Adiponectin, a unique adipocyte-derived factor beyond hormones.

[1]  Mike Henne.  And three's a party: lysosomes, lipid droplets, and the ER in lipid trafficking and cell homeostasis. , 2019, Current opinion in cell biology.

[2]  T. Funahashi,et al.  Adiponectin promotes muscle regeneration through binding to T-cadherin , 2019, Scientific Reports.

[3]  M. Copetti,et al.  Circulating adiponectin levels are paradoxically associated with mortality rate. A systematic review and meta-analysis. , 2018, The Journal of clinical endocrinology and metabolism.

[4]  Hitoshi Nishizawa,et al.  Low muscle quality in Japanese type 2 diabetic patients with visceral fat accumulation , 2018, Cardiovascular Diabetology.

[5]  E. Fukusaki,et al.  Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release. , 2018, JCI insight.

[6]  V. Trischitta,et al.  The Adiponectin Paradox for All-Cause and Cardiovascular Mortality , 2017, Diabetes.

[7]  T. Funahashi,et al.  The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2 , 2017, The Journal of Biological Chemistry.

[8]  T. Funahashi,et al.  Significant Association of Serum Adiponectin and Creatine Kinase-MB Levels in ST-Segment Elevation Myocardial Infarction , 2017, Journal of atherosclerosis and thrombosis.

[9]  P. Scherer,et al.  Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis , 2017, Molecular metabolism.

[10]  T. Funahashi,et al.  Adiponectin association with T‐cadherin protects against neointima proliferation and atherosclerosis , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  S. Kihara,et al.  Marked elevation of serum M2BP-adiponectin complex in men with coronary artery disease. , 2016, Atherosclerosis.

[12]  M. Copetti,et al.  The combined effect of adiponectin and resistin on all-cause mortality in patients with type 2 diabetes: Evidence of synergism with abdominal adiposity. , 2016, Atherosclerosis.

[13]  Li-Ling Wu,et al.  Circulating adiponectin levels in various malignancies: an updated meta-analysis of 107 studies , 2016, Oncotarget.

[14]  Clotilde Théry,et al.  Communication by Extracellular Vesicles: Where We Are and Where We Need to Go , 2016, Cell.

[15]  S. De Cosmo,et al.  The paradoxical association of adiponectin with mortality rate in patients with type 2 diabetes: evidence of synergism with kidney function. , 2016, Atherosclerosis.

[16]  R. Nagatomi,et al.  High circulating adiponectin levels predict decreased muscle strength among older adults aged 70 years and over: A prospective cohort study. , 2015, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[17]  S. Yokoyama,et al.  Crystal structures of the human adiponectin receptors , 2015, Nature.

[18]  T. Funahashi,et al.  Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice. , 2015, Endocrinology.

[19]  Antoine b..  La différenciation sexuelle , 2014 .

[20]  S. Yoshida,et al.  Adiponectin attenuates abdominal aortic aneurysm formation in hyperlipidemic mice. , 2014, Atherosclerosis.

[21]  Yukiko Nakamura,et al.  Ultrastructural Localization of Adiponectin protein in Vasculature of Normal and Atherosclerotic mice , 2014, Scientific Reports.

[22]  M. Quon,et al.  Modulation of adiponectin as a potential therapeutic strategy. , 2014, Atherosclerosis.

[23]  K. Kohara,et al.  CDH13 Genotype–Dependent Association of High–Molecular Weight Adiponectin With All-Cause Mortality: The J-SHIPP Study , 2014, Diabetes Care.

[24]  Y. Teo,et al.  Genetic Variation in CDH13 Is Associated With Lower Plasma Adiponectin Levels but Greater Adiponectin Sensitivity in East Asian Populations , 2013, Diabetes.

[25]  A. Sahebkar,et al.  Fibrate therapy and circulating adiponectin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. , 2013, Atherosclerosis.

[26]  S. Kihara,et al.  Adiponectin Protein Exists in Aortic Endothelial Cells , 2013, PloS one.

[27]  P. Low,et al.  Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma , 2013, Nature Communications.

[28]  Ryosuke Kikuchi,et al.  T-cadherin Is Essential for Adiponectin-mediated Revascularization* , 2013, The Journal of Biological Chemistry.

[29]  T. Funahashi,et al.  Correlation between serum C1q-adiponectin/total adiponectin ratio and polyvascular lesions detected by vascular ultrasonography in Japanese type 2 diabetics. , 2013, Metabolism: clinical and experimental.

[30]  C. Mantzoros,et al.  Associations of Total and High-Molecular-Weight Adiponectin With All-Cause and Cardiovascular Mortality in Older Persons: The Cardiovascular Health Study , 2012, Circulation.

[31]  A. Gabrielsen,et al.  High plasma adiponectin concentration is associated with all-cause mortality in patients with carotid atherosclerosis. , 2012, Atherosclerosis.

[32]  F. Clavel-Chapelon,et al.  Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study. , 2012, Carcinogenesis.

[33]  Y. Kokubo,et al.  CDH13 gene coding t‐cadherin influences variations in plasma adiponectin levels in the Japanese population , 2012, Human mutation.

[34]  M. Whooley,et al.  Adiponectin is associated with increased mortality and heart failure in patients with stable ischemic heart disease: data from the Heart and Soul Study. , 2012, Atherosclerosis.

[35]  Wen-Harn Pan,et al.  A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes , 2011, Diabetes.

[36]  P. Wilson,et al.  Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study. , 2011, Atherosclerosis.

[37]  T. Lehtimäki,et al.  A longitudinal analysis on associations of adiponectin levels with metabolic syndrome and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study. , 2011, Atherosclerosis.

[38]  S. Kihara,et al.  Dynamic Changes of Adiponectin and S100A8 Levels by the Selective Peroxisome Proliferator–Activated Receptor-&ggr; Agonist Rivoglitazone , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[39]  P. Ruiz-Lozano,et al.  T-cadherin is critical for adiponectin-mediated cardioprotection in mice. , 2010, The Journal of clinical investigation.

[40]  C. Hug,et al.  Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. , 2010, American journal of respiratory cell and molecular biology.

[41]  M. Matsuzaki,et al.  Correlation between circulating adiponectin levels and coronary plaque regression during aggressive lipid-lowering therapy in patients with acute coronary syndrome: subgroup analysis of JAPAN-ACS study. , 2010, Atherosclerosis.

[42]  K. Walsh,et al.  Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload. , 2010, American journal of physiology. Heart and circulatory physiology.

[43]  J. Skepper,et al.  Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands* , 2010, The Journal of Biological Chemistry.

[44]  S. Kihara,et al.  Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. , 2009, Cardiovascular research.

[45]  Feng Liu,et al.  Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells* , 2009, The Journal of Biological Chemistry.

[46]  W. Zhou,et al.  LKB1 is required for adiponectin-mediated modulation of AMPK–S6K axis and inhibition of migration and invasion of breast cancer cells , 2009, Oncogene.

[47]  J. Baynes,et al.  Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes , 2009, The Journal of Biological Chemistry.

[48]  T. Funahashi,et al.  Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure. , 2009, Journal of the American College of Cardiology.

[49]  A. Iyama,et al.  A cross-sectional study for glucose intolerance of myotonic dystrophy , 2009, Journal of the Neurological Sciences.

[50]  Feng Liu,et al.  A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization , 2008, Proceedings of the National Academy of Sciences.

[51]  H. Parving,et al.  Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy. , 2008, Kidney international.

[52]  B. Suki,et al.  Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[53]  M. Christ-Crain,et al.  Increase in high molecular weight adiponectin by bariatric surgery‐induced weight loss , 2008, Diabetes, obesity & metabolism.

[54]  S. Kihara,et al.  Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-&agr; , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[55]  B. Falkner,et al.  Adiponectin regulates albuminuria and podocyte function in mice. , 2008, The Journal of clinical investigation.

[56]  E. Tuzcu,et al.  Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial. , 2008, JAMA.

[57]  Petra Schwille,et al.  Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes , 2008, Science.

[58]  A. Xu,et al.  Post-translational modifications of adiponectin: mechanisms and functional implications. , 2008, The Biochemical journal.

[59]  S. Kihara,et al.  Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. , 2007, Cardiovascular research.

[60]  Hong Wang,et al.  Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα , 2007, Molecular and Cellular Biology.

[61]  P. Froguel,et al.  Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions , 2007, Nature Medicine.

[62]  D. Tanné,et al.  Effects of Peroxisome Proliferator-Activated Receptor Ligands, Bezafibrate and Fenofibrate, on Adiponectin Level , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[63]  S. Kihara,et al.  Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. , 2007, The Journal of clinical investigation.

[64]  L. Risch,et al.  Relationship between glomerular filtration rate and the adipokines adiponectin, resistin and leptin in coronary patients with predominantly normal or mildly impaired renal function. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[65]  T. Ogihara,et al.  Adiponectin and renal function, and implication as a risk of cardiovascular disease. , 2006, The American journal of cardiology.

[66]  G. Beck,et al.  Adiponectin and mortality in patients with chronic kidney disease. , 2006, Journal of the American Society of Nephrology : JASN.

[67]  A. Xu,et al.  Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. , 2006, The Journal of allergy and clinical immunology.

[68]  P. Verkade,et al.  Alzheimer's disease beta-amyloid peptides are released in association with exosomes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[69]  Feng Liu,et al.  APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function , 2006, Nature Cell Biology.

[70]  W. Willett,et al.  Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. , 2005, Journal of the National Cancer Institute.

[71]  Jan Frystyk,et al.  Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure , 2005, Circulation.

[72]  J. Couzin.  The Ins and Outs of Exosomes , 2005, Science.

[73]  C. Forsblom,et al.  Serum adiponectin is increased in type 1 diabetic patients with nephropathy. , 2005, Diabetes care.

[74]  Morihiro Matsuda,et al.  Increased oxidative stress in obesity and its impact on metabolic syndrome. , 2004, The Journal of clinical investigation.

[75]  S. Kihara,et al.  Adiponectin-mediated modulation of hypertrophic signals in the heart , 2004, Nature Medicine.

[76]  H. Lodish,et al.  T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[77]  W. Faigle,et al.  Cells release prions in association with exosomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[78]  Ming-Ming Zhou,et al.  Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. , 2004, Structure.

[79]  Cynthia J. Girman,et al.  Plasma adiponectin levels and risk of myocardial infarction in men. , 2004, JAMA.

[80]  T. Ogihara,et al.  Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. , 2004, Journal of the American College of Cardiology.

[81]  S. Kihara,et al.  Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. , 2003, Gastroenterology.

[82]  P. Froguel,et al.  Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes , 2003, Journal of Biological Chemistry.

[83]  S. Toubro,et al.  Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. , 2003, American journal of physiology. Endocrinology and metabolism.

[84]  M. Matsuda,et al.  Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. , 2003, Diabetes.

[85]  Yu Wang,et al.  The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. , 2003, The Journal of clinical investigation.

[86]  Philippe Froguel,et al.  Cloning of adiponectin receptors that mediate antidiabetic metabolic effects , 2003, Nature.

[87]  S. Kihara,et al.  Erratum , 2003, Heart.

[88]  M. Cnop,et al.  Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex , 2003, Diabetologia.

[89]  J. Engel,et al.  Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin , 2003, The Journal of Biological Chemistry.

[90]  R. Paschke,et al.  Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. , 2003, Biochemical and biophysical research communications.

[91]  S. Kihara,et al.  Association of Hypoadiponectinemia With Coronary Artery Disease in Men , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[92]  R. A. Norman,et al.  The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. , 2002, Diabetes.

[93]  M. Matsuda,et al.  Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. , 2002, Diabetes.

[94]  Jonathan Krakoff,et al.  Adiponectin and development of type 2 diabetes in the Pima Indian population , 2002, The Lancet.

[95]  M. Matsuda,et al.  Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. , 2002, Diabetes.

[96]  S. Kihara,et al.  Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell , 2002, Circulation.

[97]  M. Matsuda,et al.  Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 , 2002, Nature Medicine.

[98]  M. Matsuda,et al.  PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. , 2001, Diabetes.

[99]  Y. Terauchi,et al.  The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.

[100]  H. Lodish,et al.  Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[101]  S. Kihara,et al.  Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. , 2000, Blood.

[102]  T Nakamura,et al.  Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[103]  T Nakamura,et al.  Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. , 1999, Circulation.

[104]  T Nakamura,et al.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. , 1999, Biochemical and biophysical research communications.

[105]  L. Olson,et al.  Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterization , 1998, Mammalian Genome.

[106]  Philipp E. Scherer,et al.  The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor , 1998, Current Biology.

[107]  Y. Matsuzawa,et al.  Analysis of an expression profile of genes in the human adipose tissue. , 1997, Gene.

[108]  Y. Nakano,et al.  Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. , 1996, Journal of biochemistry.

[109]  S. Yamashita,et al.  Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty , 1996, Nature Medicine.

[110]  B. Spiegelman,et al.  AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity (*) , 1996, The Journal of Biological Chemistry.

[111]  T. Funahashi,et al.  cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). , 1996, Biochemical and biophysical research communications.

[112]  Philipp E. Scherer,et al.  A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*) , 1995, The Journal of Biological Chemistry.

[113]  T Nakamura,et al.  Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. , 1994, Atherosclerosis.

[114]  Y. Matsuzawa,et al.  Pathophysiology and Pathogenesis of Visceral Fat Obesity , 1993, Annals of the New York Academy of Sciences.

[115]  B. Ranscht,et al.  T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region , 1991, Neuron.

[116]  J. Vague.  Sexual differentiation; Factor determining forms of obesity. , 1947 .

[117]  T. Funahashi,et al.  Binding of adiponectin and C1q in human serum, and clinical significance of the measurement of C1q-adiponectin / total adiponectin ratio. , 2013, Metabolism: clinical and experimental.

[118]  M. Birnbaum,et al.  Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin , 2011, Nature Medicine.

[119]  Y. Matsuzawa,et al.  Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. , 1987, Metabolism: clinical and experimental.

[120]  Y. Matsuzawa,et al.  A novel technique for the determination of body fat by computed tomography. , 1983, International journal of obesity.