16 CARO — The Common Anatomy Reference Ontology

The Common Anatomy Reference Ontology (CARO) is being developed to facilitate interoperability between existing anatomy ontologies for different species, and will provide a template for building new anatomy ontologies. CARO has a structural axis of classification based on the top-level nodes of the Foundational Model of Anatomy. CARO will complement the developmental process sub-ontology of the GO Biological Process ontology, using the latter to ensure the coherent treatment of developmental stages, and to provide a common framework for the model organism communities to classify developmental structures. Definitions for the types and relationships are being generated by a consortium of investigators from diverse backgrounds to ensure applicability to all organisms. CARO will support the coordination of cross-species ontologies at all levels of anatomical granularity by crossreferencing types within the cell type ontology (CL) and the Gene Ontology (GO) Cellular Component ontology. A complete cross-species CARO could be utilized by other ontologies for cross-product generation.

[1]  U. Mittwoch.  From egg to embryo , 1992, Nature.

[2]  Eric H Davidson,et al.  The last common bilaterian ancestor. , 2002, Development.

[3]  Cornelius Rosse,et al.  A Reference Ontology for Bioinformatics: The Foundational Model of Anatomy , 2003 .

[4]  Kurt E. Johnson,et al.  Normal Table of Xenopus Laevis , 1968, The Yale Journal of Biology and Medicine.

[5]  José L. V. Mejino,et al.  Evolution of a Foundational Model of Physiology: Symbolic Representation for Functional Bioinformatics , 2004, MedInfo.

[6]  Prof. Dr. José A. Campos-Ortega,et al.  The Embryonic Development of Drosophila melanogaster , 1997, Springer Berlin Heidelberg.

[7]  G. Technau,et al.  Stage-specific inductive signals in the Drosophila neuroectoderm control the temporal sequence of neuroblast specification. , 2001, Development.

[8]  James C. Smith,et al.  From egg to embryo (2nd edn) , 1991 .

[9]  Barry Smith,et al.  On Carcinomas and Other Pathological Entities , 2005, Comparative and functional genomics.

[10]  C. Stern,et al.  Fate mapping and cell lineage analysis of Hensen's node in the chick embryo. , 1991, Development.

[11]  H. Schultze,et al.  The panderichthyid fish Elpistostege: a close relative of tetrapods? , 1985 .

[12]  Barry Smith.  Fiat Objects , 2001 .

[13]  Peter W. H. Holland,et al.  MAJOR TRANSITIONS IN ANIMAL EVOLUTION : A DEVELOPMENTAL GENETIC PERSPECTIVE , 1998 .

[14]  José L. V. Mejino,et al.  Research Paper: Motivation and Organizational Principles for Anatomical Knowledge Representation: The Digital Anatomist Symbolic Knowledge Base , 1998, J. Am. Medical Informatics Assoc..

[15]  Barry Cox,et al.  Chordate morphology , 1975, Nature.

[16]  Christopher J. Mungall,et al.  Obol: Integrating Language and Meaning in Bio-Ontologies , 2004, Comparative and functional genomics.

[17]  C. Kimmel,et al.  Stages of embryonic development of the zebrafish , 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

[18]  Gene Ontology Consortium,et al.  The Gene Ontology (GO) project in 2006 , 2005, Nucleic Acids Res..

[19]  A. Rector,et al.  Relations in biomedical ontologies , 2005, Genome Biology.