[Biomarkers of alcohol abuse. Part II. New biomarkers and their interpretation].

An increasing number of new biomarkers of alcohol abuse appear in the literature. The most commonly used biomarkers (5-hydroxytryptophol, fatty acid ethyl esters, ethyl glucuronide, phosphatidyl ethanol, ethyl sulphate, mitochondrial aspartate aminotransferase, carbohydrate deficient transferrin, acetaldehyde adducts, beta-hexosaminidase, and sialic acid) were described. Then other known and less known biomarkers associated with alcohol abuse were described in brief (e.g. acetaldehyde, acetate, methanol, alpha-amino-n-butyric acid, dolichol, proteomics). Their sensitivity and specificity is generally higher than that of traditional biomarkers. The time of detection in biological fluids occur from one day to few months after alcohol consumption. Hence, their usefulness in clinical practice as well as in experimental studies is increasing.

[1]  D. Vasudevan,et al.  Biomarkers of alcoholism: an updated review , 2012, Scandinavian journal of clinical and laboratory investigation.

[2]  K. Zwierz,et al.  The effect of the binge drinking session on the activity of salivary, serum and urinary beta-hexosaminidase: preliminary data. , 2008, Alcohol and alcoholism.

[3]  K. Zwierz,et al.  The effect of acute ethanol intoxication on salivary proteins of innate and adaptive immunity. , 2008, Alcoholism, clinical and experimental research.

[4]  C. Bearer,et al.  Detection of alcohol consumption during pregnancy—Current and future biomarkers , 2007, Neuroscience & Biobehavioral Reviews.

[5]  M. Szmitkowski,et al.  [Nonoxidative metabolites of ethanol as a markers of recent alcohol drinking]. , 2007, Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.

[6]  M. Szmitkowski,et al.  Serum free sialic acid as a marker of alcohol abuse. , 2007, Alcoholism, clinical and experimental research.

[7]  O. Niemelä.  Biomarkers in alcoholism. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[8]  A. Polettini,et al.  Ethyl glucuronide and ethyl sulphate determination in serum by liquid chromatography-electrospray tandem mass spectrometry. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[9]  O. Niemelä,et al.  IgAs against acetaldehyde-modified red cell protein as a marker of ethanol consumption in male alcoholic subjects, moderate drinkers, and abstainers. , 2006, Alcoholism, clinical and experimental research.

[10]  F. Tagliaro,et al.  Carbohydrate-deficient transferrin (CDT) as a marker of alcohol abuse: a critical review of the literature 2001-2005. , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[11]  M. Szmitkowski,et al.  [New methods for the determination of transferrin isoforms in the diagnostics of alcohol abuse]. , 2006, Postepy higieny i medycyny doswiadczalnej.

[12]  F. Wurst,et al.  Detection of recent ethanol intake with new markers: comparison of fatty acid ethyl esters in serum and of ethyl glucuronide and the ratio of 5-hydroxytryptophol to 5-hydroxyindole acetic acid in urine. , 2005, Alcoholism, clinical and experimental research.

[13]  E. Taracha,et al.  Alanine aminopeptidase activity in urine: a new marker of chronic alcohol abuse? , 2004, Alcoholism, clinical and experimental research.

[14]  Karen Peterson,et al.  Biomarkers for Alcohol Use and Abuse , 2004, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[15]  A. Helander,et al.  5-hydroxytryptophol as a marker for recent alcohol intake. , 2003, Addiction.

[16]  M. Javors,et al.  Current status of carbohydrate deficient transferrin, total serum sialic acid, sialic acid index of apolipoprotein J and serum beta-hexosaminidase as markers for alcohol consumption. , 2003, Addiction.

[17]  R. Swift,et al.  Direct measurement of alcohol and its metabolites. , 2003, Addiction.

[18]  C. Spies,et al.  Use of biomarkers for alcohol use disorders in clinical practice. , 2003, Addiction.

[19]  J. Whitfield,et al.  Traditional markers of excessive alcohol use. , 2003, Addiction.

[20]  John P. Allen.  Use of biomarkers of heavy drinking in health care practice. , 2003, Military medicine.

[21]  M. Waluga,et al.  Alkoholowa choroba watroby , 2003 .

[22]  J. D. Cook.  Biochemical markers of alcohol use in pregnant women. , 2003, Clinical biochemistry.

[23]  F. Musshoff.  Chromatographic methods for the determination of markers of chronic and acute alcohol consumption. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[24]  K. Boudjeltia,et al.  Carbohydrate-deficient transferrin isoforms measured by capillary zone electrophoresis for detection of alcohol abuse. , 2002, Clinical chemistry.

[25]  C. Eriksson,et al.  Laboratory tests for acute alcohol consumption: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence. , 2002, Alcoholism, clinical and experimental research.

[26]  P. Sharpe,et al.  Biochemical detection and monitoring of alcohol abuse and abstinence , 2001, Annals of clinical biochemistry.

[27]  F. Musshoff,et al.  Determination of biological markers for alcohol abuse. , 1998, Journal of chromatography. B, Biomedical sciences and applications.

[28]  L Stowell,et al.  Comparison of serum beta-hexosaminidase isoenzyme B activity with serum carbohydrate-deficient transferrin and other markers of alcohol abuse. , 1997, Alcohol and alcoholism.

[29]  M. Laposata,et al.  Fatty acid ethyl esters: short-term and long-term serum markers of ethanol intake. , 1997, Clinical chemistry.

[30]  F. Taggi,et al.  Mitochondrial aspartate aminotransferase isoenzyme: a biochemical marker for the clinical management of alcoholics? , 1997, Clinica chimica acta; international journal of clinical chemistry.

[31]  N. R. Wright.  Breath alcohol concentrations in men 7–8 hours after prolonged, heavy drinking: influence of habitual alcohol intake , 1997, The Lancet.

[32]  D. Goldberg,et al.  Genetic markers of alcohol abuse. , 1997, Clinica chimica acta; international journal of clinical chemistry.

[33]  H Stibler,et al.  Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. , 1991, Clinical chemistry.

[34]  A. Penttilä,et al.  Methanol as a marker of alcohol abuse. , 1989, Alcoholism, clinical and experimental research.