Investigation of the relative infectivity and pathogenicity of different hepatitis C virus genotypes in hemophiliacs.

To assess the relative infectivity and pathogenicity of variants of hepatitis C virus (HCV) genotypes, the distribution of genotypes in hemophilic patients who had been treated with nonvirally inactivated factor concentrates or cryoprecipitates prepared from local blood donors was compared with those found in the respective blood donor populations. Genotype frequencies differed markedly in the four countries investigated (Scotland, Hungary, South Africa, and Thailand) but in each, the HCV genotype distributions in hemophiliacs and blood donors were similar. In addition, HCV genotypes in recipients of commercially manufactured concentrates were similar to those found in the US general population. These findings provide no evidence that HCV genotypes differ significantly from each other in replication rate, transmissibility, or infectivity.

[1]  C. Frost,et al.  Epidemiological, clinical and therapeutic associations of hepatitis C types in western European patients. , 1996, Journal of hepatology.

[2]  P. Simmonds,et al.  Interferon treatment for chronic hepatitis C infection in hemophiliacs--influence of virus load, genotype, and liver pathology on response. , 1996, Blood.

[3]  E. Holmes,et al.  Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. The International HCV Collaborative Study Group. , 1995, The Journal of general virology.

[4]  P. Simmonds,et al.  Implications of variations of "conserved" regions of hepatitis C virus genome , 1995, The Lancet.

[5]  V. Paradis,et al.  Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation. , 1995, Gastroenterology.

[6]  Kenichi Kobayashi,et al.  Interferon therapy in chronic hepatitis C virus: Evidence of different outcome with respect to different viral strains , 1995, Journal of medical virology.

[7]  J. Garson,et al.  Analysis of clinical and virological factors associated with response to alpha interferon therapy in chronic hepatitis C , 1995, Journal of medical virology.

[8]  H. Thomas,et al.  Chronic hepatitis C virus infections: predictive value of genotype and level of viraemia on disease progression and response to interferon alpha. , 1995, Gut.

[9]  Christine A. Lee,et al.  Hepatitis C genotypes in hemophilic patients treated with alpha‐interferon , 1995, Journal of medical virology.

[10]  P. Simmonds,et al.  Heterogeneity of hepatitis C virus genotypes in hemophilia: relationship with chronic liver disease. , 1995, Blood.

[11]  P. Pontisso,et al.  HCV-associated liver cancer without cirrhosis , 1995, The Lancet.

[12]  G. Davis,et al.  Application of six hepatitis C virus genotyping systems to sera from chronic hepatitis C patients in the United States. , 1995, The Journal of infectious diseases.

[13]  P. Simmonds.  Variability of hepatitis C virus , 1995, Hepatology.

[14]  R. Purcell,et al.  Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and Genotypes , 1995, Seminars in liver disease.

[15]  M. Mizokami,et al.  Serum hepatitis C virus RNA level as a predictor of subsequent response to interferon‐α therapy in Japanese patients with chronic hepatitis C , 1994, Journal of medical virology.

[16]  J. Hoofnagle,et al.  Genotypic analysis of hepatitis C virus in American patients , 1994, Hepatology.

[17]  S. Mishiro,et al.  Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[18]  P. Simmonds,et al.  Frequent reinfection and reactivation of hepatitis C virus genotypes in multitransfused hemophiliacs. , 1994, Journal of Infectious Diseases.

[19]  H. Hotta,et al.  Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand , 1994, Journal of clinical microbiology.

[20]  A. Keller,et al.  Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey , 1994, Journal of clinical microbiology.

[21]  R. Purcell,et al.  Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children , 1994, The Lancet.

[22]  S Sherlock,et al.  Hepatitis C virus genotypes: An investigation of type‐specific differences in geographic origin and disease , 1994, Hepatology.

[23]  N. Hayashi,et al.  Hepatitis C virus genotype and RNA titer in the progression of type C chronic liver disease. , 1994, Journal of hepatology.

[24]  S. Mishiro,et al.  Genetic heterogeneity of hepatitis C virus. , 1994, Intervirology.

[25]  T. Jomori,et al.  Quantitation and typing of serum hepatitis C virus RNA in patients with chronic hepatitis C treated with interferon‐β , 1993, Hepatology.

[26]  R H Purcell,et al.  At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[27]  P. Simmonds,et al.  Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3 , 1993, Journal of clinical microbiology.

[28]  R. Miller,et al.  Lack of protective immunity against reinfection with hepatitis C virus. , 1993, Science.

[29]  E. Holmes,et al.  Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants. , 1992, The Journal of general virology.

[30]  A. Prince,et al.  Immunity in hepatitis C infection. , 1992, The Journal of infectious diseases.

[31]  H. Okamoto,et al.  Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. , 1992, The Journal of general virology.

[32]  J. Garson,et al.  Hepatitis C antibody profile and viraemia prevalence in adults with severe haemophilia , 1991, British journal of haematology.

[33]  M. Houghton,et al.  Hepatitis C antibody and chronic liver disease in haemophilia , 1990, The Lancet.