Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.

[1]  A. Goldrath,et al.  Surviving the crash: transitioning from effector to memory CD8+ T cell. , 2009, Seminars in immunology.

[2]  S. Kaech,et al.  Intrinsic and extrinsic control of effector T cell survival and memory T cell development , 2009, Immunologic research.

[3]  A. Goldrath,et al.  IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. , 2008, Blood.

[4]  R. Flavell,et al.  TGF-β: A Master of All T Cell Trades , 2008, Cell.

[5]  Richard A Flavell,et al.  Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. , 2008, Immunity.

[6]  M. Roederer,et al.  T-cell quality in memory and protection: implications for vaccine design , 2008, Nature Reviews Immunology.

[7]  Surojit Sarkar,et al.  Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates , 2008, The Journal of experimental medicine.

[8]  W. Leonard,et al.  Constitutive Expression of IL-7 Receptor α Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following Listeria monocytogenes Infection1 , 2008, The Journal of Immunology.

[9]  Nikhil S. Joshi,et al.  Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation1 , 2008, The Journal of Immunology.

[10]  P. Marrack,et al.  Apoptosis and the homeostatic control of immune responses. , 2007, Current opinion in immunology.

[11]  E. Wherry,et al.  Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. , 2007, Immunity.

[12]  J. Bluestone,et al.  Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice , 2007 .

[13]  Y. Wan,et al.  Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy , 2007, Clinical Cancer Research.

[14]  Nikhil S. Joshi,et al.  Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. , 2007, Immunity.

[15]  J. Bluestone,et al.  CD3-specific antibodies: a portal to the treatment of autoimmunity , 2007, Nature Reviews Immunology.

[16]  S. Kaech,et al.  Expression of IL-7 receptor α is necessary but not sufficient for the formation of memory CD8 T cells during viral infection , 2007, Proceedings of the National Academy of Sciences.

[17]  F. Finkelman,et al.  Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis , 2007, The Journal of experimental medicine.

[18]  M. Bevan,et al.  Effector and memory CTL differentiation. , 2007, Annual review of immunology.

[19]  J. Sprent,et al.  Cytokines and T-cell homeostasis. , 2003, Current opinion in immunology.

[20]  E. Ingulli Tracing tolerance and immunity in vivo by CFSE-labeling of administered cells. , 2007, Methods in molecular biology.

[21]  J. Bluestone,et al.  Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. , 2007, Nature.

[22]  R. Flavell,et al.  Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms , 2006 .

[23]  A. Rudensky,et al.  Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. , 2006, Immunity.

[24]  T. Waldmann The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design , 2006, Nature Reviews Immunology.

[25]  David A Hildeman,et al.  Bim mediates apoptosis of CD127lo effector T cells and limits T cell memory , 2006, European journal of immunology.

[26]  C. Klebanoff,et al.  CD8+ T‐cell memory in tumor immunology and immunotherapy , 2006, Immunological reviews.

[27]  A. Tyznik,et al.  Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells , 2006, Nature.

[28]  P. Burkett,et al.  Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. , 2006, Annual review of immunology.

[29]  Richard A Flavell,et al.  Transforming growth factor-beta regulation of immune responses. , 2006, Annual review of immunology.

[30]  T. Waldmann,et al.  Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[31]  H. Kuwano,et al.  IL-15 Regulates CD8+ T Cell Contraction during Primary Infection1 , 2006, The Journal of Immunology.

[32]  J. Massagué,et al.  TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. , 2005, Cancer cell.

[33]  J. Trapani The dual adverse effects of TGF-beta secretion on tumor progression. , 2005, Cancer cell.

[34]  Leo Lefrançois,et al.  Initial T cell frequency dictates memory CD8+ T cell lineage commitment , 2005, Nature Immunology.

[35]  S. Rosenberg,et al.  TGF-β1 Attenuates the Acquisition and Expression of Effector Function by Tumor Antigen-Specific Human Memory CD8 T Cells , 2005, Journal of Immunology.

[36]  F. Sutterwala,et al.  Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. , 2005, Nature immunology.

[37]  S. Rosenberg,et al.  TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells. , 2005, Journal of immunology.

[38]  L. Lefrançois,et al.  Frontline: An in‐depth evaluation of the production of IL‐2 by antigen‐specific CD8 T cells in vivo , 2004, European journal of immunology.

[39]  J. Letterio,et al.  p21Cip1 and p27Kip1 Act in Synergy to Alter the Sensitivity of Naive T Cells to TGF-β-Mediated G1 Arrest through Modulation of IL-2 Responsiveness , 2004, The Journal of Immunology.

[40]  E John Wherry,et al.  The role of programming in memory T-cell development. , 2004, Current opinion in immunology.

[41]  T. Waldmann,et al.  IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[42]  P. Marrack,et al.  Control of T cell viability. , 2003, Annual review of immunology.

[43]  S. Korsmeyer,et al.  Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 , 2003, Nature.

[44]  L. Lefrançois,et al.  IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion 1 , 2003, The Journal of Immunology.

[45]  A. Strasser,et al.  Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[46]  E. Wherry,et al.  Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo , 2003, Nature Medicine.

[47]  P. Burkett,et al.  IL-15Rα expression on CD8+ T cells is dispensable for T cell memory , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[48]  P. Burkett,et al.  IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[49]  T. Waldmann,et al.  IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells , 2002 .

[50]  J. Killestein Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. , 2002, The New England journal of medicine.

[51]  R. Flavell,et al.  Immune-Mediated Eradication of Tumors through the Blockade of Transforming Growth Factor-beta Signaling in T Cells , 2002 .

[52]  A. Strasser,et al.  Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. , 2002, Immunity.

[53]  L. Lefrançois,et al.  Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses1 , 2002, The Journal of Immunology.

[54]  Andrew P McMahon,et al.  Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. , 2002, Developmental biology.

[55]  T. Waldmann,et al.  IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. , 2002, Immunity.

[56]  Shankar Srinivas,et al.  Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus , 2001, BMC Developmental Biology.

[57]  J. Southgate,et al.  Transforming growth factor‐β promotes ‘death by neglect’ in post‐activated human T cells , 2001, Immunology.

[58]  P. Morrissey,et al.  Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice , 2000, The Journal of experimental medicine.

[59]  R. Flavell,et al.  Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease , 2000 .

[60]  R. Flavell,et al.  Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. , 2000, Immunity.

[61]  J. Sprent,et al.  Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. , 1998, Immunity.

[62]  P. Marrack,et al.  Cytokine-induced survival of activated T cells in vitro and in vivo. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[63]  J. Altman,et al.  Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. , 1998, Immunity.

[64]  W. Leonard,et al.  The Common Cytokine Receptor γ Chain Plays an Essential Role in Regulating Lymphoid Homeostasis , 1997, The Journal of experimental medicine.

[65]  Peter C. Doherty,et al.  Virus-specific CD8+ T-cell memory determined by clonal burst size , 1994, Nature.

[66]  F. Ruscetti Biology of interleukin-2 , 1984, Survey of immunologic research.