A 256-element ultrasonic phased array system for the treatment of large volumes of deep seated tissue

A 256-element phased array has been designed, constructed, and tested for ablative treatment of large focal volumes of deep seated tissue. The array was constructed from a 1.1-MHz, 1-3 composite piezoelectric spherical shell with a 10-cm radius of curvature and a 12-cm diameter. The array was tested to determine its electroacoustic efficiency and inter-element coupling under high acoustic power conditions. A series of in vivo porcine experiments demonstrated the ability to produce deep seated tissue lesions in thigh muscle using the large scale phased array. The array was used to heat and coagulate tissue volumes >5 cm/sup 3/ in a single ultrasound exposure using multiple foci and temporally scanned power deposition patterns. The spatial and temporal experimental results for large, heated focal volumes correlated very well with the simulated temperature response model for homogeneous tissue. A 25-cm/sup 3/ tissue volume was coagulated in a 90-min period using overlapping large ultrasound exposures.

[1]  M. Marberger,et al.  Tissue ablation in benign prostatic hyperplasia with high intensity focused ultrasound. , 1994, The Journal of urology.

[2]  K Hynynen,et al.  The Usefulness of a Contrast Agent and Gradient–Recalled Acquisition in a Steady–State Imaging Sequence for Magnetic Resonance Imaging–Guided Noninvasive Ultrasound Surgery , 1994, Investigative radiology.

[3]  P. VanBaren,et al.  Ultrasound surgery: comparison of strategies using phased array systems , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[4]  J. Driller,et al.  A Therapeutic Ultrasound System Incorporating Real-Time Ultrasonic Scanning , 1986, IEEE 1986 Ultrasonics Symposium.

[5]  K Hynynen,et al.  A comparison of theoretical and experimental ultrasound field distributions in canine muscle tissue in vivo. , 1992, Ultrasound in medicine & biology.

[6]  M. Marberger,et al.  Effect of high-intensity focused ultrasound on human prostate cancer in vivo. , 1995, Cancer research.

[7]  K. Hynynen,et al.  A parametric study of the concentric-ring transducer design for MRI guided ultrasound surgery. , 1996, The Journal of the Acoustical Society of America.

[8]  T. Grisham,et al.  The verification testing and application of an all-composite silicone rubber distribution deadend , 1995, Proceedings of ESMO'95 - 1995 IEEE 7th International Conference on Transmission and Distribution Construction, Operation and Live-Line Maintenance.

[9]  D J Coleman,et al.  Therapeutic ultrasound for the treatment of glaucoma. , 1991, American journal of ophthalmology.

[10]  Guy Vallancien,et al.  Focused Extracorporeal Pyrotherapy: Feasibility Study in Man , 1992 .

[11]  G. ter Haar,et al.  Ablation of tissue volumes using high intensity focused ultrasound. , 1996, Ultrasound in medicine & biology.

[12]  K. Hynynen,et al.  Control of the necrosed tissue volume during noninvasive ultrasound surgery using a 16-element phased array. , 1995, Medical physics.

[13]  J P Donohue,et al.  High-intensity focused ultrasound in the treatment of prostatic tissue. , 1994, Urology.

[14]  K. Hynynen,et al.  MRI-guided noninvasive ultrasound surgery. , 1993, Medical physics.

[15]  M. Tachibana,et al.  High-intensity focused ultrasound energy for benign prostatic hyperplasia: clinical response at 6 months to treatment using Sonablate 200. , 1997, Journal of endourology.

[16]  K Hynynen,et al.  Focal spacing and near-field heating during pulsed high temperature ultrasound therapy. , 1993, Ultrasound in medicine & biology.

[17]  W. Dewey,et al.  Thermal dose determination in cancer therapy. , 1984, International journal of radiation oncology, biology, physics.

[18]  Harold F. Stewart,et al.  Ultrasonic Measurement Techniques and Equipment Output Levels , 1982 .

[19]  C. Cain,et al.  A spherical-section ultrasound phased array applicator for deep localized hyperthermia , 1991, IEEE Transactions on Biomedical Engineering.

[20]  K Hynynen,et al.  A study of various parameters of spherically curved phased arrays for noninvasive ultrasound surgery. , 1996, Physics in medicine and biology.

[21]  W J FRY,et al.  Fundamental neurological research and human neurosurgery using intense ultrasound. , 1960, IRE transactions on medical electronics.

[22]  H. H. Pennes.  Analysis of tissue and arterial blood temperatures in the resting human forearm. , 1948, Journal of applied physiology.

[23]  K. Kopecky,et al.  Liver cancer ablation with extracorporeal high-intensity focused ultrasound. , 1993, European urology.

[24]  F. Duck,et al.  Amplitude-dependent losses in ultrasound exposure measurement , 1988, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[25]  F A Jolesz,et al.  Determination of the optimal delay between sonications during focused ultrasound surgery in rabbits by using MR imaging to monitor thermal buildup in vivo. , 1999, Radiology.

[26]  K. Hynynen,et al.  Feasibility of using ultrasound phased arrays for MRI monitored noninvasive surgery , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[27]  K. Hynynen,et al.  Optimization of thermal dose using switching mode patterns of a spherically shaped square element phased array , 1996, 1996 IEEE Ultrasonics Symposium. Proceedings.

[28]  K. Hynynen.  The threshold for thermally significant cavitation in dog's thigh muscle in vivo. , 1991, Ultrasound in medicine & biology.

[29]  F. Marcus,et al.  The feasibility of using ultrasound for cardiac ablation , 1993, IEEE Transactions on Biomedical Engineering.

[30]  W J FRY,et al.  Ultrasonic lesions in the mammalian central nervous system. , 1955, Science.

[31]  K. Hynynen,et al.  The combined concentric-ring and sector-vortex phased array for MRI guided ultrasound surgery , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[32]  C.A. Cain,et al.  Multiple-focus ultrasound phased-array pattern synthesis: optimal driving-signal distributions for hyperthermia , 1989, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[33]  J. Fitzpatrick,et al.  High-intensity focused ultrasound in the treatment of benign prostatic hyperplasia. , 1997, British journal of urology.

[34]  K. Hynynen,et al.  Design and evaluation of a feedback based phased array system for ultrasound surgery , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[35]  F. Lizzi,et al.  Therapeutic ultrasound in the treatment of glaucoma. II. Clinical applications. , 1985, Ophthalmology.

[36]  J. Zemanek.  Beam Behavior within the Nearfield of a Vibrating Piston , 1971 .

[37]  In vivo verification of the acoustic model used to predict temperature elevations for MRI guided ultrasound surgery , 1998, 1998 IEEE Ultrasonics Symposium. Proceedings (Cat. No. 98CH36102).

[38]  R Souchon,et al.  High-intensity focused ultrasound experimentation on human benign prostatic hypertrophy. , 1993, European urology.

[39]  K Hynynen,et al.  Ultrasound surgery using multiple sonications--treatment time considerations. , 1996, Ultrasound in medicine & biology.

[40]  L. Frizzell,et al.  Localized tissue destruction by high-intensity focused ultrasound. , 1973, Archives of surgery.

[41]  C.A. Cain,et al.  A cylindrical-section ultrasound phased-array applicator for hyperthermia cancer therapy , 1988, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[42]  K. Hynynen.  Biophysics and Technology of Ultrasound Hyperthermia , 1990 .

[43]  J Y Chapelon,et al.  Focused liver ablation by cavitation in the rabbit: a potential new method of extracorporeal treatment. , 1994, Gut.

[44]  Charles A. Cain,et al.  Concentric-Ring and Sector-Vortex Phased-Array Applicators for Ultrasound Hyperthermia , 1986 .

[45]  G. Haar,et al.  High intensity focused ultrasound--a surgical technique for the treatment of discrete liver tumours. , 1989, Physics in medicine and biology.

[46]  J. T. Kouzmanoff,et al.  Sparse random ultrasound phased array for focal surgery , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.