Squamous cell carcinoma‐related antigen in children with atopic dermatitis

dermatitis (AD) has increased. Children who show exanthema over the entire body with severe itching are not rare. However, the severity of AD is not completely correlated with the levels of IgE and eosinophil counts. Soluble E-selection is now considered a good marker.1 However, the assay is not easy to carry out. There is no clinical good marker reflecting the severity of atopic dermatitis. Squamous cell carcinoma (SCC)-related antigen has been purified from human uterine cervical SCC and developed to be a tumor marker, mainly for cervical squamous cell cancer.2 The antigen is also present and expressed in normal epithelium and epithelial tissues. Squamous cell carcinomarelated antigen has been reported to be elevated in several benign lesions, including lung and skin diseases.3 In the present study, we have shown that SCC-related antigen is useful to evaluate the severity of AD in children.