Development and validation of a liquid chromatography-tandem mass spectroscopy method for simultaneous determination of (+)-(13aS)-deoxytylophorinine and its pharmacologically active 3-O-desmethyl metabolite in rat plasma.

[1]  Xiaohao Wang,et al.  Air flow-assisted ionization imaging mass spectrometry method for easy whole-body molecular imaging under ambient conditions. , 2013, Analytical chemistry.

[2]  P. Yu,et al.  Stereospecific Synthesis and Biological Evaluation of Monodesmethyl Metabolites of (+)-13a-(S)-Deoxytylophorinine as Potential Antitumor Agents , 2012 .

[3]  Ruiping Zhang,et al.  Integrated rapid resolution liquid chromatography-tandem mass spectrometric approach for screening and identification of metabolites of the potential anticancer agent 3,6,7-trimethoxyphenanthroindolizidine in rat urine. , 2012, Analytica chimica acta.

[4]  Lei Wang,et al.  Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents. , 2012, European journal of medicinal chemistry.

[5]  H. Lv,et al.  Synthesis, Biological Evaluation and Mechanism Studies of Deoxytylophorinine and Its Derivatives as Potential Anticancer Agents , 2012, PloS one.

[6]  H. Lv,et al.  Interaction Studies of an Anticancer Alkaloid, (+)-(13aS)-Deoxytylophorinine, with Calf Thymus DNA and Four Repeated Double-Helical DNAs , 2011, Chemotherapy.

[7]  H. Lv,et al.  Anticancer effect and neurotoxicity of S-(+)-deoxytylophorinidine, a new phenanthroindolizidine alkaloid that interacts with nucleic acids , 2011, Journal of Asian natural products research.

[8]  Shiow-Ju Lee,et al.  Anti-Inflammatory Mechanisms of Phenanthroindolizidine Alkaloids , 2006, Molecular Pharmacology.

[9]  Hongyu Zhao,et al.  Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response. , 2006, Arthritis and rheumatism.

[10]  Shishan Yu,et al.  Cytotoxic Alkaloids from the Roots of Tylophora atrofolliculata , 2004, Planta medica.

[11]  Dan Staerk,et al.  In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells. , 2002, Journal of natural products.

[12]  Sang Kook Lee,et al.  Synthesis and structure-activity studies of antofine analogues as potential anticancer agents. , 2007, Bioorganic & medicinal chemistry letters.

[13]  E. Gellert.  The Indolizidine Alkaloids , 1982 .

[14]  T. R. Govindachari,et al.  Recent Progress in the Chemistry of Phenanthroinodolizidine Alkaloids , 1978 .