Projection of primary vestibular afferent fibres to the cochlear nucleus in the guinea pig

After tracing the superior branch of the vestibular nerve and the macula sacculi by means of the neuronal tracers horseradish peroxidase (HRP) and wheat germ conjugated horseradish peroxidase (WGA-HRP), a conspicuous fibre bundle running into the cochlear nucleus could be observed. The HRP-labeled axons travel caudally through the descending vestibular nucleus, enter the cochlear nucleus at a level caudal to subgroup y and terminate at cells situated between the dorsal and posteroventral cochlear nucleus. Considering recent electrophysiological studies, it is reasonable to imply that these fibres are involved with the transduction of acoustic stimuli.

[1]  J. Aran,et al.  Vestibular acoustic reception in the guinea pig: a saccular function? , 1983, Acta oto-laryngologica.

[2]  W. Warr.  Fiber degeneration following lesions in the anterior ventral cochlear nucleus of the cat. , 1966, Experimental neurology.

[3]  M. Fujii,et al.  Fixation of horseradish peroxidase reaction products with ammonium molybdate , 1984, Neuroscience Research.

[4]  D. Trune,et al.  Cytoarchitecture and saccular innervation of nucleus Y in the mouse , 1986, The Journal of comparative neurology.

[5]  T. Roberts,et al.  The localization and analysis of the responses to vibration from the isolated elasmobranch labyrinth. A contribution to the problem of the evolution of hearing in vertebrates , 1951, The Journal of physiology.

[6]  C. Aurousseau,et al.  Brainstem connections of the anterior and posterior parts of the saccule in the guinea pig. , 1987, Acta oto-laryngologica.

[7]  W. Gstoettner,et al.  Vestibular nuclear complex in the guinea pig: A cytoarchitectonic study and map in three planes , 1987, The Journal of comparative neurology.

[8]  N. Mizuno,et al.  Application of coupled oxidation reaction to electron microscopic demonstration of horseradish peroxidase: cobalt-glucose oxidase method , 1979, Brain Research.

[9]  J. Aran,et al.  Acoustic responses after total destruction of the cochlear receptor: brainstem and auditory cortex. , 1980, Science.

[10]  O. Pompeiano,et al.  The vestibular nuclei in cat. , 1957, Journal of anatomy.

[11]  G. Schneider,et al.  Projection of the auditory nerve to the medial vestibular nucleus , 1982, Neuroscience Letters.

[12]  E D Young,et al.  Responses of squirrel monkey vestibular neurons to audio-frequency sound and head vibration. , 1977, Acta oto-laryngologica.

[13]  D. T. Cody,et al.  The Averaged Inion Response Evoked by Acoustic Stimulation: Its Relation to the Saccule , 1971, The Annals of otology, rhinology, and laryngology.

[14]  M. Mesulam,et al.  Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. , 1978, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[15]  R. Fay,et al.  Sound detection and processing by teleost fishes: a critical review. , 1973, Journal of the Acoustical Society of America.

[16]  Joe C. Adams,et al.  Origins of axons in the cat's acoustic striae determined by injection of horseradish peroxidase into severed tracts , 1976, The Journal of comparative neurology.

[17]  W. Möllendorff,et al.  Handbuch der Mikroskopischen Anatomie des Menschen , 1958 .

[18]  J. Tait.  LIV. Is All Hearing Cochlear? , 1932 .

[19]  A. Perachio,et al.  Distribution of vestibular afferents that innervate the sacculus and posterior canal in the gerbil , 1986, The Journal of comparative neurology.

[20]  Frequency sensitivity and selectivity of acoustically evoked potentials after complete cochlear hair cell destruction , 1982, Brain Research.