Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

[1]  E. Hamel,et al.  Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver , 2012, Proceedings of the National Academy of Sciences.

[2]  D. Borchelt,et al.  Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. , 2011, Human molecular genetics.

[3]  D. Borchelt,et al.  Receptor-Associated Protein (RAP) Plays a Central Role in Modulating Aβ Deposition in APP/PS1 Transgenic Mice , 2008, PloS one.

[4]  T. Willnow,et al.  Lipoprotein receptors in Alzheimer's disease , 2006, Trends in Neurosciences.

[5]  R. Deane,et al.  RAGE (Yin) Versus LRP (Yang) Balance Regulates Alzheimer Amyloid &bgr;-Peptide Clearance Through Transport Across the Blood–Brain Barrier , 2004, Stroke.

[6]  B. Zlokovic.  Clearing amyloid through the blood–brain barrier , 2004, Journal of neurochemistry.

[7]  Sascha Weggen,et al.  FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein , 2004, The Journal of Neuroscience.

[8]  D. Holtzman,et al.  Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[9]  E. Masliah,et al.  Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein , 2002, The Journal of Neuroscience.

[10]  K. Campbell,et al.  Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy , 2002, Nature.

[11]  D. Borchelt,et al.  Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. , 2001, Human molecular genetics.

[12]  K. Willecke,et al.  hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo , 2001, Genesis.

[13]  D. Strickland,et al.  LRP: a multifunctional scavenger and signaling receptor. , 2001, The Journal of clinical investigation.

[14]  D. Borchelt,et al.  Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. , 2001, Biomolecular engineering.

[15]  B. Hyman,et al.  Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. , 2001, Brain research. Molecular brain research.

[16]  D. Holtzman,et al.  Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.

[17]  R. Katzman.,et al.  Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. , 2000, The Journal of clinical investigation.

[18]  E. Masliah,et al.  LDL receptor‐related protein (LRP) in Alzheimer's disease: Towards a unified theory of pathogenesis , 2000, Microscopy research and technique.

[19]  A. Fagan,et al.  Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model , 2000, Annals of neurology.

[20]  N. Inestrosa,et al.  Expression of α2‐macroglobulin receptor/low density lipoprotein receptor‐related protein (LRP) in rat microglial cells , 2000, Journal of neuroscience research.

[21]  B. Hyman,et al.  α2‐Macroglobulin Enhances the Clearance of Endogenous Soluble β‐Amyloid Peptide via Low‐Density Lipoprotein Receptor‐Related Protein in Cortical Neuron , 1999 .

[22]  R. Hammer,et al.  Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. , 1998, The Journal of clinical investigation.

[23]  L. Thal,et al.  Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease , 1997, Neurology.

[24]  D. Holtzman,et al.  The Low‐Density Lipoprotein Receptor‐Related Protein, a Multifunctional Apolipoprotein E Receptor, Modulates Hippocampal Neurite Development , 1997, Journal of neurochemistry.

[25]  R. Hammer,et al.  Sustained somatic gene inactivation by viral transfer of Cre recombinase , 1996, Nature Biotechnology.

[26]  D. Holtzman,et al.  Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[27]  S. Armstrong,et al.  Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[28]  H. Geuze,et al.  39 kDa receptor‐associated protein is an ER resident protein and molecular chaperone for LDL receptor‐related protein. , 1995, The EMBO journal.

[29]  B. Hyman,et al.  Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein , 1995, Annals of neurology.

[30]  D. Borchelt,et al.  Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[31]  J. Nerbonne,et al.  Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. , 1994, The Journal of biological chemistry.

[32]  T. Iwatsubo,et al.  Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43) , 1994, Neuron.

[33]  B. Hyman,et al.  Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.

[34]  R. Hammer,et al.  LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation , 1992, Cell.

[35]  P. R. Hof,et al.  An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease , 1992, Experientia.

[36]  A. Hirano,et al.  A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES , 1986, Neuropathology and applied neurobiology.

[37]  A. Hirano,et al.  Silver impregnation of nerve cells and fibers in celloidin sections. A simple impregnation technique. , 1962, Archives of neurology.

[38]  S. M. Robinson,et al.  Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. , 2009, Journal of Alzheimer's disease : JAD.

[39]  T. Golde.  Alzheimer's Research & Therapy , 2009 .

[40]  B. Hyman,et al.  Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. , 1999, Journal of neurochemistry.

[41]  T. Iwatsubo,et al.  Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). , 1994, Neuron.