuroImage.

[14]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[15]  S. Lawrie,et al.  Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia , 2003, Schizophrenia Research.

[16]  Karl J. Friston,et al.  A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains , 2001, NeuroImage.

[17]  R. Parsey,et al.  Regional brain gray matter volume differences in patients with bipolar disorder as assessed by optimized voxel-based morphometry , 2004, Biological Psychiatry.

[18]  José Alexandre de Souza Crippa,et al.  Confiabilidade da "Entrevista Clínica Estruturada para o DSM-IV - Versão Clínica" traduzida para o português Reliability of the Structured Clinical Interview for DSM-IV - Clinical Version translated into Portuguese , 2001 .

[19]  Karl J. Friston,et al.  Automatic Differentiation of Anatomical Patterns in the Human Brain: Validation with Studies of Degenerative Dementias , 2002, NeuroImage.

[20]  Karl J. Friston,et al.  Distributional Assumptions in Voxel-Based Morphometry , 2002, NeuroImage.

[21]  Karl J. Friston,et al.  A Voxel-Based Method for the Statistical Analysis of Gray and White Matter Density Applied to Schizophrenia , 1995, NeuroImage.

[22]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .