Animal models of dementia and cognitive dysfunction.

[1]  Yan-min Wang,et al.  7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction. , 2014, Rejuvenation research.

[2]  Ling Li,et al.  Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis , 2014, Journal of neurochemistry.

[3]  Yuchan Wang,et al.  Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice , 2014, Pharmacology Biochemistry and Behavior.

[4]  A. Bilkei-Gorzo,et al.  Genetic mouse models of brain ageing and Alzheimer's disease. , 2014, Pharmacology & therapeutics.

[5]  Hua-rong Yu,et al.  Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats , 2014, Neurological Sciences.

[6]  S. Yamada,et al.  Neuroprotective effect of nobiletin on cerebral ischemia–reperfusion injury in transient middle cerebral artery-occluded rats , 2014, Brain Research.

[7]  D. Chen,et al.  β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice , 2014, Brain Research.

[8]  A. Hazell,et al.  Pyrithiamine-induced thiamine deficiency alters proliferation and neurogenesis in both neurogenic and vulnerable areas of the rat brain , 2014, Metabolic Brain Disease.

[9]  A. Takashima,et al.  Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice , 2014, Acta Neuropathologica.

[10]  C. DeCarli,et al.  Associations between serum cholesterol levels and cerebral amyloidosis. , 2014, JAMA neurology.

[11]  S. Hoyer,et al.  Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin , 2014, Neuropharmacology.

[12]  Koretarō Takahashi,et al.  The protective effect of eicosapentaenoic acid-enriched phospholipids from sea cucumber Cucumaria frondosa on oxidative stress in PC12 cells and SAMP8 mice , 2014, Neurochemistry International.

[13]  Nirmal Singh,et al.  Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice , 2014, The International journal of neuroscience.

[14]  P. Pesini,et al.  Neprilysin Is Poorly Expressed in the Prefrontal Cortex of Aged Dogs with Cognitive Dysfunction Syndrome , 2014, International journal of Alzheimer's disease.

[15]  Guangan Zhou,et al.  Protective Effects of p38 MAPK Inhibitor SB202190 against Hippocampal Apoptosis and Spatial Learning and Memory Deficits in a Rat Model of Vascular Dementia , 2013, BioMed research international.

[16]  T. Hartmann,et al.  Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease , 2013, Front. Aging Neurosci..

[17]  H. Joshi,et al.  Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice. , 2013, Pakistan journal of biological sciences : PJBS.

[18]  J. Xing,et al.  Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. , 2013, VASA. Zeitschrift fur Gefasskrankheiten.

[19]  N. Arnal,et al.  Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration , 2013, International journal of Alzheimer's disease.

[20]  T. Ishihara,et al.  Accelerated Tau Aggregation, Apoptosis and Neurological Dysfunction Caused by Chronic Oral Administration of Aluminum in a Mouse Model of Tauopathies , 2013, Brain pathology.

[21]  X. M. Zhang,et al.  Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42. , 2013, Die Pharmazie.

[22]  A. Cuello,et al.  Modeling Alzheimer’s disease in transgenic rats , 2013, Molecular Neurodegeneration.

[23]  Sukhvir Kaur,et al.  Zinc Deficiency and Zinc Therapy Efficacy with Reduction of Serum Free Copper in Alzheimer's Disease , 2013, International journal of Alzheimer's disease.

[24]  M. Mansouri,et al.  Gallic acid prevents memory deficits and oxidative stress induced by intracerebroventricular injection of streptozotocin in rats , 2013, Pharmacology Biochemistry and Behavior.

[25]  Fabienne Aujard,et al.  Animal models of Alzheimer's disease and drug development. , 2013, Drug discovery today. Technologies.

[26]  Annette Schenck,et al.  Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner , 2013, Nature Neuroscience.

[27]  Derick H. Lindquist,et al.  Neonatal ethanol exposure results in dose-dependent impairments in the acquisition and timing of the conditioned eyeblink response and altered cerebellar interpositus nucleus and hippocampal CA1 unit activity in adult rats. , 2013, Alcohol.

[28]  Wei Zhang,et al.  Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats. , 2013, Neurotoxicology.

[29]  J. Cirrito,et al.  Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD , 2013, Molecular Neurodegeneration.

[30]  W. Lukiw,et al.  Selective accumulation of aluminum in cerebral arteries in Alzheimer's disease (AD). , 2013, Journal of inorganic biochemistry.

[31]  F. Jessen,et al.  Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism , 2013, Proceedings of the National Academy of Sciences.

[32]  Nirmal Singh,et al.  Defensive Effect of Lansoprazole in Dementia of AD Type in Mice Exposed to Streptozotocin and Cholesterol Enriched Diet , 2013, PloS one.

[33]  Rimma Lapovok,et al.  Mechanical Strength and Biocompatibility of Ultrafine-Grained Commercial Purity Titanium , 2013, BioMed research international.

[34]  Hong Jiang,et al.  Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice , 2013, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[35]  S. Rai,et al.  Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology. , 2013, Neurotoxicology.

[36]  Yan Liu,et al.  Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats. , 2013, European journal of pharmacology.

[37]  S. Babri,et al.  Effects of different exercise protocols on ethanol-induced spatial memory impairment in adult male rats. , 2013, Alcohol.

[38]  Y. Kee,et al.  Tackling neurodegenerative diseases: animal models of Alzheimer’s disease and Parkinson’s disease , 2013, Genes & Genomics.

[39]  J. Ávila,et al.  Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration , 2013, Marine drugs.

[40]  Ru-yi Zhang,et al.  [Effects of Shenwu capsule on learning-memory ability and cholinergic function of brain in AD-like rat model induced by chronic infusion of sodium azide by minipump]. , 2013, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[41]  Ming Yan,et al.  [Study on protective effect of acteoside on cellular model of Alzheimer's disease induced by okadaic acid]. , 2013, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[42]  Shaohui Zong,et al.  Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats. , 2013, Rejuvenation research.

[43]  Jean-Michel Verdier,et al.  Increased Amyloid-β Peptide-Induced Memory Deficits in Phospholipid Transfer Protein (PLTP) Gene Knockout Mice , 2013, Neuropsychopharmacology.

[44]  F. Islam,et al.  Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type , 2013, Neurochemistry International.

[45]  Zhan-jun Zhang,et al.  Ameliorative Effects of a Combination of Baicalin, Jasminoidin and Cholic Acid on Ibotenic Acid-Induced Dementia Model in Rats , 2013, PloS one.

[46]  Véronique D. Bohbot,et al.  Spatial navigational strategies correlate with gray matter in the hippocampus of healthy older adults tested in a virtual maze , 2013, Front. Ag. Neurosci..

[47]  H. Alaei,et al.  The Effect of Treadmill Running on Passive Avoidance Learning in Animal Model of Alzheimer Disease , 2013, International journal of preventive medicine.

[48]  Xia Jiang,et al.  Betaine attenuates Alzheimer‐like pathological changes and memory deficits induced by homocysteine , 2013, Journal of neurochemistry.

[49]  T. Ishrat,et al.  Naringenin ameliorates Alzheimer’s disease (AD)-type neurodegeneration with cognitive impairment (AD-TNDCI) caused by the intracerebroventricular-streptozotocin in rat model , 2012, Neurochemistry International.

[50]  Frank M LaFerla,et al.  Animal models of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[51]  E. Weeber,et al.  APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease* , 2012, The Journal of Biological Chemistry.

[52]  Nirmal Singh,et al.  Salutary effect of NFκB inhibitor and folacin in hyperhomocysteinemia–hyperlipidemia induced vascular dementia , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[53]  R. Sandhir,et al.  Neuroprotective Effects of Bacopa monnieri in Experimental Model of Dementia , 2012, Neurochemical Research.

[54]  L. S. Resende,et al.  Translational Rodent Models of Korsakoff Syndrome Reveal the Critical Neuroanatomical Substrates of Memory Dysfunction and Recovery , 2012, Neuropsychology Review.

[55]  F. Tarazi,et al.  Pharmacotherapies for Alzheimer's disease: beyond cholinesterase inhibitors. , 2012, Pharmacology & therapeutics.

[56]  P. Goverdhan,et al.  Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress , 2012, International journal of Alzheimer's disease.

[57]  K. Ramasamy,et al.  Protective effects of total alkaloidal extract from Murraya koenigii leaves on experimentally induced dementia. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[58]  I. Tooyama,et al.  Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Cognitive Function of Kainic Acid-Induced Learning and Memory Deficit Animals , 2012, Cell transplantation.

[59]  Xiaorui Cheng,et al.  JD-30, an active fraction extracted from Danggui–Shaoyao–San, decreases β-amyloid content and deposition, improves LTP reduction and prevents spatial cognition impairment in SAMP8 mice , 2012, Experimental Gerontology.

[60]  B. Oken,et al.  Stress-Related Cognitive Dysfunction in Dementia Caregivers , 2011, Journal of geriatric psychiatry and neurology.

[61]  K. Q. Lu'o'ng,et al.  Role of Thiamine in Alzheimer's Disease , 2011, American journal of Alzheimer's disease and other dementias.

[62]  R. Vetreno,et al.  Alcohol-related amnesia and dementia: Animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment , 2011, Neurobiology of Learning and Memory.

[63]  S. Pan,et al.  Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity. , 2011, Basic & clinical pharmacology & toxicology.

[64]  P. Reddy,et al.  Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease , 2011, Brain Research.

[65]  A. Jaggi,et al.  Pharmacological investigations on potential of peroxisome proliferator-activated receptor-gamma agonists in hyperhomocysteinemia-induced vascular dementia in rats , 2011, Neuroscience.

[66]  M. Ruegg,et al.  Neuropathology in Mice Expressing Mouse Alpha-Synuclein , 2011, PloS one.

[67]  R. Thandavarayan,et al.  Ocimum sanctum Linn. leaf extracts inhibit acetylcholinesterase and improve cognition in rats with experimentally induced dementia. , 2011, Journal of medicinal food.

[68]  Olaf Riess,et al.  Behavioral and In Vivo Electrophysiological Evidence for Presymptomatic Alteration of Prefrontostriatal Processing in the Transgenic Rat Model for Huntington Disease , 2011, The Journal of Neuroscience.

[69]  Nitin Bansal,et al.  Antiamnesic Activity of an Ayurvedic Formulation Chyawanprash in Mice , 2011, Evidence-based complementary and alternative medicine : eCAM.

[70]  Gianluigi Forloni,et al.  APP Transgenic Mice: Their Use and Limitations , 2011, NeuroMolecular Medicine.

[71]  Nirmal Singh,et al.  Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer’s disease , 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

[72]  M. Valko,et al.  Advances in metal-induced oxidative stress and human disease. , 2011, Toxicology.

[73]  P. Tsvetkov,et al.  Zinc-induced dimerization of the amyloid-β metal-binding domain 1-16 is mediated by residues 11-14. , 2011, Molecular bioSystems.

[74]  R. Goyal,et al.  Investigation of Neuropsychopharmacological Effects of a Polyherbal Formulation on the Learning and Memory Process in Rats , 2011, Journal of young pharmacists : JYP.

[75]  G. Perry,et al.  Role of metal dyshomeostasis in Alzheimer's disease. , 2011, Metallomics : integrated biometal science.

[76]  M. Coletta,et al.  Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease. , 2011, Chemistry.

[77]  G. Drewes,et al.  The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner , 2011, The Journal of cell biology.

[78]  Mary Savage,et al.  Induction of Alzheimer’s‐like changes in brain of mice expressing mutant APP fed excess methionine , 2011, Journal of neurochemistry.

[79]  J. Simpkins,et al.  An okadaic acid-induced model of tauopathy and cognitive deficiency , 2010, Brain Research.

[80]  E. Sigurdsson,et al.  Murine models of Alzheimer's disease and their use in developing immunotherapies. , 2010, Biochimica et biophysica acta.

[81]  Nirmal Singh,et al.  Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions , 2010, Pharmacological reports : PR.

[82]  Nirmal Singh,et al.  Pitavastatin and 4'-hydroxy-3'-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes. , 2010, Current neurovascular research.

[83]  S. Skaper,et al.  Transgenic mouse models of Parkinson's disease and Huntington's disease. , 2010, CNS & neurological disorders drug targets.

[84]  Anil Kumar,et al.  Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. , 2010, Journal of medicinal food.

[85]  Angèle T Parent,et al.  Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function , 2010, International journal of Alzheimer's disease.

[86]  M. Zarrindast,et al.  Inhibition of dorsal hippocampal nitric oxide synthesis potentiates ethanol-induced state-dependent memory in mice , 2010, Behavioural Brain Research.

[87]  W. Le,et al.  Pathological role of hypoxia in Alzheimer's disease , 2010, Experimental Neurology.

[88]  Nirmal Singh,et al.  Modulation of neuroprotective effect of ischemic post-conditioning by dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in mice. , 2010, Biological & pharmaceutical bulletin.

[89]  E. Cherubini,et al.  In the Adult Hippocampus, Chronic Nerve Growth Factor Deprivation Shifts GABAergic Signaling from the Hyperpolarizing to the Depolarizing Direction , 2010, The Journal of Neuroscience.

[90]  G. Saxena,et al.  Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity , 2010, Brain Research.

[91]  B. Platt,et al.  Scopolamine-induced deficits in social memory in mice: Reversal by donepezil , 2009, Behavioural Brain Research.

[92]  M. Beal,et al.  Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model , 2009, Neurobiology of Aging.

[93]  Anil Kumar,et al.  Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress , 2009, International journal of Alzheimer's disease.

[94]  P. Davies,et al.  Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology , 2009, The Journal of Neuroscience.

[95]  D. Holtzman,et al.  The Role of Apolipoprotein E in Alzheimer's Disease , 2009, Neuron.

[96]  T. Ikejima,et al.  Silibinin prevents amyloid β peptide‐induced memory impairment and oxidative stress in mice , 2009, British journal of pharmacology.

[97]  D. Flood,et al.  A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition , 2009, Neurobiology of Aging.

[98]  R. Mahley,et al.  Alzheimer disease: Multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches , 2009, Annals of neurology.

[99]  F. Liu,et al.  Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice , 2009, The Journal of Neuroscience.

[100]  Nirmal Singh,et al.  Beneficial Effects of Donepezil on Vascular Endothelial Dysfunction-Associated Dementia Induced by L-Methionine in Rats , 2009 .

[101]  Anil Kumar,et al.  Neuroprotective effect of carvedilol, an adrenergic antagonist against colchicine induced cognitive impairment and oxidative damage in rat , 2009, Pharmacology Biochemistry and Behavior.

[102]  D. Mikhailidis,et al.  Evaluation of the effect of oxidative stress and vitamin E supplementation on renal function in rats with streptozotocin-induced Type 1 diabetes. , 2009, Journal of diabetes and its complications.

[103]  D. Wolfer,et al.  Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis , 2009, Neurochemical Research.

[104]  C. Cao,et al.  The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-review , 2008, BMC Neuroscience.

[105]  D. Guha,et al.  Alteration of brain monoamines & EEG wave pattern in rat model of Alzheimer's disease & protection by Moringa oleifera. , 2008, The Indian journal of medical research.

[106]  N. Singewald,et al.  Chronic treatment with a selective neurokinin-1 receptor antagonist in a mouse model of trait anxiety and depression: focus on behaviour and neuropeptidergic mechanisms , 2008, BMC Pharmacology.

[107]  F. Yan,et al.  Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia , 2008, Acta Neuropathologica.

[108]  L. Cormack,et al.  Alcohol-induced retrograde memory impairment in rats: prevention by caffeine , 2008, Psychopharmacology.

[109]  Nirmal Singh,et al.  Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats , 2008, BMC pharmacology.

[110]  S. Hoyer,et al.  Long-term effects of corticosterone on behavior, oxidative and energy metabolism of parietotemporal cerebral cortex and hippocampus of rats: comparison to intracerebroventricular streptozotocin , 2008, Journal of Neural Transmission.

[111]  P. Ramarao,et al.  Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats. , 2008, European journal of pharmacology.

[112]  M. Glicksman,et al.  Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. , 2008, Biochemistry.

[113]  J. Götz,et al.  Animal models of Alzheimer's disease and frontotemporal dementia , 2008, Nature Reviews Neuroscience.

[114]  P. Kidd,et al.  Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. , 2008, Alternative medicine review : a journal of clinical therapeutic.

[115]  M. Zarrindast,et al.  Ethanol state-dependent memory: Involvement of dorsal hippocampal muscarinic and nicotinic receptors , 2008, Neurobiology of Learning and Memory.

[116]  J. Stokholm,et al.  Alzheimer disease‐like clinical phenotype in a family with FTDP‐17 caused by a MAPT R406W mutation , 2008, European journal of neurology.

[117]  Yanling Zhao,et al.  Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage , 2008, Neurobiology of Disease.

[118]  D. Holtzman,et al.  Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. , 2008, The Journal of clinical investigation.

[119]  K. Langa,et al.  Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study , 2007, Neuroepidemiology.

[120]  W. Spooren,et al.  Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice , 2007, Neurobiology of Aging.

[121]  M. Weinstock,et al.  Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: Prevention by ladostigil , 2007, Experimental Neurology.

[122]  Nilüfer Ertekin-Taner,et al.  Genetics of Alzheimer's disease: a centennial review. , 2007, Neurologic clinics.

[123]  N. Tajima,et al.  The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. , 2007, European journal of pharmacology.

[124]  Nirmal Singh,et al.  Reversal of memory deficits by Atorvastatin and Simvastatin in rats. , 2007, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[125]  Xiongwei Zhu,et al.  Vascular oxidative stress in Alzheimer disease , 2007, Journal of the Neurological Sciences.

[126]  B. Platt,et al.  Dissociation of cholinergic function in spatial and procedural learning in rats , 2007, Neuroscience.

[127]  H. Soininen,et al.  Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish population , 2007, Journal of Medical Genetics.

[128]  Anil Kumar,et al.  Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. , 2007, Pharmacological reports : PR.

[129]  P. Riederer,et al.  Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein , 2007, Journal of neurochemistry.

[130]  U. Hoffmann,et al.  Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction. , 2007, Archives of medical research.

[131]  D. Quartermain,et al.  Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease , 2006, Proceedings of the National Academy of Sciences.

[132]  Anil Kumar,et al.  Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. , 2006, European journal of pharmacology.

[133]  Peter Paul De Deyn,et al.  Model organisms: Drug discovery in dementia: the role of rodent models , 2006, Nature Reviews Drug Discovery.

[134]  Andy Husband,et al.  Different types of dementia , 2006, Pharmaceutical Journal.

[135]  M. Schrag,et al.  Deposition of iron and β‐amyloid plaques is associated with cortical cellular damage in rabbits fed with long‐term cholesterol‐enriched diets , 2006, Journal of neurochemistry.

[136]  R. Obeid,et al.  Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia , 2006, FEBS letters.

[137]  I. Grundke‐Iqbal,et al.  Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target , 2006, Journal of biomedicine & biotechnology.

[138]  S. Tayebati Animal models of cognitive dysfunction , 2006, Mechanisms of Ageing and Development.

[139]  H. Joshi,et al.  Evaluation of nootropic potential of Ocimum sanctum Linn. in mice. , 2006, Indian journal of experimental biology.

[140]  J. Micó,et al.  Influence of chronic treatment with olanzapine, clozapine and scopolamine on performance of a learned 8-arm radial maze task in rats , 2006, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[141]  M. Staufenbiel,et al.  Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice* , 2005, Journal of Biological Chemistry.

[142]  Bin Zhang,et al.  Axonal Degeneration Induced by Targeted Expression of Mutant Human Tau in Oligodendrocytes of Transgenic Mice That Model Glial Tauopathies , 2005, The Journal of Neuroscience.

[143]  Fei Liu,et al.  Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation , 2005, The European journal of neuroscience.

[144]  D. Butterfield,et al.  The senescence-accelerated prone mouse (SAMP8): A model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease , 2005, Experimental Gerontology.

[145]  D. Holtzman,et al.  The Bad Seed in Alzheimer’s Disease , 2005, Neuron.

[146]  B. Hyman,et al.  Transgenic models of Alzheimer’s disease: Learning from animals , 2005, NeuroRX.

[147]  C. Cotman,et al.  β-Amyloid deposition and tau phosphorylation in clinically characterized aged cats , 2005, Neurobiology of Aging.

[148]  Nobutaka Hirokawa,et al.  Molecular motors and mechanisms of directional transport in neurons , 2005, Nature Reviews Neuroscience.

[149]  E. Masliah,et al.  Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease , 2005, Science.

[150]  R. Pluta From brain ischemia-reperfusion injury to possible sporadic Alzheimer's disease. , 2004, Current neurovascular research.

[151]  A. Devlin,et al.  Cerebral Vascular Dysfunction in Methionine Synthase–Deficient Mice , 2004, Circulation.

[152]  T. V. Van Dooren,et al.  β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE × APP[V717I] Double-Transgenic Mice , 2004 .

[153]  D. Westaway,et al.  Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. , 2004, Journal of psychiatry & neuroscience : JPN.

[154]  R. Urbanics,et al.  A chronic Alzheimer’s model evoked by mitochondrial poison sodium azide for pharmacological investigations , 2004, Behavioural Brain Research.

[155]  A. Wyse,et al.  Chronic hyperhomocysteinemia provokes a memory deficit in rats in the Morris water maze task , 2004, Behavioural Brain Research.

[156]  G. Lenzi,et al.  Delayed poststroke dementia , 2004, Neurology.

[157]  Giovanni Scapagnini,et al.  Free radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[158]  D. Butterfield,et al.  Free radicals and brain aging. , 2004, Clinics in geriatric medicine.

[159]  H. Steinbusch,et al.  Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. , 2004, The American journal of pathology.

[160]  S. Kulkarni,et al.  Memory enhancing activity of Glycyrrhiza glabra in mice. , 2004, Journal of ethnopharmacology.

[161]  P. Riederer,et al.  Gene expression profile in streptozotocin rat model for sporadic Alzheimer’s disease , 2004, Journal of Neural Transmission.

[162]  M. Mattson,et al.  Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction , 2003, Neuron.

[163]  Nirmal Singh,et al.  Sildenafil improves acquisition and retention of memory in mice. , 2003, Indian journal of physiology and pharmacology.

[164]  K. Kishore,et al.  Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia , 2003, Behavioural Brain Research.

[165]  Matthew P. Frosch,et al.  Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[166]  U. Igbavboa,et al.  Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease. , 2003, Biochimica et biophysica acta.

[167]  Lieve Dillen,et al.  Characterization of amyloid β peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein , 2003 .

[168]  C. Geula,et al.  Distribution, progression and chemical composition of cortical amyloid-β deposits in aged rhesus monkeys: similarities to the human , 2003, Acta Neuropathologica.

[169]  C. Barnes,et al.  The neurobiology of memory changes in normal aging , 2003, Experimental Gerontology.

[170]  M. Kumar,et al.  Intracerebroventricular administration of colchicine produces cognitive impairment associated with oxidative stress in rats , 2002, Pharmacology Biochemistry and Behavior.

[171]  P. Zuo,et al.  Cholinergic receptor activity after quinolinic acid caused cerebral injury in rats. , 2002, Chinese medical journal.

[172]  F. Gomez-Pinilla,et al.  A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning , 2002, Neuroscience.

[173]  A. Cattaneo,et al.  Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti‐nerve‐growth‐factor mice , 2002, The European journal of neuroscience.

[174]  P. Worley,et al.  Age-Dependent Cognitive Deficits and Neuronal Apoptosis in Cyclooxygenase-2 Transgenic Mice , 2001, The Journal of Neuroscience.

[175]  K. Wada,et al.  Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice , 2001, Physiology & Behavior.

[176]  T. Saido,et al.  Metabolic Regulation of Brain Aβ by Neprilysin , 2001, Science.

[177]  E. Godaux,et al.  Mutant Presenilins Disturb Neuronal Calcium Homeostasis in the Brain of Transgenic Mice, Decreasing the Threshold for Excitotoxicity and Facilitating Long-term Potentiation* , 2001, The Journal of Biological Chemistry.

[178]  S. Kulkarni,et al.  Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. , 2001, Free radical biology & medicine.

[179]  G. Winocur,et al.  Glucose Treatment Reduces Memory Deficits in Young Adult Rats Fed High-Fat Diets , 2001, Neurobiology of Learning and Memory.

[180]  S. Turgeon,et al.  Electrolytic lesions of the medial septum enhance latent inhibition in a conditioned taste aversion paradigm , 2001, Brain Research.

[181]  René Hen,et al.  Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice , 2001 .

[182]  M. Staufenbiel,et al.  Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model , 2000, Annals of the New York Academy of Sciences.

[183]  T. Nabeshima,et al.  Animal models of Alzheimer's disease and evaluation of anti-dementia drugs. , 2000, Pharmacology & therapeutics.

[184]  R. Haley,et al.  Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease? , 2000, Archives of neurology.

[185]  P. Caroni,et al.  Neuropathology in Mice Expressing Human α-Synuclein , 2000, The Journal of Neuroscience.

[186]  S. Pal,et al.  Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. , 2000, Journal of ethnopharmacology.

[187]  N. Berardi,et al.  Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice , 2000 .

[188]  K. Tan-No,et al.  Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency , 2000, Brain Research Bulletin.

[189]  L. Norton,et al.  Microtubule-interfering Agents Stimulate the Transcription of Cyclooxygenase-2 , 2000, The Journal of Biological Chemistry.

[190]  Fiona Crawford,et al.  Elevated Aβ and Apolipoprotein E in AβPP Transgenic Mice and Its Relationship to Amyloid Accumulation in Alzheimer’s Disease , 2000, Molecular medicine.

[191]  K. Panickar,et al.  Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess , 2000, Neuroreport.

[192]  中野 有香 Accumulation of murine amyloid β42 in a gene-dosage-dependent manner in PS1 'knock-in' mice , 2000 .

[193]  S. Paul,et al.  Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[194]  J. Miyazaki,et al.  Accumulation of murine amyloidβ42 in a gene‐dosage‐dependent manner in PS1 ‘knock‐in’ mice , 1999, The European journal of neuroscience.

[195]  K. Duff,et al.  Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits , 1999, Behavior genetics.

[196]  Haruhisa Inoue,et al.  Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation , 1999, Nature Medicine.

[197]  P. Popik,et al.  A partial agonist at strychnine-insensitive glycine sites facilitates spatial learning in aged rats. , 1999, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[198]  Y. Nomura,et al.  Senescence-accelerated mouse (SAM) as an animal model of senile dementia: pharmacological, neurochemical and molecular biological approach. , 1998, Japanese journal of pharmacology.

[199]  B. Sommer,et al.  Neuron loss in APP transgenic mice , 1998, Nature.

[200]  S. Hoyer,et al.  Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. , 1998, Behavioral neuroscience.

[201]  J. Scherrmann,et al.  Simultaneous microdialysis in brain and blood of the mouse: extracellular and intracellular brain colchicine disposition , 1998, Brain Research.

[202]  R. Butterworth,et al.  Evaluation of the Role of NMDA-Mediated Excitotoxicity in the Selective Neuronal Loss in Experimental Wernicke Encephalopathy , 1998, Experimental Neurology.

[203]  Abhimanyu Sharma,et al.  Possible Mechanism of Alprazolam-Induced Amnesia in Mice , 1998, Pharmacology.

[204]  J. Morley,et al.  Learning and memory in the SAMP8 mouse , 1997, Neuroscience & Biobehavioral Reviews.

[205]  T. Hasegawa,et al.  A concussive-like brain injury model in mice (II): selective neuronal loss in the cortex and hippocampus. , 1997, Journal of neurotrauma.

[206]  Abhimanyu Sharma,et al.  Effects of BN-50730 (PAF receptor antagonist) and physostigmine (AChE inhibitor) on learning and memory in mice. , 1997, Methods and findings in experimental and clinical pharmacology.

[207]  T. Hasegawa,et al.  A concussive-like brain injury model in mice (I): impairment in learning and memory. , 1997, Journal of neurotrauma.

[208]  D. Sparks Coronary Artery Disease, Hypertension, ApoE, and Cholesterol: A Link to Alzheimer's Disease? , 1997, Annals of the New York Academy of Sciences.

[209]  G. Cheng,et al.  Mechanism of colchicine impairment on learning and memory, and protective effect of CGP36742 in mice , 1997, Brain Research.

[210]  M. Genkova-Papazova,et al.  Effects of verapamil on electroconvulsive shock- and clonidine-induced amnesia. , 1997, Methods and findings in experimental and clinical pharmacology.

[211]  P. Langlais,et al.  The effects of lesions to thalamic lateral internal medullary lamina and posterior nuclei on learning, memory and habituation in the rat , 1997, Behavioural Brain Research.

[212]  T. Kameyama,et al.  Effects of Dynorphin A (1-13) on Carbon Monoxide-Induced Delayed Amnesia in Mice , 1997, Pharmacology Biochemistry and Behavior.

[213]  N. Conradi,et al.  Effects of prenatal alcohol exposure on activity and learning in Sprague-Dawley rats , 1996, Pharmacology Biochemistry and Behavior.

[214]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[215]  S. Younkin,et al.  Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.

[216]  P. Langlais,et al.  Neuropathology of thiamine deficiency: an update on the comparative analysis of human disorders and experimental models , 1996, Metabolic Brain Disease.

[217]  Brian J Cummings,et al.  The canine as an animal model of human aging and dementia , 1996, Neurobiology of Aging.

[218]  J. Winslow,et al.  Cholinergic modulation of a decrement in social investigation following repeated contacts between mice , 1995, Psychopharmacology.

[219]  T. Hasegawa,et al.  Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain , 1995, British journal of pharmacology.

[220]  H. Nakayama,et al.  Senile Plaques and Other Senile Changes in the Brain of an Aged American Black Bear , 1995, Veterinary pathology.

[221]  L. Mucke,et al.  Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein , 1995, Nature.

[222]  J. Morley,et al.  Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid beta protein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[223]  G. Thornicroft,et al.  Cognitive impairment and clozapine , 1994, British Journal of Psychiatry.

[224]  T. Myhrer Animal models of Alzheimer's disease: Glutamatergic denervation as an alternative approach to cholinergic denervation , 1993, Neuroscience & Biobehavioral Reviews.

[225]  V. Baracos,et al.  Dietary Lipids Influence Insulin Action a , 1993, Annals of the New York Academy of Sciences.

[226]  R. Skelton,et al.  Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze , 1992, Pharmacology Biochemistry and Behavior.

[227]  E. Friedman,et al.  Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: New findings and an interpretative review , 1990, International Journal of Developmental Neuroscience.

[228]  R. Nitsch,et al.  Effects of changes in peripheral and cerebral glucose metabolism on locomotor activity, learning and memory in adult male rats , 1990, Brain Research.

[229]  S. Gershon,et al.  Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[230]  R. Butterworth,et al.  Effect of Pyrithiamine Treatment and Subsequent Thiamine Rehabilitation on Regional Cerebral Amino Acids and Thiamine‐Dependent Enzymes , 1989, Journal of neurochemistry.

[231]  L. Squire,et al.  Memory: brain systems and behavior , 1988, Trends in Neurosciences.

[232]  J. Garthwaite,et al.  Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain , 1988, Nature.

[233]  D. Gash,et al.  Transplantation of norepinephrine neurons into aged rats improves performance of a learned task , 1988, Brain Research.

[234]  N. J. Peterson,et al.  Time-dependent neurobiological effects of colchicine administered directly into the hippocampus of rats , 1987, Brain Research.

[235]  J. Penney,et al.  Glutamate dysfunction in Alzheimer's disease: an hypothesis , 1987, Trends in Neurosciences.

[236]  J. Greenamyre The role of glutamate in neurotransmission and in neurologic disease. , 1986, Archives of neurology.

[237]  J. Carney,et al.  An unanesthetized-gerbil model of cerebral ischemia-induced behavioral changes. , 1985, Journal of pharmacological methods.

[238]  Keiichi Higuchi,et al.  A new murine model of accelerated senescence , 1981, Mechanisms of Ageing and Development.

[239]  J. D. McGaugh,et al.  Acquisition deficits induced by sodium nitrite in rats and mice , 1979, Psychopharmacology.

[240]  S. Reinis Effect of hydroxylamine on maze learning in mice. , 1970, Journal of comparative and physiological psychology.

[241]  K. Jellinger The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations. , 2013, International review of neurobiology.

[242]  A. Leo,et al.  Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert. , 2013, Journal of Alzheimer's disease : JAD.

[243]  Bruno Herculano,et al.  β-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.

[244]  Xiong Wang,et al.  Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3β and preservation of postsynaptic components. , 2013, Journal of Alzheimer's disease : JAD.

[245]  R. Maiti,et al.  Role of aqueous extract of Azadirachta indica leaves in an experimental model of Alzheimer's disease in rats , 2013, International journal of applied & basic medical research.

[246]  J. Burgos,et al.  Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment. , 2011, Journal of Alzheimer's disease : JAD.

[247]  G. Elder,et al.  Transgenic mouse models of Alzheimer's disease. , 2010, The Mount Sinai journal of medicine, New York.

[248]  H. Aisa,et al.  Gossypium herbaceam extracts attenuate ibotenic acid-induced excitotoxicity in rat hippocampus. , 2009, Journal of Alzheimer's disease : JAD.

[249]  D. Holtzman,et al.  Animal Models of Alzheimer’s Disease , 2009 .

[250]  B. Hoffer,et al.  Transgenic rodent models of Parkinson's disease. , 2008, Acta neurochirurgica. Supplement.

[251]  K. Megyeri,et al.  A new treatment regime for sodium azide to evoke experimental Alzheimer's disease for pharmacological screening , 2008 .

[252]  Ningli Wang,et al.  BMC Neuroscience BioMed Central , 2008 .

[253]  J. Wands,et al.  Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. , 2006, Journal of Alzheimer's disease : JAD.

[254]  P. Riederer,et al.  Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat. , 2006, Journal of Alzheimer's disease : JAD.

[255]  Margarida Fardilha,et al.  Sodium azide and 2-deoxy-D-glucose-induced cellular stress affects phosphorylation-dependent AbetaPP processing. , 2005, Journal of Alzheimer's disease : JAD.

[256]  I. Diamond,et al.  Recent advances in the neurobiology of alcoholism: the role of adenosine. , 2004, Pharmacology & therapeutics.

[257]  M. Parle,et al.  ANIMAL MODELS FOR TESTING MEMORY , 2004 .

[258]  S. Kulkarni,et al.  Effect of combination of insulin with dextrose, D(-) fructose and diet on learning and memory in mice , 2003 .

[259]  D. Sparks,et al.  HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier. , 2002, The journal of nutrition, health & aging.

[260]  J. Richardson,et al.  Mouse models of Alzheimer's disease: a quest for plaques and tangles. , 2002, ILAR journal.

[261]  Y. Barde,et al.  Neurotrophins are required for nerve growth during development , 2001, Nature Neuroscience.

[262]  P. Best,et al.  Ethanol, memory, and hippocampal function: A review of recent findings , 2000, Hippocampus.

[263]  T. Nabeshima,et al.  Perspectives of pharmacotherapy in Alzheimer's disease. , 1999, Japanese journal of pharmacology.

[264]  Weiming Xia,et al.  Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice , 1997, Nature Medicine.

[265]  Ashok Kumar,et al.  Effect of Mentat® , a herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats , 1995 .

[266]  M. Bentura,et al.  Pyritinol facilitates the recovery of cortical cholinergic deficits caused by nucleus basalis lesions , 1994, Journal of neural transmission. Parkinson's disease and dementia section.

[267]  T. Kameyama,et al.  Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle. , 1991, Journal of pharmacobio-dynamics.

[268]  A. Fisher,et al.  Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity. , 1986, Annual review of pharmacology and toxicology.