Acute Effects of Caffeine on Arterial Stiffness in Young Healthy Subjects

Background and Objectives：Coffee is one of the most popular beverages in the world. Caffeine is one of the substances contained in coffee and it is well known to increase blood pressure and the peripheral vascular resistance, in part because it stimulates the sympathetic nervous system. Arterial stiffness is an important factor for the performance of the cardiovascular system and it is an independent prognosticator of cardiovascular disease. We investigated the acute effect of caffeine on arterial stiffness in young healthy subjects. Subjects and Methods：We enrolled 20 young healthy subjects, who were randomly divided two groups. The caffeine group (10 subjects, 4 males, mean age: 23.3±1.1 years) received 520 mL caffeinated coffee and the control group (10 subjects, 4 males, mean age: 23.1±1.3 years) received 520 mL water. The arterial stiffness was evaluated by the carotid-radial pulse wave velocity and the augmentation index as corrected by heart rate (75 bpm), and all the hemodynamic measurements were obtained at baseline, 30, 60, 120 and 180 minutes after ingestion of the coffee or water. Results：Arterial stiffness measured by carotid-radial pulse wave velocity increased progressively from 9.4±1.2 m/sec at baseline to 11.5± 1.6 m/sec (p<0.05) at 30 minutes after the coffee intake. In addition, peripheral systolic pressure increased progressively from 107.1±10.2 mmHg at baseline to 114.4±12.9 mmHg (p<0.05) at 60 minutes after the coffee intake. Such changes were not seen in control group. Conclusion：Caffeine affects increased the pulse wave velocity and systolic blood pressure. This means that coffee might have an adverse effect on arterial stiffness. (Korean Circulation J 2005;35:841-846)

[1]  J. Lekakis,et al.  Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure? , 2005, International journal of cardiology.

[2]  Seongwook Han,et al.  The Change of Arterial Stiffness According to Dialysis in Patients with End-Stage Renal Disease , 2004 .

[3]  S. Han,et al.  High Aortic Stiffness Assessed by Pulse Wave Velocity is an Independent Predictor of Coronary Artery Calcification and Stenosis in Suspected Coronary Artery Disease Patients , 2004 .

[4]  Hongyu Wang,et al.  The relationship between pulse wave velocity and pulse pressure in Chinese patients with essential hypertension. , 2003, Hypertension research : official journal of the Japanese Society of Hypertension.

[5]  C. Vlachopoulos,et al.  Caffeine increases aortic stiffness in hypertensive patients. , 2002, American journal of hypertension.

[6]  Azra Mahmud,et al.  Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform , 2001, Hypertension.

[7]  P. Ducimetiere,et al.  Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients , 2001, Hypertension.

[8]  P. Toutouzas,et al.  Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease. , 2000, European heart journal.

[9]  P. Boutouyrie,et al.  Association between local pulse pressure, mean blood pressure, and large-artery remodeling. , 1999, Circulation.

[10]  J. Blacher,et al.  Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. , 1999, Hypertension.

[11]  P. Whelton,et al.  The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials. , 1999, Hypertension.

[12]  C. Vlachopoulos,et al.  Aortic function in arterial hypertension determined by pressure-diameter relation: effects of diltiazem. , 1997, Circulation.

[13]  J. E. James.  Is habitual caffeine use a preventable cardiovascular risk factor? , 1997, The Lancet.

[14]  W. Lovallo,et al.  Acute blood pressure elevations with caffeine in men with borderline systemic hypertension. , 1996, The American journal of cardiology.

[15]  P. Whelton,et al.  Blood pressure and end-stage renal disease in men. , 1996, The New England journal of medicine.

[16]  J. E. James.  Chronic Effects of Habitual Caffeine Consumption on Laboratory and Ambulatory Blood Pressure Levels , 1994, Journal of cardiovascular risk.

[17]  P. Whelton.  Epidemiology of hypertension , 1994, The Lancet.

[18]  J. Cohn,et al.  Vascular abnormalities in non-insulin-dependent diabetes mellitus identified by arterial waveform analysis. , 1993, The American journal of medicine.

[19]  N. Kon,et al.  Does radial artery pressure accurately reflect aortic pressure? , 1992, Chest.

[20]  E. Casiglia,et al.  Haemodynamic effects of coffee and caffeine in normal volunteers: a placebo‐controlled clinical study , 1991, Journal of internal medicine.

[21]  R. Vandongen,et al.  Lifestyle- and occupation‐related changes in blood pressure over a six‐year period in a cohort of working men , 1988, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[22]  Michael F. Wilson,et al.  Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men. , 1985, The American journal of cardiology.

[23]  M. Goldberg,et al.  Caffeine and hypertension. , 1984, The American journal of medicine.

[24]  J. Izzo,et al.  Age and prior caffeine use alter the cardiovascular and adrenomedullary responses to oral caffeine. , 1983, The American journal of cardiology.

[25]  R Workman,et al.  Tolerance to the humoral and hemodynamic effects of caffeine in man. , 1981, The Journal of clinical investigation.

[26]  Young Kwon Kim,et al.  The Relation of Pulse Wave Velocity with Framingham Risk Score and SCORE Risk Score , 2005 .

[27]  D. Webb,et al.  Age, arterial stiffness and the endothelium , 1997 .

[28]  M. Safar,et al.  Aortic and large artery compliance in end-stage renal failure. , 1990, Kidney international.

[29]  W. Lovallo.  Cardiovascular effects of coffee and caffeine. , 1984, The American journal of cardiology.