Haptic Rendering of Biological Elastic Properties based on Biomechanical Characterization

This paper deals with the design of a micro-force sensing device for biomechanical characterization of biological samples. This device combines (SPM) techniques and advanced robotics approaches and allows to carry out in vitro prolonged observations as well as biomechanical characterization experiments. Elastic properties of biological samples are reflected to the macroscale during the mechanical characterization process by means of a haptic sensing device. Non-linear elasticity theory formalism is used in order to achieve realistic elastic rendering. Mechanical characterization experiments are conducted on human tumoral Epithilial Hella cells in order to demonstrate the efficiency and viability of the proposed system

[1]  Pasi Kallio,et al.  Multi-purpose impedance-based measurement system to automate microinjection of adherent cells , 2005, 2005 International Symposium on Computational Intelligence in Robotics and Automation.

[2]  C. S. Chen,et al.  Geometric control of cell life and death. , 1997, Science.

[3]  Ferenc Horkay,et al.  Determination of elastic moduli of thin layers of soft material using the atomic force microscope. , 2002, Biophysical journal.

[4]  Bradley J. Nelson,et al.  Mems for Cellular Force Measurements and Molecular Detection , 2004, Int. J. Inf. Acquis..

[5]  O. Sahina,et al.  High-resolution imaging of elastic properties using harmonic cantilevers , 2004 .

[6]  M. Dembo,et al.  Cell movement is guided by the rigidity of the substrate. , 2000, Biophysical journal.

[7]  Donald E Ingber,et al.  Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation. , 2002, Differentiation; research in biological diversity.

[8]  M. Girot,et al.  Enhanced Near-Field Force Probing for In Vitro Biomechanical Characterization , 2006, The First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006. BioRob 2006..

[9]  Byungkyu Kim,et al.  Mechanical force response of single living cells using a microrobotic system , 2004, IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004.

[10]  M Radmacher,et al.  Measuring the elastic properties of biological samples with the AFM. , 1997, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[11]  Manfred H. Jericho,et al.  Atomic force microscopy and theoretical considerations of surface properties and turgor pressures of bacteria , 2002 .

[12]  Jochen Guck,et al.  Stretching biological cells with light , 2002 .

[13]  Richard B. Dickinson,et al.  Measurement of long-range forces on a single yeast cell using a gradient optical trap and evanescent wave light scattering , 2003 .

[14]  Subra Suresh,et al.  The biomechanics toolbox: experimental approaches for living cells and biomolecules , 2003 .

[15]  D. Grier.  A revolution in optical manipulation , 2003, Nature.

[16]  Seonghun Park,et al.  Microscale frictional response of bovine articular cartilage from atomic force microscopy. , 2004, Journal of biomechanics.