Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC

[1]  D. Isaacs.  Risk , 2020, Journal of paediatrics and child health.

[2]  Yun Song,et al.  Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors , 2018, Nature Communications.

[3]  C. Zahnow,et al.  Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer , 2017, Cell.

[4]  V. Rusch,et al.  Lung cancer — major changes in the American Joint Committee on Cancer eighth edition cancer staging manual , 2017, CA: a cancer journal for clinicians.

[5]  Andreas Ziegler,et al.  ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R , 2015, 1508.04409.

[6]  X. Liu,et al.  KDM1A promotes tumor cell invasion by silencing TIMP3 in non-small cell lung cancer cells , 2016, Oncotarget.

[7]  Yang Xu,et al.  MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B , 2016, Oncotarget.

[8]  Vessela Kristensen,et al.  Genome‐wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis , 2015, Molecular oncology.

[9]  Matthew T. Maurano,et al.  Role of DNA Methylation in Modulating Transcription Factor Occupancy. , 2015, Cell reports.

[10]  R. Govindan,et al.  Genomic alterations in lung adenocarcinoma. , 2015, The Lancet. Oncology.

[11]  C. Buesa,et al.  KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. , 2015, Epigenomics.

[12]  Martin J. Aryee,et al.  Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. , 2015, Cancer discovery.

[13]  D. Christiani,et al.  A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors. , 2015, Cancer discovery.

[14]  Yi Wang,et al.  Genome-wide Association Study of Survival in Early-stage Non-Small Cell Lung Cancer , 2015, Annals of Surgical Oncology.

[15]  C. Schofield,et al.  Targeting histone lysine demethylases — Progress, challenges, and the future , 2014, Biochimica et biophysica acta.

[16]  Gangning Liang,et al.  Gene body methylation can alter gene expression and is a therapeutic target in cancer. , 2014, Cancer cell.

[17]  Johan Staaf,et al.  Genome-wide DNA Methylation Analysis of Lung Carcinoma Reveals One Neuroendocrine and Four Adenocarcinoma Epitypes Associated with Patient Outcome , 2014, Clinical Cancer Research.

[18]  S. Naber,et al.  NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. , 2014, Cancer research.

[19]  R. Janknecht,et al.  Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. , 2014, American journal of translational research.

[20]  Min Gyu Lee,et al.  Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells* , 2014, The Journal of Biological Chemistry.

[21]  A. Jemal,et al.  Cancer statistics, 2014 , 2014, CA: a cancer journal for clinicians.

[22]  Mathieu Blanchette,et al.  The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts , 2014, Genome Biology.

[23]  Min Gyu Lee,et al.  KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. , 2013, The Journal of clinical investigation.

[24]  Kristian Helin,et al.  Histone lysine demethylases as targets for anticancer therapy , 2013, Nature Reviews Drug Discovery.

[25]  M. Esteller,et al.  A prognostic DNA methylation signature for stage I non-small-cell lung cancer. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  Gad Getz,et al.  KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors , 2013, Cell.

[27]  M. Hendzel,et al.  Kdm4b Histone Demethylase Is a DNA Damage Response Protein and Confers a Survival Advantage following γ-Irradiation* , 2013, The Journal of Biological Chemistry.

[28]  R. Janknecht,et al.  KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. , 2013, Cancer research.

[29]  J. Tegnér,et al.  An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform , 2013, Epigenetics.

[30]  J. Whetstine,et al.  Tipping the lysine methylation balance in disease. , 2013, Biopolymers.

[31]  P. Park,et al.  KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. , 2013, The Journal of clinical investigation.

[32]  R. Weksberg,et al.  Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray , 2013, Epigenetics.

[33]  J. Whetstine,et al.  Histone lysine methylation dynamics: establishment, regulation, and biological impact. , 2012, Molecular cell.

[34]  M. Esteller,et al.  DNA methylation profiling in the clinic: applications and challenges , 2012, Nature Reviews Genetics.

[35]  Steven J. M. Jones,et al.  Comprehensive genomic characterization of squamous cell lung cancers , 2012, Nature.

[36]  Xihong Lin,et al.  Correction for population stratification in random forest analysis. , 2012, International journal of epidemiology.

[37]  Peter A. Jones,et al.  A decade of exploring the cancer epigenome — biological and translational implications , 2011, Nature Reviews Cancer.

[38]  Jin He,et al.  KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. , 2011, Blood.

[39]  Andrew J. Bannister,et al.  Regulation of chromatin by histone modifications , 2011, Cell Research.

[40]  E. Feierstein,et al.  DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing , 2011, PloS one.

[41]  David Lomelin,et al.  Human genetic variation recognizes functional elements in noncoding sequence. , 2010, Genome research.

[42]  David C Christiani,et al.  Second hand smoke, age of exposure and lung cancer risk. , 2007, Lung cancer.

[43]  J. Gu,et al.  High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. , 2007, Carcinogenesis.

[44]  Cheng Li,et al.  Adjusting batch effects in microarray expression data using empirical Bayes methods. , 2007, Biostatistics.

[45]  R. Millikan,et al.  Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. , 2006, American journal of human genetics.

[46]  Leo Breiman,et al.  Random Forests , 2001, Machine Learning.

[47]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.