Low Prevalence of Antibodies against Human Immunodeficiency Virus in Finnish Haemophiliacs

Abstract. National yearly surveys were carried out between 1985 and 1989 to determine the prevalence of antibodies for human immunodeficiency virus (HIV) in Finnish patients with bleeding disorders. From 192 out of the 214 haemophiliacs (90%) tested, 2 patients were positive for anti‐HIV. No seropositivities were found after 1985. Fourteen out of 21 patients (67%) with type III von Willebrand's disease, and 7 out of 8 patients (88%) with factor XIII deficiency were tested with negative results. The low prevalence of anti‐HIV (0.94%; 2/213 tested), is mainly due to the self‐sufficiency for clotting factors, the low prevalence of HIV in the population, and the use of cryoprecipitate during the critical period.

[1]  V. Rasi,et al.  Antibodies to Hepatitis C Virus and Chronic Liver Disease among Finnish Patients with Haemophilia , 1990 .

[2]  C. Forbes,et al.  4 HIV-1 infection in haemophilia , 1990 .

[3]  C. Forbes,et al.  HIV-1 infection in haemophilia. , 1990, Bailliere's clinical haematology.

[4]  M. Ragni.  AIDS and treatment of hemophilia patients , 1988 .

[5]  H. Rollag,et al.  HIV infection in Norwegian haemophiliacs: The prevalence of antibodies against HIV in haemophiliacs treated with lyophilized cryoprecipitate from volunteer donors , 1987, European journal of haematology.

[6]  B. Hansson,et al.  HIV seroconversion in Swedish haemophiliacs: Relation to type and dosage of factor concentrate , 1987, European journal of haematology.

[7]  S. Lopaciuk,et al.  HIV Antibody Status and Immunological Abnormalities in Polish Haemophiliacs , 1987, Thrombosis and Haemostasis.

[8]  M. Blombäck,et al.  HIV infection in a defined population of Swedish haemophiliacs. , 1987, Scandinavian journal of infectious diseases.

[9]  E. Scheibel,et al.  Antibodies against HTLV-III in Danish haemophiliacs: relation to source of factor VIII used in treatment and immunological parameters. , 2009, Scandinavian journal of haematology.

[10]  R. Gallo,et al.  Methods in laboratory investigation. Application of the indirect enzyme-linked immunosorbent assay microtest to the detection and surveillance of human t cell leukemia-lymphoma virus. , 1983, Laboratory investigation; a journal of technical methods and pathology.