Usefulness of bone mass measurements by photon absorptiometry.

We compared three different methods of measuring bone mass for their diagnostic value and their usefulness in follow-up measurements. The three methods were: measurement of (1) bone mineral content in the distal forearm by single photon (125I) absorptiometry, (2) bone mineral content and bone mineral density of the lumbar spine measured by dual photon (153Gd) absorptiometry, and (3) total body bone mineral and total body bone density also measured by dual photon (153Gd) absorptiometry. The diagnostic validity was evaluated from measurements on healthy premenopausal women, and three groups of postmenopausal osteoporotic women (prior forearm fracture (N = 45), prior spine fracture (N = 46), or prior hip fracture (N = 27]. The forearm measurement separated all three osteoporotic groups from the premenopausal women at least as well as the spine measurement. The value of follow-up procedures was estimated using data from a clinical trial on prevention of postmenopausal bone loss by sex hormones. Fewer participants are needed in clinical trials when a forearm scanner is used instead of a spine scanner, because of the better precision of the former. The forearm scanner seems to be the best tool of the three for bone mass measurements, in both clinical practice and for research purposes.

[1]  C. Christiansen,et al.  Long-term precision of dual photon absorptiometry in the lumbar spine in clinical settings. , 1988, Bone and mineral.

[2]  C C Glueer,et al.  Quantitative computed tomography in assessment of osteoporosis. , 1987, Seminars in nuclear medicine.

[3]  C. Christiansen,et al.  Usefulness of regional bone measurements in patients with osteoporotic fractures of the spine and distal forearm. , 1987, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  C. Christiansen,et al.  PREDICTION OF RAPID BONE LOSS IN POSTMENOPAUSAL WOMEN , 1987, The Lancet.

[5]  C. Christiansen,et al.  CYPROTERONE ACETATE, AN ALTERNATIVE GESTAGEN IN POSTMENOPAUSAL OESTROGEN/GESTAGEN THERAPY , 1987, Clinical endocrinology.

[6]  C. Christiansen,et al.  THE DIAGNOSTIC VALIDITY OF LOCAL AND TOTAL BONE MINERAL MEASUREMENTS IN POSTMENOPAUSAL OSTEOPOROSIS AND OSTEOARTHRITIS , 1986, Clinical endocrinology.

[7]  C. Christiansen,et al.  Total and local bone mass before and after normalization for indices of bone and body size. , 1986, Scandinavian journal of clinical and laboratory investigation.

[8]  C. Christiansen,et al.  INTERRELATIONSHIP BETWEEN BONE MINERAL CONTENT IN VARIOUS AREAS AND THE TOTAL BODY BY SINGLE AND DUAL PHOTON ABSORPTIOMETRY , 1985 .

[9]  C. Christiansen,et al.  Total body bone mineral in vivo by dual photon absorptiometry. II. Accuracy. , 1984, Clinical physiology.

[10]  R B Mazess,et al.  Total body bone mineral in vivo by dual photon absorptiometry. I. Measurement procedures. , 1984, Clinical physiology.

[11]  C. Christiansen,et al.  BONE MASS IN POSTMENOPAUSAL WOMEN AFTER WITHDRAWAL OF OESTROGEN/GESTAGEN REPLACEMENT THERAPY , 1981, The Lancet.

[12]  B. Riggs,et al.  Measurement of bone mineral content in human vertebrae and hip by dual photon absorptiometry. , 1980, Radiology.

[13]  S. Cohn,et al.  Measurement of total-body calcium, sodium, chlorine, nitrogen, and phosphorus in man by in vivo neutron activation analysis. , 1971, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[14]  P. Virtama,et al.  Thickness of the cortical layer as an estimate of mineral content of human finger bones. , 1960, The British journal of radiology.