Advances in nonfouling materials: perspectives for the food industry.

Fouling of complex food components onto food-processing materials affects food quality, food safety, and operating efficiency. Developments in nonfouling and fouling-release materials for biomedical and marine applications enable the potential for adaptation to food applications; however, challenges remain. The purpose of this review is to present different strategies to prevent fouling and/or facilitate foulant removal with a critical point of view for an application of such materials on food-processing surfaces. Nonfouling, self-cleaning, and amphiphilic materials are reviewed, including an explanation of the mechanism of action, as well as inherent limitations of each technology. Perspectives on future research directions for the design of food processing surfaces with antifouling and/or fouling release properties are provided.

[1]  Jan Genzer,et al.  Development and testing of hierarchically wrinkled coatings for marine antifouling. , 2009, ACS applied materials & interfaces.

[2]  Wei Zhao,et al.  Modification of polyethersulfone ultrafiltration membranes with phosphorylcholine copolymer can remarkably improve the antifouling and permeation properties , 2008 .

[3]  Oscar Chiantore,et al.  Solution properties of poly(N‐isopropylacrylamide) , 1979 .

[4]  Tejal A Desai,et al.  Evaluation of the stability of nonfouling ultrathin poly(ethylene glycol) films for silicon-based microdevices. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[5]  L. Ista,et al.  Surface-Grafted, Environmentally Sensitive Polymers for Biofilm Release , 1999, Applied and Environmental Microbiology.

[6]  S. Minko.  Grafting on Solid Surfaces: “Grafting to” and “Grafting from” Methods , 2008 .

[7]  Marvin Y. Paik,et al.  Triblock Copolymers with Grafted Fluorine-Free, Amphiphilic, Non-Ionic Side Chains for Antifouling and Fouling-Release Applications , 2011 .

[8]  G. Whitesides,et al.  Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces , 1991, Science.

[9]  C. Lau,et al.  Perfluoroalkyl acids: a review of monitoring and toxicological findings. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[10]  I. Szleifer,et al.  Protein adsorption on surfaces with grafted polymers: a theoretical approach. , 1997, Biophysical journal.

[11]  Helmut Thissen,et al.  Effects of cloud-point grafting, chain length, and density of PEG layers on competitive adsorption of ocular proteins. , 2002, Biomaterials.

[12]  Shaoyi Jiang,et al.  Molecular simulation studies of protein interactions with zwitterionic phosphorylcholine self-assembled monolayers in the presence of water. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[13]  Teruo Okano,et al.  Nanostructured designs of biomedical materials: applications of cell sheet engineering to functional regenerative tissues and organs. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[14]  The Effect of Adding Minerals on Fouling from Whey Protein Concentrate: Development of a Model Fouling Fluid for a Plate Heat Exchanger , 2002 .

[15]  Didem Öner,et al.  Ultrahydrophobic Surfaces. Effects of Topography Length Scales on Wettability , 2000 .

[16]  T. Okano,et al.  Copolymerization of 2-carboxyisopropylacrylamide with N-isopropylacrylamide accelerates cell detachment from grafted surfaces by reducing temperature. , 2003, Biomacromolecules.

[17]  K. Tan,et al.  Surface modification of stainless steel by grafting of poly(ethylene glycol) for reduction in protein adsorption. , 2001, Biomaterials.

[18]  A. Hexemer,et al.  Anti-biofouling properties of comblike block copolymers with amphiphilic side chains. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[19]  Jens-Peter Majschak,et al.  Surface modifications – Application potential for the reduction of cleaning costs in the food processing industry , 2009 .

[20]  E. R. Fisher,et al.  Membrane Surface Modification by Plasma-Induced Polymerization of Acrylamide for Improved Surface Properties and Reduced Protein Fouling , 2003 .

[21]  S. Parkar,et al.  Evaluation of the effect of cleaning regimes on biofilms of thermophilic bacilli on stainless steel , 2004, Journal of applied microbiology.

[22]  S. Mallapragada,et al.  Comparison of Protein Fouling on Heat‐Treated Poly(vinyl alcohol), Poly(ether sulfone) and Regenerated Cellulose Membranes Using Diffuse Reflectance Infrared Fourier Transform Spectroscopy , 2001, Biotechnology progress.

[23]  S. Thayumanavan,et al.  Amphiphilicity in homopolymer surfaces reduces nonspecific protein adsorption. , 2009, Langmuir.

[24]  Changchun Liu.  Rapid fabrication of microfluidic chip with three-dimensional structures using natural lotus leaf template , 2010 .

[25]  K. Suh,et al.  Anti-biofouling Coating by Wrinkled, Dual-roughness Structures of Diamond-like Carbon (DLC) , 2009 .

[26]  C. Alexander,et al.  Thermoresponsive Surface-Grafted Poly(N−isopropylacrylamide) Copolymers: Effect of Phase Transitions on Protein and Bacterial Attachment , 2003 .

[28]  S. Manolache,et al.  Generation of antifouling layers on stainless steel surfaces by plasma-enhanced crosslinking of polyethylene glycol , 2005 .

[29]  Chao Zhao,et al.  Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical polymerization. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[30]  M. Stamm.  Polymer Surfaces and Interfaces , 2008 .

[31]  Karen L Wooley,et al.  The antifouling and fouling-release performance of hyperbranched fluoropolymer (HBFP)-poly(ethylene glycol) (PEG) composite coatings evaluated by adsorption of biomacromolecules and the green fouling alga Ulva. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[32]  R. Maheshwari,et al.  Lotus-inspired nanotechnology applications , 2008 .

[33]  Shaoyi Jiang,et al.  An New Avenue to Nonfouling Materials , 2008 .

[34]  Christopher K. Ober,et al.  Advances in polymers for anti-biofouling surfaces , 2008 .

[35]  F. Rossi,et al.  Amphiphilic Copolymer Coatings via Plasma Polymerisation Process: Switching and Anti‐Biofouling Characteristics , 2011 .

[36]  K. L. Tan,et al.  Plasma-induced immobilization of poly(ethylene glycol) onto poly(vinylidene fluoride) microporous membrane , 2002 .

[37]  M. Genet,et al.  Optimization of cryo‐XPS analyses for the study of thin films of a block copolymer (PS‐PEO) , 2012 .

[38]  Xiao Dong Chen,et al.  A Study of the Effects of Surface Chemistry on the Initial Deposition Mechanisms of Dairy Fouling , 2006 .

[39]  Kinam Park,et al.  Prevention of Protein Adsorption by Tethered Poly(ethylene oxide) Layers: Experiments and Single-Chain Mean-Field Analysis , 1998 .

[40]  Jiang Wei,et al.  Characterization of a non-fouling ultrafiltration membrane , 2006 .

[41]  M. Chaudhury,et al.  The influence of elastic modulus and thickness on the release of the soft-fouling green alga Ulva linza (syn. Enteromorpha linza ) from poly(dimethylsiloxane) (PDMS) model networks , 2005, Biofouling.

[42]  M. R. Malayeri,et al.  Application of nano‐modified surfaces for fouling mitigation , 2009 .

[43]  K. Böhringer,et al.  Derivatization of pillared silicon substrates using poly ( ethylene glycol ) and 1-dodecanethiol , 2008 .

[44]  M. Grunze,et al.  Factors that determine the protein resistance of oligoether self-assembled monolayers --internal hydrophilicity, terminal hydrophilicity, and lateral packing density. , 2003, Journal of the American Chemical Society.

[45]  J. Jasinski,et al.  Carboxybetaine, sulfobetaine, and cationic block copolymer coatings: A comparison of the surface properties and antibiofouling behavior , 2012 .

[46]  D. Brooks,et al.  Poly(oligo(ethylene glycol)acrylamide) brushes by surface initiated polymerization: effect of macromonomer chain length on brush growth and protein adsorption from blood plasma. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[47]  Yang-Tse Cheng,et al.  Effects of micro- and nano-structures on the self-cleaning behaviour of lotus leaves , 2006 .

[48]  Shiping Zhu,et al.  Non-biofouling materials prepared by atom transfer radical polymerization grafting of 2-methacryloloxyethyl phosphorylcholine: separate effects of graft density and chain length on protein repulsion. , 2006, Biomaterials.

[49]  George M. Whitesides,et al.  Surveying for Surfaces that Resist the Adsorption of Proteins , 2000 .

[50]  Markus Biesalski,et al.  Self-assembled monolayers of dendritic polyglycerol derivatives on gold that resist the adsorption of proteins. , 2004, Chemistry.

[51]  D. J. Cookson,et al.  The role of nano-roughness in antifouling , 2009, Biofouling.

[52]  Hans Müller-Steinhagen,et al.  Heat Exchanger Fouling: Environmental Impacts , 2009 .

[53]  G McHale,et al.  Nano-scale superhydrophobicity: suppression of protein adsorption and promotion of flow-induced detachment. , 2008, Lab on a chip.

[54]  P. Kingshott,et al.  Effect of polysaccharide structure on protein adsorption , 2000 .

[55]  Shaoyi Jiang,et al.  Ultra low fouling zwitterionic polymers with a biomimetic adhesive group. , 2008, Biomaterials.

[56]  S. H. Lee,et al.  Fabrication of nanostructures of polyethylene glycol for applications to protein adsorption and cell adhesion , 2005, Nanotechnology.

[57]  Qiang Sun,et al.  Enhancing the antifouling property of polyethersulfone ultrafiltration membranes through surface adsorption-crosslinking of poly(vinyl alcohol) , 2007 .

[58]  A. Halperin,et al.  Polymer Brushes that Resist Adsorption of Model Proteins: Design Parameters , 1999 .

[59]  W. Birch,et al.  Barnacle repellent nanostructured surfaces formed by the self-assembly of amphiphilic block copolymers , 2010 .

[60]  A. Karabelas,et al.  Modified stainless steel surfaces targeted to reduce fouling - Evaluation of fouling by milk components , 2007 .

[61]  W. Norde,et al.  Interaction of bovine serum albumin and human blood plasma with PEO-tethered surfaces: influence of PEO chain length, grafting density, and temperature. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[62]  Salmaan H. Baxamusa,et al.  Random Copolymer Films with Molecular‐Scale Compositional Heterogeneities that Interfere with Protein Adsorption , 2009 .

[63]  Hongwei Ma,et al.  Surface engineering strategies for control of protein and cell interactions , 2004 .

[64]  E. Chiellini,et al.  Nanostructured films of amphiphilic fluorinated block copolymers for fouling release application. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[65]  David Farrar,et al.  Quantification of surface-bound proteins by fluorometric assay: Comparison with quartz crystal microbalance and amido black assay. , 2006, The journal of physical chemistry. B.

[66]  F. Qing,et al.  Synthesis and characterization of a novel amphiphilic copolymer capable as anti‐biofouling coating material , 2009 .

[67]  Daniel G. Anderson,et al.  High throughput discovery of new fouling-resistant surfaces. , 2011, Journal of materials chemistry.

[68]  Qiang Fu,et al.  No platelet can adhere--largely improved blood compatibility on nanostructured superhydrophobic surfaces. , 2005, Small.

[69]  E. Kramer,et al.  Amphiphilic surface active triblock copolymers with mixed hydrophobic and hydrophilic side chains for tuned marine fouling-release properties. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[70]  Chung-Yuan Mou,et al.  Fabrication of Tunable Superhydrophobic Surfaces by Nanosphere Lithography , 2004 .

[71]  S. Krishnan,et al.  Polymer Thin Films for Biomedical Applications , 2011 .

[72]  C. Pradier,et al.  Grafting of lysozyme and/or poly(ethylene glycol) to prevent biofilm growth on stainless steel surfaces. , 2009, The journal of physical chemistry. B.

[73]  D. Leckband,et al.  Grafted poly(ethylene oxide) brushes as nonfouling surface coatings. , 1999, Journal of biomaterials science. Polymer edition.

[74]  Shaoyi Jiang,et al.  Functionalizable and ultra-low fouling zwitterionic surfaces via adhesive mussel mimetic linkages. , 2010, Biomaterials.

[75]  Xi Zhang,et al.  Superhydrophobic surfaces: from structural control to functional application , 2008 .

[76]  Shiping Zhu,et al.  Protein resistant surfaces: Comparison of acrylate graft polymers bearing oligo-ethylene oxide and phosphorylcholine side chains , 2006, Biointerphases.

[77]  M Morra,et al.  On the molecular basis of fouling resistance , 2000, Journal of biomaterials science. Polymer edition.

[78]  Derek C G Muir,et al.  Biological monitoring of polyfluoroalkyl substances: A review. , 2006, Environmental science & technology.

[79]  Shaoyi Jiang,et al.  Nonfouling Polymer Brushes via Surface-Initiated, Two-Component Atom Transfer Radical Polymerization , 2008 .

[80]  Zhongyi Jiang,et al.  Protein fouling resistant membrane prepared by amphiphilic pegylated polyethersulfone. , 2011, Bioresource technology.

[81]  Akon Higuchi,et al.  A highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[82]  G. Whitesides,et al.  Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers , 1993 .

[83]  Ravi S Kane,et al.  Antifouling Coatings: Recent Developments in the Design of Surfaces That Prevent Fouling by Proteins, Bacteria, and Marine Organisms , 2011, Advanced materials.

[84]  W. Barthlott,et al.  Purity of the sacred lotus, or escape from contamination in biological surfaces , 1997, Planta.

[85]  M. Grunze,et al.  Temperature Dependence of the Protein Resistance of Poly- and Oligo(ethylene glycol)-Terminated Alkanethiolate Monolayers , 2001 .

[86]  M. Chiao,et al.  Self-assembled monothiol-terminated hyperbranched polyglycerols on a gold surface: a comparative study on the structure, morphology, and protein adsorption characteristics with linear poly(ethylene glycol)s. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[87]  Hong Chen,et al.  Protein adsorption and cell adhesion/detachment behavior on dual-responsive silicon surfaces modified with poly(N-isopropylacrylamide)-block-polystyrene copolymer. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[88]  David Reinhoudt,et al.  What do we need for a superhydrophobic surface? A review on the recent progress in the preparation of superhydrophobic surfaces. , 2007, Chemical Society reviews.

[89]  Chang-Hwan Choi,et al.  Droplet evaporation of pure water and protein solution on nanostructured superhydrophobic surfaces of varying heights. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[90]  R. Lamb,et al.  Engineering nanoscale roughness on hydrophobic surface—preliminary assessment of fouling behaviour , 2005 .

[91]  K. L. Tan,et al.  Antifouling poly(vinylidene fluoride) microporous membranes prepared via plasma-induced surface grafting of poly(ethylene glycol) , 2002 .

[92]  Timmons,et al.  Non-fouling surfaces produced by gas phase pulsed plasma polymerization of an ultra low molecular weight ethylene oxide containing monomer. , 2000, Colloids and surfaces. B, Biointerfaces.

[93]  Heather Sheardown,et al.  Protein Resistance of PEG-Functionalized Dendronized Surfaces : Effect of PEG Molecular Weight and Dendron Generation , 2008 .

[94]  A. Gallardo,et al.  Smart Polymers and Their Applications as Biomaterials , 2007 .

[95]  Lei Jiang,et al.  Definition of Superhydrophobic States , 2007 .

[96]  P. Déjardin,et al.  Preadsorption of polymers on glass and silica to reduce fibrinogen adsorption. , 1989, Journal of biomedical materials research.

[97]  T. Kitayama,et al.  Terminology of polymers containing ionizable or ionic groups and of polymers containing ions (IUPAC Recommendations 2006) , 2006 .

[98]  Xuesi Chen,et al.  Novel zwitterionic poly(arylene ether sulfone)s as antifouling membrane material , 2010 .

[99]  E. Kramer,et al.  Settlement of Ulva zoospores on patterned fluorinated and PEGylated monolayer surfaces. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[100]  Shaoyi Jiang,et al.  Nonfouling behavior of polycarboxybetaine-grafted surfaces: structural and environmental effects. , 2008, Biomacromolecules.

[101]  L. Guo,et al.  Large-area roll-to-roll and roll-to-plate nanoimprint lithography: a step toward high-throughput application of continuous nanoimprinting. , 2009, ACS nano.

[102]  Zhenghong Lu,et al.  Water-stable diblock polystyrene-block-poly(2-vinyl pyridine) and diblock polystyrene-block-poly(methyl methacrylate) cylindrical patterned surfaces inhibit settlement of zoospores of the green alga Ulva. , 2009, Biomacromolecules.

[103]  Marvin Y. Paik,et al.  ABC triblock surface active block copolymer with grafted ethoxylated fluoroalkyl amphiphilic side chains for marine antifouling/fouling-release applications. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[104]  J. M. Harris,et al.  Poly(Ethylene Glycol) Chemistry , 1992 .

[105]  Yiming Cao,et al.  Enhancing antifouling property of polysulfone ultrafiltration membrane by grafting zwitterionic copolymer via UV-initiated polymerization , 2009 .

[106]  Nitin Kumar,et al.  Nanoscale protein patterning using self-assembled diblock copolymers. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[107]  C. Werner,et al.  Thermo-responsive PNiPAAm-g-PEG films for controlled cell detachment. , 2003, Biomacromolecules.

[108]  J. Genzer,et al.  Formation of surface-grafted polymeric amphiphilic coatings comprising ethylene glycol and fluorinated groups and their response to protein adsorption , 2009, Biointerphases.

[109]  Joseph D. Andrade,et al.  Protein—surface interactions in the presence of polyethylene oxide: II. Effect of protein size , 1991 .

[110]  Karen L. Wooley,et al.  Amphiphilic and hydrophobic surface patterns generated from hyperbranched fluoropolymer/linear polymer networks: Minimally adhesive coatings via the crosslinking of hyperbranched fluoropolymers , 2003 .

[111]  M. Balakrishnan,et al.  Fouling control in sugarcane juice ultrafiltration with surface modified polysulfone and polyethersulfone membranes , 2009 .

[112]  David Farrar,et al.  Interpretation of protein adsorption: surface-induced conformational changes. , 2005, Journal of the American Chemical Society.

[113]  B. Liedberg,et al.  Lateral control of protein adsorption on charged polymer gradients. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[114]  Nicolas H Voelcker,et al.  Stimuli-responsive interfaces and systems for the control of protein-surface and cell-surface interactions. , 2009, Biomaterials.

[115]  S. Flint,et al.  The growth of Bacillus stearothermophilus on stainless steel , 2001, Journal of applied microbiology.

[116]  C. Bowman,et al.  Surface-Initiated Photopolymerization of Poly(ethylene glycol) Methyl Ether Methacrylate on a Diethyldithiocarbamate-Mediated Polymer Substrate , 2002 .

[117]  M. Brook,et al.  Protein repellant silicone surfaces by covalent immobilization of poly(ethylene oxide). , 2005, Biomaterials.

[118]  William R. Paterson,et al.  Optimum cleaning cycles for heat transfer equipment undergoing fouling and ageing , 2011 .

[119]  Joseph D. Andrade,et al.  Protein—surface interactions in the presence of polyethylene oxide , 1991 .

[120]  Jian Shen,et al.  Surface modification of cellulose membranes with zwitterionic polymers for resistance to protein adsorption and platelet adhesion , 2010 .

[121]  Ronald P. Manginell,et al.  Programmed Adsorption and Release of Proteins in a Microfluidic Device , 2003, Science.

[122]  G. Whitesides,et al.  A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein , 2001 .

[123]  Marvin Y. Paik,et al.  NEXAFS Depth Profiling of Surface Segregation in Block Copolymer Thin Films , 2010 .

[124]  Shaoyi Jiang,et al.  Nonfouling Polyampholytes from an Ion-pair Comonomer with Biomimetic Adhesive Groups. , 2010, Macromolecules.

[125]  V. M. Mikhal’chuk,et al.  Antioxidative Stabilization of Polyethylene Glycol in Aqueous Solutions with Herb Phenols , 2004 .

[126]  H. Burton,et al.  Section G. Deposits from whole milk in heat treatment plant—a review and discussion , 1968, Journal of Dairy Research.

[127]  M. Morra,et al.  Non-fouling properties of polysaccharide-coated surfaces. , 1999, Journal of biomaterials science. Polymer edition.

[128]  Peter Walzel,et al.  Wetting and self-cleaning properties of artificial superhydrophobic surfaces. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[129]  Joseph F. Frank,et al.  Biofilm Formation and Control in Food Processing Facilities. , 2003, Comprehensive reviews in food science and food safety.

[130]  James D Bryers,et al.  Zwitterionic carboxybetaine polymer surfaces and their resistance to long-term biofilm formation. , 2009, Biomaterials.

[131]  George M. Whitesides,et al.  Molecular Conformation in Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers on Gold and Silver Surfaces Determines Their Ability To Resist Protein Adsorption , 1998 .

[132]  M. Soltanieh,et al.  Contribution of fouling and gel polarization during ultrafiltration of raw apple juice at industrial scale , 2010 .

[133]  Wen-Yih Chen,et al.  Hemocompatible mixed-charge copolymer brushes of pseudozwitterionic surfaces resistant to nonspecific plasma protein fouling. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[134]  Maureen A. Dyer,et al.  Protein adhesion on silicon-supported hyperbranched poly(ethylene glycol) and poly(allylamine) thin films. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[135]  H. Zuilhof,et al.  Stable protein-repellent zwitterionic polymer brushes grafted from silicon nitride. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[136]  Yang Li,et al.  Surface hydrophilization of microporous polypropylene membrane by grafting zwitterionic polymer for anti-biofouling , 2010 .

[137]  A. Hexemer,et al.  Comparison of the fouling release properties of hydrophobic fluorinated and hydrophilic PEGylated block copolymer surfaces: attachment strength of the diatom Navicula and the green alga Ulva. , 2006, Biomacromolecules.

[138]  Yan-lei Su,et al.  Controlled adsorption of bovine serum albumin on poly(acrylonitrile)-based zwitterionic membranes , 2008 .

[139]  D. Grainger,et al.  Nonfouling surfaces: a review of principles and applications for microarray capture assay designs. , 2007, Methods in molecular biology.

[140]  Shaoyi Jiang,et al.  Film thickness dependence of protein adsorption from blood serum and plasma onto poly(sulfobetaine)-grafted surfaces. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[141]  Norman Epstein,et al.  Thinking about Heat Transfer Fouling: A 5 × 5 Matrix , 1983 .

[142]  S. Tia,et al.  Fouling behavior of coconut milk at pasteurization temperatures , 2010 .

[143]  Masayuki Yamato,et al.  Ultrathin poly(N-isopropylacrylamide) grafted layer on polystyrene surfaces for cell adhesion/detachment control. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[144]  Lenora H. Brewer,et al.  Photocurable Amphiphilic Perfluoropolyether/Poly(ethylene glycol) Networks for Fouling-Release Coatings , 2011 .

[145]  D. Castner,et al.  Temperature dependent activity and structure of adsorbed proteins on plasma polymerized N-isopropyl acrylamide , 2006, Biointerphases.

[146]  E. Gil,et al.  Stimuli-reponsive polymers and their bioconjugates , 2004 .

[147]  Bipan Bansal,et al.  A Critical Review of Milk Fouling in Heat Exchangers , 2006 .

[148]  Helmut Thissen,et al.  Ultrasensitive probing of the protein resistance of PEG surfaces by secondary ion mass spectrometry. , 2002, Biomaterials.

[149]  G. López,et al.  Lower critical solubility temperature materials as biofouling release agents , 1998, Journal of Industrial Microbiology and Biotechnology.

[150]  Marvin Y. Paik,et al.  Protein adsorption resistance of anti-biofouling block copolymers containing amphiphilic side chains , 2010 .

[151]  Peter J. Fryer,et al.  A prototype cleaning map: A classification of industrial cleaning processes , 2009 .