Aminofutalosine Synthase (MqnE): A New Catalytic Motif in Radical SAM Enzymology.

[1]  Hung‐wen Liu,et al.  Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes. , 2018, Natural product reports.

[2]  R. D. Britt,et al.  A Radical Intermediate in Bacillus subtilis QueE during Turnover with the Substrate Analogue 6-Carboxypterin. , 2018, Journal of the American Chemical Society.

[3]  T. Begley,et al.  Mechanistic Studies on Tryptophan Lyase (NosL): Identification of Cyanide as a Reaction Product. , 2018, Journal of the American Chemical Society.

[4]  M. Stubbs,et al.  A Distinct Aromatic Prenyltransferase Associated with the Futalosine Pathway , 2017 .

[5]  John A Gerlt,et al.  Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence–Function Space and Genome Context to Discover Novel Functions , 2017, Biochemistry.

[6]  T. Begley,et al.  Aminofutalosine Synthase: Evidence for Captodative and Aryl Radical Intermediates Using β-Scission and SRN1 Trapping Reactions. , 2017, Journal of the American Chemical Society.

[7]  O. Klimmek,et al.  A class C radical S‐adenosylmethionine methyltransferase synthesizes 8‐methylmenaquinone , 2017, Molecular microbiology.

[8]  R. Müller,et al.  Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme. , 2017, Journal of the American Chemical Society.

[9]  Silvio C. E. Tosatto,et al.  InterPro in 2017—beyond protein family and domain annotations , 2016, Nucleic Acids Res..

[10]  T. Begley,et al.  Tryptophan Lyase (NosL): A Cornucopia of 5'-Deoxyadenosyl Radical Mediated Transformations. , 2016, Journal of the American Chemical Society.

[11]  G. Evans,et al.  Neutron structures of the Helicobacter pylori 5′-methylthioadenosine nucleosidase highlight proton sharing and protonation states , 2016, Proceedings of the National Academy of Sciences.

[12]  Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways. , 2016, ACS chemical biology.

[13]  I. Thiele,et al.  Genomic Analysis of the Human Gut Microbiome Suggests Novel Enzymes Involved in Quinone Biosynthesis , 2016, Front. Microbiol..

[14]  P. Kiley,et al.  How Is Fe-S Cluster Formation Regulated? , 2015, Annual review of microbiology.

[15]  J. Fontecilla-Camps,et al.  Tryptophan Lyase (NosL): Mechanistic Insights from Substrate Analogues and Mutagenesis. , 2015, Biochemistry.

[16]  T. Begley,et al.  Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions* , 2014, The Journal of Biological Chemistry.

[17]  E. Takano,et al.  Ribosylhopane, a Novel Bacterial Hopanoid, as Precursor of C35 Bacteriohopanepolyols in Streptomyces coelicolor A3(2) , 2014, Chembiochem : a European journal of chemical biology.

[18]  T. Begley,et al.  Molybdopterin Biosynthesis: Trapping of Intermediates for the MoaA-Catalyzed Reaction Using 2′-DeoxyGTP and 2′-ChloroGTP as Substrate Analogues. , 2014, Journal of the American Chemical Society.

[19]  J. Broderick,et al.  Radical S-Adenosylmethionine Enzymes , 2014, Chemical reviews.

[20]  R. Green,et al.  One-dimensional SDS-polyacrylamide gel electrophoresis (1D SDS-PAGE). , 2014, Methods in enzymology.

[21]  E. J. Rogers,et al.  Transformation of chemically competent E. coli. , 2013, Methods in enzymology.

[22]  T. Begley,et al.  Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. , 2013, Journal of the American Chemical Society.

[23]  A. Sali,et al.  Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes. , 2013, Biochemistry.

[24]  In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone. , 2013, Biochemistry.

[25]  J. Fontecilla-Camps,et al.  X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters , 2013, Proceedings of the National Academy of Sciences.

[26]  J. Lessard.  Transformation of E. coli via electroporation. , 2013, Methods in enzymology.

[27]  M. Newcomb.  Radical Kinetics and Clocks , 2012 .

[28]  C. Krebs,et al.  RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins. , 2012, Methods in enzymology.

[29]  M. Tanner,et al.  5′-Methylthioadenosine Nucleosidase Is Implicated in Playing a Key Role in a Modified Futalosine Pathway for Menaquinone Biosynthesis in Campylobacter jejuni* , 2011, The Journal of Biological Chemistry.

[30]  C. Drennan,et al.  Structural insights into radical generation by the radical SAM superfamily. , 2011, Chemical reviews.

[31]  T. Dairi,et al.  Enzymatic Properties of Futalosine Hydrolase, an Enzyme Essential to a Newly Identified Menaquinone Biosynthetic Pathway , 2009, Bioscience, biotechnology, and biochemistry.

[32]  Jun Ishikawa,et al.  An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms , 2008, Science.

[33]  H. Schindelin,et al.  Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  R. Rossi,et al.  Nucleophilic substitution reactions by electron transfer. , 2003, Chemical reviews.

[35]  Jorge F. Reyes-Spindola,et al.  Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. , 2001, Nucleic acids research.

[36]  C. Roessner,et al.  Overcoming product inhibition of S-Adenosyl-L-methionine (SAM) synthetase: Preparation of SAM on the 30 mM scale , 1995 .

[37]  W. Hagen,et al.  A spectroelectrochemical study of factor F430 nickel(II/I) from methanogenic bacteria in aqueous solution , 1993 .

[38]  J. Chen,et al.  Fragmentation of substituted acetophenones and halobenzophenone ketyls. Calibration of a mechanistic probe , 1991 .

[39]  G. D. Markham,et al.  The sequence of metK, the structural gene for S-adenosylmethionine synthetase in Escherichia coli. , 1984, The Journal of biological chemistry.

[40]  H. Beinert,et al.  Evidence for the formation of a linear [3Fe-4S] cluster in partially unfolded aconitase. , 1984, The Journal of biological chemistry.

[41]  R. Borchardt,et al.  Chiral instability at sulfur of S-adenosylmethionine. , 1983, Biochemistry.

[42]  H. Beinert.  Semi-micro methods for analysis of labile sulfide and of labile sulfide plus sulfane sulfur in unusually stable iron-sulfur proteins. , 1983, Analytical biochemistry.

[43]  M. J. Lindstrom,et al.  Photochemistry of .delta.-haloketones: anchimeric assistance in triplet-state .gamma.-hydrogen abstraction and .beta.-elimination of halogen atoms from the resulting diradicals , 1981 .

[44]  S. Mayhew.  The redox potential of dithionite and SO-2 from equilibrium reactions with flavodoxins, methyl viologen and hydrogen plus hydrogenase. , 1978, European journal of biochemistry.

[45]  H. Beinert,et al.  Micro methods for the quantitative determination of iron and copper in biological material. , 1967, Methods in enzymology.

[46]  A. Zehnder,et al.  Titanium (III) citrate as a nontoxic oxidation-reduction buffering system for the culture of obligate anaerobes. , 1976, Science.