A comprehensive genetic map of the mouse genome

THE availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons1,2. We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse3–6. Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.

[1]  Eric S. Lander,et al.  A genetic map of the mouse with 4,006 simple sequence length polymorphisms , 1994, Nature Genetics.

[2]  M. Lyon,et al.  Genetic variants and strains of the laboratory mouse , 1989 .

[3]  Cécile Fizames,et al.  A comprehensive genetic map of the human genome based on 5,264 microsatellites , 1996, Nature.

[4]  N. Copeland,et al.  Development and applications of a molecular genetic linkage map of the mouse genome. , 1991, Trends in genetics : TIG.

[5]  E S Lander,et al.  Systematic detection of errors in genetic linkage data. , 1992, Genomics.

[6]  E. Lander,et al.  A genetic linkage map of the mouse: current applications and future prospects. , 1993, Science.

[7]  L Kruglyak,et al.  An STS-Based Map of the Human Genome , 1995, Science.

[8]  N. Copeland,et al.  A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. , 1989, Genetics.

[9]  D. Simon,et al.  Towards high resolution maps of the mouse and human genomes--a facility for ordering markers to 0.1 cM resolution. European Backcross Collaborative Group. , 1994, Human molecular genetics.

[10]  A. Monaco,et al.  Yeast artificial chromosome libraries containing large inserts from mouse and human DNA. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[11]  N. G. Copeland,et al.  Genome maps IV 1993. Wall chart. , 1993, Science.

[12]  M. Daly,et al.  A genetic linkage map of the laboratory rat, Rattus norvegicus , 1995, Nature Genetics.

[13]  E S Lander,et al.  A genetic map of the mouse suitable for typing intraspecific crosses. , 1992, Genetics.

[14]  N. Copeland,et al.  A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes. , 1989, Genomics.

[15]  M. Daly,et al.  MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. , 1987, Genomics.