Metabolic and clinical correlates of acute ischemic infarction

We studied cerebral metabolism, anatomy, and clinical status in 36 patients with acute cerebral ischemia. Results from FDG-PET were compared with CT to find the relationships between the metabolic, anatomic, and clinical findings. Metabolic abnormalities seen on PET frequently were more extensive than the corresponding CT findings. The pattern of metabolic abnormality was significantly related to both the type of clinical syndrome and the degree of eventual recovery. No such relationships were found for the CT results. We conclude that studies of cerebral metabolism are of value in establishing prognosis after acute cerebral ischemia. Also, knowledge of the patterns of cerebral dysmetabolism provides a powerful means for the localization of clinical function.

[1]  J. Mazziotta,et al.  Comparison of glucose metabolism, x‐ray CT, and postmortem data in a patient with multiple cerebral infarcts , 1985, Neurology.

[2]  C. D. Arnett,et al.  Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [18F]Fluorodeoxyglucose and [11C]Deoxyglucose , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  K Wienhard,et al.  Journal of Cerebral Blood Flow and Metabolism Comparative Regional Analysis of 2-fluorodeoxyglucose and Methylglucose Uptake in Brain of Four Stroke Patients. with Special Reference to the Regional Estimation of the Lumped Constant , 2022 .

[4]  A. Rosenquist,et al.  Ischemic lesions of the occipital cortex and optic radiations , 1985, Neurology.

[5]  R. L. Rogers,et al.  Progressive cerebral ischemia antedates cerebrovascular symptoms by two years , 1984, Annals of neurology.

[6]  S. Jones,et al.  Tandem Van de Graaff accelerator production of positron labeled radiopharmaceuticals for routine clinical use. , 1984, The International journal of applied radiation and isotopes.

[7]  K. Herholz,et al.  Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [18F]-2-Fluoro-2-Deoxy-D-Glucose , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  J. Baron,et al.  Journal of Cerebral Blood Flow and Metabolism Local Interrelationships of Cerebral Oxygen Consumption and Glucose Utilization in Normal Subjects and in Ischemic Stroke Patients: a Positron Tomography Study , 2022 .

[9]  A. Alavi,et al.  Contralateral cerebellar hypometabolism following cerebral insult: A positron emission tomographic study , 1984, Annals of neurology.

[10]  N. Alpert,et al.  Positron imaging in ischemic stroke disease , 1984, Annals of neurology.

[11]  Richard S. J. Frackowiak,et al.  Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts , 1983, Annals of neurology.

[12]  M. Raichle,et al.  Cerebellar blood flow and metabolism in cerebral hemisphere infarction , 1983, Annals of neurology.

[13]  T. Olsen,et al.  Blood flow and vascular reactivity in collaterally perfused brain tissue. Evidence of an ischemic penumbra in patients with acute stroke. , 1983, Stroke.

[14]  G. Venables,et al.  The Cortical Ischaemic Penumbra Associated with Occlusion of the Middle Cerebral Artery in the Cat: 1. Topography of Changes in Blood Flow, Potassium Ion Activity, and EEG , 1983, Journal of Cerebral Blood Flow and Metabolism.

[15]  T Jones,et al.  Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction. , 1983, Brain : a journal of neurology.

[16]  A. Alavi,et al.  Measurement of Local Cerebral Glucose Metabolism: Application to the Study of Stroke , 1983 .

[17]  Richard S. J. Frackowiak,et al.  Cerebral Oxygen Metabolism and Blood Flow in Human Cerebral Ischemic Infarction , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  O. Houser,et al.  Radiologic evaluation of ischemic cerebrovascular syndromes with emphasis on computed tomography. , 1982, Radiologic clinics of North America.

[19]  R. Bajcsy,et al.  Technical note. Computer assisted analysis of tomographic images of the brain. , 1981, Journal of computer assisted tomography.

[20]  T Jones,et al.  Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. , 1981, Brain : a journal of neurology.

[21]  B. Siesjö,et al.  Thresholds in cerebral ischemia - the ischemic penumbra. , 1981, Stroke.

[22]  M E Phelps,et al.  18FDG positron emission computed tomography in a study of aphasia , 1981, Annals of neurology.

[23]  B. Siesjö.  Cell Damage in the Brain: A Speculative Synthesis , 1981, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[24]  David E. Kuhl,et al.  Effect of Ischemia on Quantification of Local Cerebral Glucose Metabolic Rate in Man , 1981, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[25]  M E Phelps,et al.  EFFECTS OF STROKE ON LOCAL CEREBRAL METABOLISM AND PERFUSION: MAPPING BY EMISSION COMPUTED TOMOGRAPHY OF 18FDG AND 13NH3 , 1980, Annals of neurology.

[26]  A. Alavi,et al.  The [18F]Fluorodeoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization in Mane , 1979, Circulation research.

[27]  M. Reivich,et al.  Use of the 2-deoxyglucose method of local cerebral glucose utilization in the abnormal brain: Evaluation of the lumped constant during ischemia , 1979 .

[28]  C. S. Higgins,et al.  Design considerations for a positron emission transverse tomograph (PETT V) for imaging of the brain. , 1978, Journal of computer assisted tomography.

[29]  M. Reivich,et al.  THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1 , 1977, Journal of neurochemistry.