Gastric and duodenal polyps in familial polyposis coli.

Endoscopy with multiple biopsies of the upper gastrointestinal tract was repeated yearly over a two to six year period in nine patients with familial polyposis coli from three families. Adenomatous polyps, one to 20 in number and 2-8 mm in size, were detected in the antrum and the first and second duodenal portions in seven patients, while hyperplastic polyps were detected in four patients in the gastric body. In two patients adenomatous tubules were observed in the biopsies of endoscopically normal mucosa from the same area where adenomatous polyps later developed. Lymphoid polyps were detected in the antrum in three cases. Double contrast radiology correlated poorly with endoscopy in the gastric body; it allowed detection of polyps in the third duodenal portion in two more patients. These results confirm that the incidence of adenomas in the upper gastrointestinal tract in familial polyposis coli may be higher than previously suspected.

[1]  M. Enjoji,et al.  Gastric lesions in familial adenomatosis coli: their incidence and histologic analysis. , 1978, Human pathology.

[2]  M. Ida,et al.  Duodenal lesions in familial polyposis of the colon. , 1977, Gastroenterology.

[3]  I. Laufer.  A simple method for routine double-contrast study of the upper gastrointestinal tract. , 1975, Radiology.

[4]  H. Bussey,et al.  Familial polyposis coli. , 1975, Pathology annual.

[5]  L. N. Shull,et al.  Lymphoid Polyposis Associated with Familial Polyposis and Gardner's Syndrome , 1974, Annals of surgery.

[6]  T. Iwama,et al.  Gastric lesion of familial polyposis coli , 1974, Cancer.

[7]  O. Beahrs,et al.  Adenocarcinoma of the duodenum and the Gardner syndrome. , 1973, JAMA.

[8]  R. Melmed,et al.  Duodenal involvement in Gardner's syndrome , 1972, Gut.

[9]  D. Hoffmann,et al.  Polyposis of the stomach and small intestine in association with familial polyposis coli , 1971, The British journal of surgery.

[10]  T. G. Parks,et al.  Familial polyposis coli associated with extracolonic abnormalities , 1970, Gut.

[11]  R. Byron,et al.  Familial polyposis of the entire gastrointestinal tract. , 1969, Archives of surgery.

[12]  S. Boley,et al.  The management of familial gastrointestinal polyposis involving stomach and colon. , 1961, Surgery.

[13]  R. Harned,et al.  Gastric polyps in familial polyposis coli. , 1979, Radiology.

[14]  T. Muto,et al.  Radiographic features of gastric polyps in familial adenomatosis coli. , 1977, AJR. American journal of roentgenology.

[15]  L. O. Tim,et al.  Benign lymphoid hyperplasia of the gastric antrum - another cause of "etat mammelonne". , 1977, The British journal of radiology.