We have examined the structural response of a zinc 2,6-naphthalene dicarboxylate framework solid, isostructural with MOF-105, to the inclusion during crystallization of dimethylformamide, benzene, toluene, and p-xylene. These compounds, which are made up of a stacked arrangement of four-connected layers, crystallize in the space group P21/c with [Zn2(ndc)2(DMF)2]·1.6DMF (1), a = 8.075(1) A, b = 16.891(2) A, c = 12.673(2) A, β = 92.90(1)°, [Zn2(ndc)2(DMF)2]·C6H6 (2) a = 8.340(2) A, b = 15.660(4) A, c = 13.008(4) A, β = 91.340(5)°, [Zn2(ndc)2(DMF)2]·C7H8 (3), a = 8.183(2) A, b = 16.245(3) A, c = 12.920(3) A, β = 91.976(4)°, and [Zn2(ndc)2(DMF)2]·C8H10 (4), a = 7.973(2) A, b = 16.946(3) A, c = 12.922(3) A, β = 92.798(4)°. The structure is found to include p-xylene with high selectivity from mixtures of xylene isomers. In the presence of only o- or m-xylene as an additive, the structure does not crystallize. The mobility of fully deuterated benzene and toluene within compounds 2 and 3 over the temperature ran...