Oncosis-inducing cyclometalated iridium(iii) complexes

A series of mitochondria-targeting cyclometalated iridium(iii) complexes activated the oncosis-specific protein porimin and calpain 1, and exhibited good inhibitory activities on a wide range of cancer types including drug-resistant cancers.

[1]  Zhe-Sheng Chen,et al.  The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials. , 2017, Chemical Society reviews.

[2]  Chengcheng Zhu,et al.  Biotin-tagged platinum(iv) complexes as targeted cytostatic agents against breast cancer cells. , 2017, Chemical communications.

[3]  L. Ji,et al.  Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes. , 2017, Chemical communications.

[4]  P A Kenny,et al.  Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells , 2017, Oncogene.

[5]  Sheng Lin,et al.  Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound , 2017, Chemical science.

[6]  P. Sadler,et al.  In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes , 2016, Angewandte Chemie.

[7]  J. Seo,et al.  Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications. , 2016, Journal of the American Chemical Society.

[8]  Hong-Xia Wang,et al.  Overcoming tumor resistance to cisplatin by cationic lipid-assisted prodrug nanoparticles. , 2016, Biomaterials.

[9]  C. Gentili,et al.  Dual mode of cell death upon the photo-irradiation of a RuII polypyridyl complex in interphase or mitosis , 2016, Chemical science.

[10]  Kangqiang Qiu,et al.  Long-Term Lysosomes Tracking with a Water-Soluble Two-Photon Phosphorescent Iridium(III) Complex. , 2016, ACS applied materials & interfaces.

[11]  Modi Wang,et al.  Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α. , 2016, Journal of medicinal chemistry.

[12]  G. Pastorin,et al.  Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance , 2016, Chemical science.

[13]  S. Lippard,et al.  The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. , 2016, Chemical reviews.

[14]  Chengcheng Zhu,et al.  Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells , 2016, Chemical science.

[15]  G. Gasser,et al.  Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy. , 2015, Angewandte Chemie.

[16]  L. Liu,et al.  Effect of melatonin on oncosis of myocardial cells in the myocardial ischemia/reperfusion injury rat and the role of the mitochondrial permeability transition pore. , 2015, Genetics and molecular research : GMR.

[17]  Guanying Li,et al.  Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents. , 2015, Biomaterials.

[18]  L. Ji,et al.  A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction. , 2015, Chemical communications.

[19]  P. Sadler,et al.  Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design , 2015, Nature Communications.

[20]  M. Hemann,et al.  Necroptosis-inducing rhenium(V) oxo complexes. , 2015, Journal of the American Chemical Society.

[21]  S. Ferrari,et al.  DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy. , 2014, Chemistry.

[22]  C. Che,et al.  Luminescent cyclometalated platinum(II) complex forms emissive intercalating adducts with double-stranded DNA and RNA: differential emissions and anticancer activities. , 2014, Angewandte Chemie.

[23]  L. Spiccia,et al.  Synthesis, characterization, and biological evaluation of new Ru(II) polypyridyl photosensitizers for photodynamic therapy. , 2014, Journal of medicinal chemistry.

[24]  Yitao Ding,et al.  Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells , 2014, BioMed research international.

[25]  S. Ferrari,et al.  A bis(dipyridophenazine)(2-(2-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) complex with anticancer action upon photodeprotection. , 2014, Angewandte Chemie.

[26]  J. Zhao,et al.  A dinuclear iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells , 2013 .

[27]  Yongmin Chang,et al.  Gadolinium complex of DO3A-benzothiazole aniline (BTA) conjugate as a theranostic agent. , 2013, Journal of medicinal chemistry.

[28]  Dik-Lung Ma,et al.  Bioactive luminescent transition-metal complexes for biomedical applications. , 2013, Angewandte Chemie.

[29]  P. Sadler,et al.  Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts , 2013, Chemistry.

[30]  Xu Cao,et al.  Cell Death Pathways in Astrocytes with a Modified Model of Oxygen-Glucose Deprivation , 2013, PloS one.

[31]  Qiang Xu,et al.  Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin , 2013, Autophagy.

[32]  Robert E. Brown,et al.  A model for cardiomyocyte cell death: insights into mechanisms of oncosis. , 2013, Experimental and molecular pathology.

[33]  Lawrence Buja,et al.  Oncosis: an important non-apoptotic mode of cell death. , 2012, Experimental and molecular pathology.

[34]  R. Abagyan,et al.  A metal-based inhibitor of tumor necrosis factor-α. , 2012, Angewandte Chemie.

[35]  Wan-ying Wu,et al.  Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90 , 2012, Journal of cellular physiology.

[36]  P. Sadler,et al.  Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor. , 2012, Angewandte Chemie.

[37]  P. Sadler,et al.  Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies. , 2012, Chemical Society reviews.

[38]  Z. Su,et al.  Iron Oxide Nanotubes for Magnetically Guided Delivery and pH‐Activated Release of Insoluble Anticancer Drugs , 2011 .

[39]  S. McKenna,et al.  Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. , 2011 .

[40]  T. He,et al.  Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. , 2011, Cancer letters.

[41]  P. Sadler,et al.  A potent trans-diimine platinum anticancer complex photoactivated by visible light. , 2010, Angewandte Chemie.

[42]  P. Vandenabeele,et al.  Molecular mechanisms of necroptosis: an ordered cellular explosion , 2010, Nature Reviews Molecular Cell Biology.

[43]  Mason R. Mackey,et al.  ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function , 2010, The Journal of Biological Chemistry.

[44]  K. Dalby,et al.  Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer , 2010, Autophagy.

[45]  N. Mizushima,et al.  Methods in Mammalian Autophagy Research , 2010, Cell.

[46]  P. Sadler,et al.  Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. , 2009, Journal of the American Chemical Society.

[47]  Na Zhang,et al.  RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis , 2009, Science.

[48]  C. Che,et al.  The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands , 2009 .

[49]  J. Geddes,et al.  N Terminus of Calpain 1 Is a Mitochondrial Targeting Sequence* , 2008, Journal of Biological Chemistry.

[50]  L. Kèlland,et al.  The resurgence of platinum-based cancer chemotherapy , 2007, Nature Reviews Cancer.

[51]  K. Kinnally,et al.  Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis? , 2006, Cell Death and Differentiation.

[52]  R A Knight,et al.  Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 , 2005, Cell Death and Differentiation.

[53]  V. Brabec,et al.  Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs. , 2005, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[54]  G. Giaccone,et al.  Cell Death Independent of Caspases: A Review , 2005, Clinical Cancer Research.

[55]  E. Sausville,et al.  FLUORINATED 2-(4-AMINO-3-METHYLPHENYL)BENZOTHIAZOLES INDUCE CYP1A1 EXPRESSION, BECOME METABOLIZED, AND BIND TO MACROMOLECULES IN SENSITIVE HUMAN CANCER CELLS , 2004, Drug Metabolism and Disposition.

[56]  G. Gores,et al.  Lysosomes in cell death , 2004, Oncogene.

[57]  A. Westwell,et al.  The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. , 2004, Current medicinal chemistry.

[58]  R. Schnellmann,et al.  The role of calpain in oncotic cell death. , 2004, Annual review of pharmacology and toxicology.

[59]  Z. Siddik,et al.  Cisplatin: mode of cytotoxic action and molecular basis of resistance , 2003, Oncogene.

[60]  S. Korsmeyer,et al.  VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis , 2003, Science.

[61]  S. Cory,et al.  The Bcl2 family: regulators of the cellular life-or-death switch , 2002, Nature Reviews Cancer.

[62]  T. Finkel,et al.  Regulation of Cellular Oncosis by Uncoupling Protein 2* , 2002, The Journal of Biological Chemistry.

[63]  Josef M. Penninger,et al.  Heat-shock protein 70 antagonizes apoptosis-inducing factor , 2001, Nature Cell Biology.

[64]  A. Liepins,et al.  Bax, Bcl-2, and NF-κB expression in sanguinarine induced bimodal cell death , 2001 .

[65]  G. Freeman,et al.  Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[66]  Xu Luo,et al.  Endonuclease G is an apoptotic DNase when released from mitochondria , 2001, Nature.

[67]  D. Bredesen,et al.  An alternative, nonapoptotic form of programmed cell death. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[68]  E. Sausville,et al.  Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells. , 2000, Cancer research.

[69]  I. Tannock,et al.  A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer , 2000, Nature Medicine.

[70]  E. Sausville,et al.  Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles. , 1999, Journal of medicinal chemistry.

[71]  P. Sadler,et al.  Metals in Medicine. , 1999, Angewandte Chemie.

[72]  W. Chan,et al.  Synthesis and Characterization of Poly(benzobisoxazole)s and Poly(benzobisthiazole)s with 2,2`-Bipyridyl Units in the Backbone , 1998 .

[73]  J. Gu,et al.  A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[74]  I. K. Berezesky,et al.  The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis , 1997, Toxicologic pathology.

[75]  G. Kroemer,et al.  Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death , 1995, The Journal of experimental medicine.

[76]  B. Trump,et al.  HgCl2-induced alteration of actin filaments in cultured primary rat proximal tubule epithelial cells labelled with fluorescein phalloidin , 1991, Cell Biology and Toxicology.

[77]  G. Majno,et al.  Apoptosis, oncosis, and necrosis. An overview of cell death. , 1995, The American journal of pathology.