A subset of annular lipids is linked to the flippase activity of an ABC transporter.

[1]  Lars V. Schäfer,et al.  An Annular Lipid Belt Is Essential for Allosteric Coupling and Viral Inhibition of the Antigen Translocation Complex TAP (Transporter Associated with Antigen Processing)* , 2014, The Journal of Biological Chemistry.

[2]  C. Robinson,et al.  Membrane proteins bind lipids selectively to modulate their structure and function , 2014, Nature.

[3]  P. Yeagle,et al.  Non-covalent binding of membrane lipids to membrane proteins. , 2014, Biochimica et biophysica acta.

[4]  A. Heck,et al.  Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry , 2014, Nature Protocols.

[5]  I. Rouiller,et al.  The maltose ABC transporter: action of membrane lipids on the transporter stability, coupling and ATPase activity. , 2013, Biochimica et biophysica acta.

[6]  Peter A. Edwards,et al.  Role of ABC transporters in lipid transport and human disease , 2013, Trends in Endocrinology & Metabolism.

[7]  Carol V. Robinson,et al.  Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation , 2013, Nature Communications.

[8]  A. Barr,et al.  Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states , 2013, Proceedings of the National Academy of Sciences.

[9]  P. Biggin,et al.  Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump , 2013, Proceedings of the National Academy of Sciences.

[10]  Carol V Robinson,et al.  Mass spectrometry of intact membrane protein complexes , 2013, Nature Protocols.

[11]  F. Sharom,et al.  Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates. , 2013, Biochemistry.

[12]  Ronald D. Hills,et al.  Coarse grain lipid–protein molecular interactions and diffusion with MsbA flippase , 2012, Proteins.

[13]  H. Schweizer.  Understanding efflux in Gram-negative bacteria: opportunities for drug discovery , 2012, Expert opinion on drug discovery.

[14]  M. Hohl,et al.  Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation , 2012, Nature Structural &Molecular Biology.

[15]  C. Robinson,et al.  Massign: an assignment strategy for maximizing information from the mass spectra of heterogeneous protein assemblies. , 2012, Analytical chemistry.

[16]  P. Schwille,et al.  The role of lipids in VDAC oligomerization. , 2012, Biophysical journal.

[17]  F. Sharom,et al.  Proteins that bind and move lipids: MsbA and NPC1 , 2012, Critical reviews in biochemistry and molecular biology.

[18]  Carol V. Robinson,et al.  Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding , 2011, Science.

[19]  Anthony G. Lee.  Biological membranes: the importance of molecular detail. , 2011, Trends in biochemical sciences.

[20]  William Dowhan,et al.  Lipid-protein interactions as determinants of membrane protein structure and function. , 2011, Biochemical Society transactions.

[21]  G. Dittmar,et al.  The Yeast Plasma Membrane ATP Binding Cassette (ABC) Transporter Aus1 , 2011, The Journal of Biological Chemistry.

[22]  Christer S. Ejsing,et al.  Specific Lipids Modulate the Transporter Associated with Antigen Processing (TAP)* , 2011, The Journal of Biological Chemistry.

[23]  R. Tampé,et al.  Asymmetric ATP Hydrolysis Cycle of the Heterodimeric Multidrug ABC Transport Complex TmrAB from Thermus thermophilus* , 2010, The Journal of Biological Chemistry.

[24]  L. Kenne,et al.  Structural analysis of the lipid A isolated from Hafnia alvei 32 and PCM 1192 lipopolysaccharides[S] , 2010, Journal of Lipid Research.

[25]  J. Bowie,et al.  Post-translational Modifications of Integral Membrane Proteins Resolved by Top-down Fourier Transform Mass Spectrometry with Collisionally Activated Dissociation* , 2010, Molecular & Cellular Proteomics.

[26]  Min Zhou,et al.  Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions , 2009, Nature Methods.

[27]  D. Rees,et al.  ABC transporters: the power to change , 2009, Nature Reviews Molecular Cell Biology.

[28]  L. Federici,et al.  Functional role of transmembrane helix 6 in drug binding and transport by the ABC transporter MsbA. , 2008, Biochemistry.

[29]  Jace W. Jones,et al.  Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach , 2008, Proceedings of the National Academy of Sciences.

[30]  Carol V Robinson,et al.  Micelles Protect Membrane Complexes from Solution to Vacuum , 2008, Science.

[31]  W. Tseng,et al.  A novel megaprimed and ligase-free, PCR-based, site-directed mutagenesis method. , 2008, Analytical biochemistry.

[32]  S. Chevalier,et al.  Lipid composition of membranes of Escherichia coli by liquid chromatography/tandem mass spectrometry using negative electrospray ionization. , 2007, Rapid communications in mass spectrometry : RCM.

[33]  C. Robinson,et al.  Determining the stoichiometry and interactions of macromolecular assemblies from mass spectrometry , 2007, Nature Protocols.

[34]  Ying Huang,et al.  Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells. , 2006, Cancer letters.

[35]  Shankar Subramaniam,et al.  Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 Published, JLR Papers in Press, February 14, 2006. , 2006, Journal of Lipid Research.

[36]  Andrei L. Lomize,et al.  OPM: Orientations of Proteins in Membranes database , 2006, Bioinform..

[37]  A. Driessen,et al.  Nucleotide-binding sites of the heterodimeric LmrCD ABC-multidrug transporter of Lactococcus lactis are asymmetric. , 2006, Biochemistry.

[38]  Y. Sugita,et al.  Inaugural Article: Structural role of countertransport revealed in Ca2+ pump crystal structure in the absence of Ca2+. , 2005 .

[39]  Y. Sugita,et al.  Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+). , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[40]  H. V. van Veen,et al.  Drug-Lipid A Interactions on the Escherichia coli ABC Transporter MsbA , 2005, Journal of bacteriology.

[41]  Anthony G. Lee.  How lipids and proteins interact in a membrane: a molecular approach. , 2005, Molecular bioSystems.

[42]  Igor A Kaltashov,et al.  Estimates of protein surface areas in solution by electrospray ionization mass spectrometry. , 2005, Analytical chemistry.

[43]  Jinhui Dong,et al.  Structural Basis of Energy Transduction in the Transport Cycle of MsbA , 2005, Science.

[44]  Carola Hunte,et al.  Lipids in membrane protein structures. , 2004, Biochimica et biophysica acta.

[45]  T. Janvilisri,et al.  The ATP Binding Cassette Multidrug Transporter LmrA and Lipid Transporter MsbA Have Overlapping Substrate Specificities* , 2003, Journal of Biological Chemistry.

[46]  J. Riordan,et al.  ATP Binding to the First Nucleotide Binding Domain of Multidrug Resistance-associated Protein Plays a Regulatory Role at Low Nucleotide Concentration, whereas ATP Hydrolysis at the Second Plays a Dominant Role in ATP-dependent Leukotriene C4 Transport* , 2003, Journal of Biological Chemistry.

[47]  A. Lee,et al.  Lipid-protein interactions in biological membranes: a structural perspective. , 2003, Biochimica et biophysica acta.

[48]  M. J. Lemieux,et al.  Importance of detergent and phospholipid in the crystallization of the human erythrocyte anion-exchanger membrane domain. , 2002, Journal of structural biology.

[49]  C. Robinson,et al.  A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies. , 2002, Analytical chemistry.

[50]  M. Reedy,et al.  An Escherichia coli Mutant Defective in Lipid Export* , 2001, The Journal of Biological Chemistry.

[51]  P. Borst,et al.  ABC transporters in lipid transport. , 2000, Biochimica et biophysica acta.

[52]  C. Georgopoulos,et al.  Function of Escherichia coli MsbA, an Essential ABC Family Transporter, in Lipid A and Phospholipid Biosynthesis* , 1998, The Journal of Biological Chemistry.

[53]  D. Engelman,et al.  Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles. , 1983, Journal of molecular biology.

[54]  A. Hendrich,et al.  Lipids as a target for drugs modulating multidrug resistance of cancer cells. , 2003, Current drug targets.

[55]  M. Gottesman,et al.  Multidrug resistance in cancer: role of ATP–dependent transporters , 2002, Nature Reviews Cancer.

[56]  C. Raetz,et al.  LSU Digital Commons LSU Digital Commons ATPase activity of the MsbA lipid flippase of Escherichia coli ATPase activity of the MsbA lipid flippase of Escherichia coli , 2022 .