Osteopontin regulates dentin and alveolar bone development and mineralization.

[1]  A. F. Paes Leme,et al.  Microproteome of dentoalveolar tissues. , 2017, Bone.

[2]  F. Glorieux,et al.  Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia. , 2017, Bone.

[3]  C. Ge,et al.  Discoidin Receptor 2 Controls Bone Formation and Marrow Adipogenesis , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[4]  R. Kothary,et al.  Effect of genetic background on the phenotype of the Smn2B/- mouse model of spinal muscular atrophy , 2016, Human molecular genetics.

[5]  R. Reisz,et al.  Dental histology of Coelophysis bauri and the evolution of tooth attachment tissues in early dinosaurs , 2016, Journal of morphology.

[6]  A. F. Paes Leme,et al.  Global proteome profiling of dental cementum under experimentally-induced apposition. , 2016, Journal of proteomics.

[7]  B. Foster,et al.  Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption. , 2016, Matrix biology : journal of the International Society for Matrix Biology.

[8]  F. V. Winck,et al.  EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma. , 2016, Clinical science.

[9]  M. Nakatomi,et al.  Osteopontin Is Essential for Type I Collagen Secretion in Reparative Dentin , 2016, Journal of dental research.

[10]  F. Abdala,et al.  Mineralized periodontia in extinct relatives of mammals shed light on the evolutionary history of mineral homeostasis in periodontal tissue maintenance. , 2016, Journal of clinical periodontology.

[11]  C. Farquharson,et al.  Role of PHOSPHO1 in Periodontal Development and Function , 2016, Journal of dental research.

[12]  C. Lutz,et al.  Effect of genetic background on the dystrophic phenotype in mdx mice. , 2016, Human molecular genetics.

[13]  J. Millán,et al.  Alkaline Phosphatase and Hypophosphatasia , 2015, Calcified Tissue International.

[14]  M. Somerman,et al.  Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein. , 2015, Bone.

[15]  D. Holdsworth,et al.  Mechanical Forces Exacerbate Periodontal Defects in Bsp-null Mice , 2015, Journal of dental research.

[16]  J. Millán,et al.  Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis , 2014, International Journal of Oral Science.

[17]  G. Hunter,et al.  Osteopontin mediates mineralization and not osteogenic cell development in vitro. , 2014, The Biochemical journal.

[18]  J. Millán,et al.  Ablation of Osteopontin Improves the Skeletal Phenotype of Phospho1−/− Mice , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[19]  D. Magirr,et al.  Influence of genetic background on bleeding phenotype in the tail‐tip bleeding model and recommendations for standardization: communication from the SSC of the ISTH , 2014, Journal of thrombosis and haemostasis : JTH.

[20]  M. McKee,et al.  Abnormal osteopontin and matrix extracellular phosphoglycoprotein localization, and odontoblast differentiation, in X-linked hypophosphatemic teeth , 2014, Connective tissue research.

[21]  M. Somerman,et al.  Fibromodulin and Biglycan Modulate Periodontium through TGFβ/BMP Signaling , 2014, Journal of dental research.

[22]  B. Lanske,et al.  Increased Osteopontin Contributes to Inhibition of Bone Mineralization in FGF23‐Deficient Mice , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  R. Boot-Handford,et al.  Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia , 2014, PloS one.

[24]  M. Somerman,et al.  The rachitic tooth. , 2014, Endocrine reviews.

[25]  A. Kulkarni,et al.  Mouse Genetic Background Influences the Dental Phenotype , 2014, Cells Tissues Organs.

[26]  R. Reisz,et al.  Periodontal Ligament, Cementum, and Alveolar Bone in the Oldest Herbivorous Tetrapods, and Their Evolutionary Significance , 2013, PloS one.

[27]  J. Millán,et al.  In Vivo Overexpression of Tissue‐Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of Osteopontin , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[28]  M. McKee,et al.  Compounded PHOSPHO1/ALPL Deficiencies Reduce Dentin Mineralization , 2013, Journal of dental research.

[29]  M. McKee,et al.  Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X‐linked hypophosphatemia , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  M. McKee,et al.  Tooth root dentin mineralization defects in a mouse model of hypophosphatasia , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  J. Aubin,et al.  Deficiency in Acellular Cementum and Periodontal Attachment in Bsp Null Mice , 2013, Journal of dental research.

[32]  G. Hunter Role of Osteopontin in Modulation of Hydroxyapatite Formation , 2013, Calcified Tissue International.

[33]  S. Sunkara Mineralized tissues in oral and craniofacial science: biological principles and clinical correlates , 2012, BDJ.

[34]  B. Foster Methods for studying tooth root cementum by light microscopy , 2012, International Journal of Oral Science.

[35]  C. Farquharson,et al.  The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. , 2012, The Journal of endocrinology.

[36]  J. Millán,et al.  Central Role of Pyrophosphate in Acellular Cementum Formation , 2012, PloS one.

[37]  M. Ryder,et al.  Age-Related Adaptation of Bone-PDL-Tooth Complex: Rattus-Norvegicus as a Model System , 2012, PloS one.

[38]  A. Boskey,et al.  Post-translational modification of osteopontin: effects on in vitro hydroxyapatite formation and growth. , 2012, Biochemical and biophysical research communications.

[39]  B. Christensen,et al.  C-terminal Modification of Osteopontin Inhibits Interaction with the αVβ3-Integrin* , 2011, The Journal of Biological Chemistry.

[40]  R. Rutherford,et al.  The Progressive Ankylosis Protein Regulates Cementum Apposition and Extracellular Matrix Composition , 2011, Cells Tissues Organs.

[41]  T. Diekwisch,et al.  Osteopontin is required for unloading-induced osteoclast recruitment and modulation of RANKL expression during tooth drift-associated bone remodeling, but not for super-eruption. , 2010, Bone.

[42]  B. Lanske,et al.  Ablation of Systemic Phosphate‐Regulating Gene Fibroblast Growth Factor 23 (Fgf23) Compromises the Dentoalveolar Complex , 2010, Anatomical record.

[43]  I. Cuthill,et al.  Reporting : The ARRIVE Guidelines for Reporting Animal Research , 2010 .

[44]  Jeffrey J. Gray,et al.  Phosphorylation‐dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[45]  B. Lanske,et al.  Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse. , 2009, Journal of periodontology.

[46]  M. Somerman,et al.  Structure and mechanical properties of Ank/Ank mutant mouse dental tissues--an animal model for studying periodontal regeneration. , 2009, Archives of oral biology.

[47]  O. Rieppel,et al.  The mosasaur tooth attachment apparatus as paradigm for the evolution of the gnathostome periodontium , 2009, Evolution & development.

[48]  T. Doetschman Influence of genetic background on genetically engineered mouse phenotypes. , 2009, Methods in molecular biology.

[49]  M. McKee,et al.  Matrix Gla Protein Inhibition of Tooth Mineralization , 2008, Journal of dental research.

[50]  M. McKee,et al.  Avian Eggshell Structure and Osteopontin , 2008, Cells Tissues Organs.

[51]  L. Bonewald,et al.  Periodontal Breakdown in the Dmp1 Null Mouse Model of Hypophosphatemic Rickets , 2008, Journal of dental research.

[52]  C. Giachelli,et al.  The influence of surface mineral and osteopontin on the formation and function of murine bone marrow-derived osteoclasts , 2008, Journal of materials science. Materials in medicine.

[53]  C. T. Winkelmann,et al.  Role of genetic background in determining phenotypic severity throughout postnatal development and at peak bone mass in Col1a2 deficient mice (oim). , 2008, Bone.

[54]  M. Noda,et al.  OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application , 2008, Journal of cellular physiology.

[55]  L. Bonewald,et al.  Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. , 2008, Journal of periodontology.

[56]  A. Evan,et al.  Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. , 2007, American journal of physiology. Renal physiology.

[57]  M. McKee,et al.  Pyrophosphate Inhibits Mineralization of Osteoblast Cultures by Binding to Mineral, Up-regulating Osteopontin, and Inhibiting Alkaline Phosphatase Activity* , 2007, Journal of Biological Chemistry.

[58]  R. Terkeltaub,et al.  Elevated Skeletal Osteopontin Levels Contribute to the Hypophosphatasia Phenotype in Akp2−/− Mice , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  C. Guenther,et al.  Mineral Formation in Joints Caused by Complete or Joint‐Specific Loss of ANK Function , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[60]  K. Moriyama,et al.  Function and Regulation of Osteopontin in Response to Mechanical Stress , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[61]  K. Weiss,et al.  Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein family. , 2006, Journal of experimental zoology. Part B, Molecular and developmental evolution.

[62]  J. Millán Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology , 2006 .

[63]  M. McKee,et al.  Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. , 2005, Cardiovascular research.

[64]  A. Boskey,et al.  Importance of Phosphorylation for Osteopontin Regulation of Biomineralization , 2005, Calcified Tissue International.

[65]  Stan Gronthos,et al.  Investigation of multipotent postnatal stem cells from human periodontal ligament , 2004, The Lancet.

[66]  O. Baba,et al.  Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. , 2004, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[67]  Y. Saeki,et al.  Osteopontin as a positive regulator in the osteoclastogenesis of arthritis. , 2004, Biochemical and biophysical research communications.

[68]  R. Terkeltaub,et al.  Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. , 2004, The American journal of pathology.

[69]  T. Terashima,et al.  Possible role of dentin matrix in region-specific deposition of cellular and acellular extrinsic fibre cementum. , 2003, Journal of electron microscopy.

[70]  W. Young,et al.  Immunohistochemical localization of fibromodulin in the periodontium during cementogenesis and root formation in the rat molar. , 2003, Journal of periodontal research.

[71]  R. Terkeltaub,et al.  Linked Deficiencies in Extracellular PPi and Osteopontin Mediate Pathologic Calcification Associated With Defective PC‐1 and ANK Expression , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[72]  N. Fedarko,et al.  Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins , 2003, Connective tissue research.

[73]  K. Hruska,et al.  Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. , 2003, Molecular biology of the cell.

[74]  C. Alpers,et al.  J Am Soc Nephrol 14: 139–147, 2003 Osteopontin Is a Critical Inhibitor of Calcium Oxalate Crystal Formation and Retention in Renal Tubules , 2022 .

[75]  K. Hruska,et al.  The Integrin {alpha}v{beta}3 and CD44 Regulate the Actions of Osteopontin on Osteoclast Motility , 2003, Calcified Tissue International.

[76]  M. McKee,et al.  Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. , 2002, The American journal of pathology.

[77]  M. Somerman,et al.  Cementum: A Phosphate-sensitive Tissue , 2002, Journal of dental research.

[78]  C. Shuler,et al.  Caiman periodontium as an intermediate between basal vertebrate ankylosis‐type attachment and mammalian “true” periodontium , 2002, Microscopy research and technique.

[79]  R. Guldberg,et al.  Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein–deficient Mice , 2002, The Journal of experimental medicine.

[80]  M. Noda,et al.  Resistance to Unloading‐Induced Three‐Dimensional Bone Loss in Osteopontin‐Deficient Mice , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[81]  A. Boskey,et al.  Osteopontin Deficiency Increases Mineral Content and Mineral Crystallinity in Mouse Bone , 2002, Calcified Tissue International.

[82]  Masaki Noda,et al.  Enhancement of Osteoclastic Bone Resorption and Suppression of Osteoblastic Bone Formation in Response to Reduced Mechanical Stress Do Not Occur in the Absence of Osteopontin , 2001, The Journal of experimental medicine.

[83]  D. Torchia,et al.  Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. , 2001, Biochemical and biophysical research communications.

[84]  G. Hunter,et al.  Binding of Bone Sialoprotein, Osteopontin and Synthetic Polypeptides to Hydroxyapatite , 2001, Connective tissue research.

[85]  T. Doetschman,et al.  Influence of genetic background on knockout mouse phenotypes. , 2001, Methods in molecular biology.

[86]  C. Giachelli,et al.  Phosphorylation of Osteopontin Is Required for Inhibition of Vascular Smooth Muscle Cell Calcification* , 2000, The Journal of Biological Chemistry.

[87]  Y. Takano,et al.  Distribution of non-collagenous dentin matrix proteins and proteoglycans, and their relation to calcium accumulation in bisphosphonate-affected rat incisors. , 2000, European journal of oral sciences.

[88]  A. Bronckers,et al.  Blood Circulation as Source for Osteopontin in Acellular Extrinsic Fiber Cementum and Other Mineralizing Tissues , 1999, Journal of dental research.

[89]  Lynda F. Bonewald,et al.  Identification and Characterization of a Novel Protein, Periostin, with Restricted Expression to Periosteum and Periodontal Ligament and Increased Expression by Transforming Growth Factor β , 1999 .

[90]  K. Horiuchi,et al.  Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[91]  W. Beertsen,et al.  Alkaline phosphatase activity in human periodontal ligament: age effect and relation to cementum growth rate. , 1999, Journal of periodontal research.

[92]  M. Somerman,et al.  Expression of type I and XII collagen during development of the periodontal ligament in the mouse. , 1998, Archives of oral biology.

[93]  M. McKee,et al.  Mice Lacking Osteopontin Show Normal Development and Bone Structure but Display Altered Osteoclast Formation In Vitro , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[94]  G. Karsenty,et al.  Studies of osteocalcin function in dentin formation in rodent teeth. , 1998, European journal of oral sciences.

[95]  B. Hogan,et al.  Altered wound healing in mice lacking a functional osteopontin gene (spp1). , 1998, The Journal of clinical investigation.

[96]  M. McKee,et al.  Developmental appearance and distribution of bone sialoprotein and osteopontin in human and rat cementum , 1998, The Anatomical record.

[97]  G. Boivin,et al.  TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. , 1997, Development.

[98]  Y. Sasano,et al.  Expression of osteocalcin in cementoblasts forming acellular cementum. , 1997, Journal of periodontal research.

[99]  J. Millán,et al.  Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia , 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

[100]  C. McCulloch,et al.  The periodontal ligament: a unique, multifunctional connective tissue. , 1997, Periodontology 2000.

[101]  M. Somerman,et al.  Expression of bone associated markers by tooth root lining cells, in situ and in vitro. , 1997, Bone.

[102]  M. Farrall,et al.  Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice , 1997, Nature Genetics.

[103]  M. Glimcher,et al.  Phosphorylation of Purified Bovine Bone Sialoprotein and Osteopontin by Protein Kinases* , 1996, The Journal of Biological Chemistry.

[104]  P. Hauschka,et al.  Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. , 1996, The Biochemical journal.

[105]  M. McKee,et al.  Extracellular matrix in tooth cementum and mantle dentin: Localization of osteopontin and other noncollagenous proteins, plasma proteins, and glycoconjugates by electron microscopy , 1996, The Anatomical record.

[106]  W. Butler,et al.  Posttranslational modification in rat bone osteopontin. , 1996, Connective tissue research.

[107]  G. Hunter,et al.  The Inhibitory Activity of Osteopontin on Hydroxyapatite Formation In Vitro a , 1995, Annals of the New York Academy of Sciences.

[108]  V. Everts,et al.  Alkaline Phosphatase Activity in the Periodontal Ligament and Gingiva of the Rat Molar: Its Relation to Cementum Formation , 1995, Journal of dental research.

[109]  M. McKee,et al.  Postembedding colloidal‐gold immunocytochemistry of noncollagenous extracellular matrix proteins in mineralized tissues , 1995, Microscopy research and technique.

[110]  M. Somerman,et al.  Role of two mineral-associated adhesion molecules, osteopontin and bone sialoprotein, during cementogenesis. , 1995, Connective tissue research.

[111]  K. Hultenby,et al.  Disturbances of cementum formation induced by single injection of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) in rats: light and scanning electron microscopic studies. , 1994, Scandinavian journal of dental research.

[112]  G. Hunter,et al.  Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. , 1994, The Biochemical journal.

[113]  A. Bronckers,et al.  Immunolocalization of osteopontin, osteocalcin, and dentin sialoprotein during dental root formation and early cementogenesis in the rat , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[114]  V. Everts,et al.  A Quantitative Enzyme Histochemical Analysis of the Distribution of Alkaline Phosphatase Activity in the Periodontal Ligament of the Rat Incisor , 1993, Journal of dental research.

[115]  A. Boskey,et al.  Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel. , 1993, Bone and mineral.

[116]  A. Craig,et al.  Expression of attachment proteins during cementogenesis. , 1990, Journal de biologie buccale.

[117]  J. Steinfort,et al.  The Inorganic Components of Cementum- and Enamel-related Dentin in the Rat Incisor , 1990, Journal of dental research.

[118]  J. Steinfort,et al.  Differences between enamel-related and cementum-related dentin in the rat incisor with special emphasis on the phosphoproteins. , 1989, The Journal of biological chemistry.

[119]  R. Schrohenloher,et al.  Isolation, characterization, and biosynthesis of a phosphorylated glycoprotein from rat bone. , 1987, The Journal of biological chemistry.