Exvivo ultrasound attenuation coefficient for human cervical and uterine tissue from 5 to 10 MHz.

Attenuation estimation and imaging in the cervix has been utilized to evaluate the onset of cervical ripening during pregnancy. This feature has also been utilized for the acoustic characterization of leiomyomas and myometrial tissue. In this paper, we present direct narrowband substitution measurement values of the variation in the ultrasonic attenuation coefficient in ex vivo human uterine and cervical tissue, in the 5-10 MHz frequency range. At 5 MHz, the attenuation coefficient values are similar for the different orientations of uterine tissue with values of 4.1-4.2 dB/cm, 5.1 dB/cm for the leiomyoma, and 6.3 dB/cm for the cervix. As the frequency increases, the attenuation coefficient values increase and are also spread out, with a value of approximately 12.6 dB/cm for the uterus (both parallel and perpendicular), 16.0 for the leiomyoma, and 26.8 dB/cm for the cervix at 10 MHz. The attenuation coefficient measured increases monotonically over the frequency range measured following a power law.

[1]  Tomy Varghese,et al.  Frequency-dependent complex modulus of the uterus: preliminary results , 2006, Physics in medicine and biology.

[2]  C R Hill,et al.  Ultrasonic attenuation and propagation speed in mammalian tissues as a function of temperature. , 1979, Ultrasound in medicine & biology.

[3]  J. Ophir,et al.  Ultrasonic attenuation measurements of in vivo human muscle. , 1982, Ultrasonic imaging.

[4]  K. Bhatia,et al.  Ultrasonic characteristics of leiomyoma uteri in vitro. , 2001, Ultrasound in medicine & biology.

[5]  N. Uldbjerg,et al.  Collagen concentration and biomechanical properties of samples from the lower uterine cervix in relation to age and parity in non-pregnant women , 2010, Reproductive biology and endocrinology : RB&E.

[6]  Lynette Mackay,et al.  Cervical ripening and insufficiency: from biochemical and molecular studies to in vivo clinical examination. , 2009, European journal of obstetrics, gynecology, and reproductive biology.

[7]  F. Dunn,et al.  Comprehensive compilation of empirical ultrasonic properties of mammalian tissues. , 1978, The Journal of the Acoustical Society of America.

[8]  K. Wear.  Ultrasonic attenuation in human calcaneus from 0.2 to 1.7 MHz , 2001, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[9]  J. G. Miller,et al.  Attenuation Estimation in Reflection: Progress and Prospects , 1984, Ultrasonic imaging.

[10]  Colleen C Moran,et al.  Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term. , 2005, American journal of obstetrics and gynecology.

[11]  J Ophir,et al.  Attenuation of ultrasound in normal liver and diffuse liver disease in vivo. , 1984, Ultrasonic imaging.

[12]  R. Romero,et al.  Transvaginal sonographic cervical length for the prediction of spontaneous preterm birth in twin pregnancies: a systematic review and metaanalysis. , 2010, American journal of obstetrics and gynecology.

[13]  M. Sherar,et al.  Changes in ultrasound properties of porcine kidney tissue during heating. , 2001, Ultrasound in medicine & biology.

[14]  Compression-Dependent Viscoelastic Behavior of Human Cervix Tissue , 2010, Ultrasonic imaging.

[15]  Timothy A Bigelow,et al.  In vivo ultrasonic attenuation slope estimates for detecting cervical ripening in rats: Preliminary results. , 2008, The Journal of the Acoustical Society of America.

[16]  K. Shung,et al.  High-frequency backscatter and attenuation measurements of selected bovine tissues between 10 and 30 MHz. , 2000, Ultrasound in medicine & biology.

[17]  K. Wear,et al.  Relationships among calcaneal backscatter, attenuation, sound speed, hip bone mineral density, and age in normal adult women. , 2001, The Journal of the Acoustical Society of America.

[18]  K J Parker,et al.  Ultrasonic attenuation and absorption in liver tissue. , 1983, Ultrasound in medicine & biology.

[19]  J. Ophir,et al.  Ultrasonic Attenuation Measurements of in Vivo Human Muscle , 1982 .

[20]  W. O’Brien,et al.  Ultrasonic attenuation and velocity properties in rat liver as a function of fat concentration: a study at 100 MHz using a scanning laser acoustic microscope. , 1985, The Journal of the Acoustical Society of America.

[21]  The role of glycogen and phosphate in ultrasonic attenuation of liver. , 1988, The Journal of the Acoustical Society of America.

[22]  W. Reeves,et al.  Ultrasonic Characterization of Blood During Coagulation , 1984, Journal of clinical ultrasound : JCU.

[23]  E. Madsen,et al.  Interlaboratory Comparison of Ultrasonic Backscatter Coefficient Measurements From 2 to 9 MHz , 2005, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[24]  B. Carroll,et al.  Acoustic shadowing from uterine leiomyomas: sonographic-pathologic correlation. , 1995, Radiology.

[25]  S. Laifer-Narin,et al.  US of abnormal uterine bleeding. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.

[26]  J. Ophir,et al.  Correlations of Sound Speed with Tissue Constituents in Normal and Diffuse Liver Disease , 1987, Ultrasonic imaging.

[27]  T. Dubinsky,et al.  Ultrasonographic evaluation of the endometrium in postmenopausal vaginal bleeding. , 2003, Radiologic clinics of North America.

[28]  T. M. Burke,et al.  Ultrasonically tissue-mimicking liver including the frequency dependence of backscatter. , 1982, Medical physics.

[29]  F. Olesen,et al.  Imaging Techniques for Evaluation of the Uterine Cavity and Endometrium in Premenopausal Patients Before Minimally Invasive Surgery , 2002, Obstetrical & gynecological survey.

[30]  Yassin Labyed,et al.  Estimate of the attenuation coefficient using a clinical array transducer for the detection of cervical ripening in human pregnancy. , 2011, Ultrasonics.

[31]  Francis A. Duck,et al.  Physical properties of tissue : a comprehensive reference book , 1990 .

[32]  R. Martin,et al.  Attenuation coefficient and sound speed in human myometrium and uterine fibroid tumors. , 2001, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[33]  E. Caoili,et al.  Refractory shadowing from pelvic masses on sonography: a useful diagnostic sign for uterine leiomyomas. , 2000, AJR. American journal of roentgenology.

[34]  F.L. Thurstone,et al.  Biomedical Ultrasonics , 1970, IEEE Transactions on Industrial Electronics and Control Instrumentation.

[35]  J. G. Miller,et al.  Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements. , 1999, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[36]  William D O'Brien,et al.  Quantitative Ultrasound Assessment of the Rat Cervix , 2006, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[37]  J. G. Miller,et al.  Changes in ultrasonic attenuation indicative of early myocardial ischemic injury. , 1979, The American journal of physiology.

[38]  M. Jabareen,et al.  Assessment of the in vivo biomechanical properties of the human uterine cervix in pregnancy using the aspiration test: a feasibility study. , 2009, European journal of obstetrics, gynecology, and reproductive biology.

[39]  T. M. Burke,et al.  X-ray linear attenuation coefficients in the mammographic range for ultrasonic breast phantom materials. , 1982, Radiology.