Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of Aβ Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model
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L. Grinberg | R. Leite | C. Suemoto | S. Ferreira | R. Rodriguez | M. C. Selles | P. Reggiani | J. Fortuna | Amanda S Souza | Yasmin P. R. de Faria | Maria F. Zappa-Villar
[1] G. Casadesus,et al. The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia , 2019, Front. Aging Neurosci..
[2] M. Lewitt,et al. The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor–Binding Proteins in the Nervous System , 2019, Biochemistry insights.
[3] F. Tovar-Moll,et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models , 2018, Nature Medicine.
[4] J. Zegarra-Valdivia,et al. Serum Insulin-Like Growth Factor I Deficiency Associates to Alzheimer's Disease Co-Morbidities. , 2019, Journal of Alzheimer's disease : JAD.
[5] A. Tumminia,et al. Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications , 2018, International journal of molecular sciences.
[6] N. Barzilai,et al. 40 YEARS of IGF1 IGF1: the Jekyll and Hyde of the aging brain , 2018 .
[7] D. Munoz,et al. The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease , 2018, The Journal of pathology.
[8] A. Galina,et al. Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers , 2017, The Journal of Biological Chemistry.
[9] W. Klein,et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers , 2017, Molecular biology of the cell.
[10] M. Holzenberger,et al. The Alzheimer’s disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons , 2017, Brain : a journal of neurology.
[11] Bryan J. Neth,et al. Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial , 2017, Journal of Alzheimer's disease : JAD.
[12] F. Gomes,et al. Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice , 2017, The Journal of Biological Chemistry.
[13] L. Grinberg,et al. Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study , 2017, PLoS medicine.
[14] D. Tropea,et al. Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging , 2017, Front. Cell. Neurosci..
[15] S Lovestone,et al. Insulin signalling in Alzheimer′s disease and diabetes: from epidemiology to molecular links , 2016, Journal of internal medicine.
[16] T. Outeiro,et al. Insulin‐like growth factor‐I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats , 2016, The European journal of neuroscience.
[17] Wenhua Zheng,et al. Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer’s Disease , 2016, PloS one.
[18] G. Taglialatela,et al. The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice , 2016, Neurobiology of Aging.
[19] J. Hardy,et al. The amyloid hypothesis of Alzheimer's disease at 25 years , 2016, EMBO molecular medicine.
[20] O. Hanon,et al. Low Serum Insulin-Like Growth Factor-I Predicts Cognitive Decline in Alzheimer's Disease. , 2016, Journal of Alzheimer's disease : JAD.
[21] M. Holzenberger,et al. Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance , 2015, The Journal of Neuroscience.
[22] W. Sonntag,et al. Growth hormone, insulin-like growth factor-1 and the aging brain , 2015, Experimental Gerontology.
[23] S. Ferreira,et al. Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease , 2015, Front. Cell. Neurosci..
[24] W. Klein,et al. Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis , 2015, Acta Neuropathologica.
[25] 学 赤沢,et al. Glucose Tolerance Status and Risk of Dementia in the Community: The Hisayama Study , 2015 .
[26] Emily H. Trittschuh,et al. Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. , 2015, Journal of Alzheimer's disease : JAD.
[27] S. Ferreira,et al. Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease , 2014, Diabetes.
[28] C. DeCarli,et al. Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy , 2014, Neurology.
[29] M. Stek,et al. Insulin-like growth factor–1 and risk of late-onset Alzheimer's disease: findings from a family study , 2014, Neurobiology of Aging.
[30] M. Schubert,et al. The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications. , 2014, CNS & neurological disorders drug targets.
[31] S. Ferreira,et al. How does brain insulin resistance develop in Alzheimer's disease? , 2014, Alzheimer's & Dementia.
[32] Tzeng-Ji Chen,et al. Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study , 2014, PloS one.
[33] D. Munoz,et al. TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. , 2013, Cell metabolism.
[34] F. D. Felice. Connecting type 2 diabetes to Alzheimer's disease. , 2013 .
[35] C. Cavada,et al. Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice , 2013, Translational Psychiatry.
[36] W. Klein,et al. Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight Aβ Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers , 2013, The Journal of Neuroscience.
[37] D. Foguel,et al. Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice , 2012, Molecular Psychiatry.
[38] Suzanne Craft,et al. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.
[39] L. Mucke,et al. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. , 2012, Cold Spring Harbor perspectives in medicine.
[40] J. Schneider,et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. , 2012, The Journal of clinical investigation.
[41] F. Metzger,et al. Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency , 2012, Neuroscience Letters.
[42] T. Montine,et al. Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment A Pilot Clinical Trial , 2011 .
[43] J. Schneider,et al. National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease , 2012, Alzheimer's & Dementia.
[44] Mark A. Smith,et al. Faculty of 1000 evaluation for Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. , 2012 .
[45] S. M. de la Monte. Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease. , 2012, Drugs.
[46] W. Klein,et al. The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease , 2011, Neurobiology of Learning and Memory.
[47] S. Kanba,et al. Glucose tolerance status and risk of dementia in the community , 2011, Neurology.
[48] Charles Duyckaerts,et al. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach , 2011, Acta Neuropathologica.
[49] W. Klein,et al. Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria , 2010, PloS one.
[50] W. Klein,et al. N‐Methyl‐d‐aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid‐β peptide oligomers , 2010, Journal of neurochemistry.
[51] Ehud Cohen,et al. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection , 2010, Aging cell.
[52] Ricardo Nitrini,et al. Post-Mortem diagnosis of dementia by informant interview , 2010, Dementia & neuropsychologia.
[53] Rosemary O’Connor,et al. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling , 2010, Neurobiology of Aging.
[54] R. Castellani,et al. Alzheimer disease. , 2010, Disease-a-month : DM.
[55] E. Portiansky,et al. The ependymal route for insulin-like growth factor-1 gene therapy in the brain , 2009, Neuroscience.
[56] M. Schubert,et al. The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease. , 2009, Current Alzheimer research.
[57] W. Klein,et al. Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers , 2009, Proceedings of the National Academy of Sciences.
[58] E. Bigio,et al. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers , 2008, Neurobiology of Aging.
[59] E. Bigio,et al. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. , 2008, Neurobiology of aging.
[60] W. Klein,et al. Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine* , 2007, Journal of Biological Chemistry.
[61] E. Portiansky,et al. Restorative effect of insulin-like growth factor-I gene therapy in the hypothalamus of senile rats with dopaminergic dysfunction , 2007, Gene Therapy.
[62] E. Bigio,et al. Monoclonal antibodies that target pathological assemblies of Aβ , 2007, Journal of neurochemistry.
[63] F. Metzger,et al. Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis , 2006, Neurobiology of Aging.
[64] G. Schellenberg,et al. Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype , 2006, Neurobiology of Aging.
[65] Ricardo Nitrini,et al. Brain bank of the Brazilian aging brain study group—a milestone reached and more than 1,600 collected brains , 2006, Cell and Tissue Banking.
[66] J. Wands,et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? , 2005, Journal of Alzheimer's disease : JAD.
[67] Joanna L. Jankowsky,et al. Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase , 2004 .
[68] D. Borchelt,et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. , 2004, Human molecular genetics.
[69] Michael D. Abràmoff,et al. Image processing with ImageJ , 2004 .
[70] T. Gómez-Isla,et al. Serum insulin-like growth factor I regulates brain amyloid-β levels , 2002, Nature Medicine.
[71] A Hofman,et al. Diabetes mellitus and the risk of dementia , 1999, Neurology.
[72] B. Winblad,et al. Decreased Plasma Insulin-Like Growth Factor-I Level in Familial Alzheimer’s Disease Patients Carrying the Swedish APP 670/671 Mutation , 1999, Dementia and Geriatric Cognitive Disorders.
[73] S. Doré,et al. Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases. , 1997, Trends in neurosciences.
[74] A. Hofman,et al. Non-insulin-dependent Diabetes Mellitus (niddm) Association of Diabetes Mellitus and Dementia: the Rotterdam Study , 2022 .
[75] J. Morris. The Clinical Dementia Rating (CDR) , 1993, Neurology.
[76] M. Viitanen,et al. Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type , 1993, Journal of neural transmission. Parkinson's disease and dementia section.
[77] P. Gluckman,et al. Radioimmunoassay for insulin-like growth factor-I: solutions to some potential problems and pitfalls. , 1991, The Journal of endocrinology.