The Na+–H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

[1]  K. V. van Golen,et al.  Rho-Regulatory Proteins in Breast Cancer Cell Motility and Invasion , 2004, Breast Cancer Research and Treatment.

[2]  David E. Williams,et al.  The Tumor Invasion Inhibitor Dihydromotuporamine C Activates RHO, Remodels Stress Fibers and Focal Adhesions, and Stimulates Sodium–Proton Exchange , 2004, Cancer Research.

[3]  B. Nürnberg,et al.  Rho GTPases and Phosphoinositide 3-Kinase Organize Formation of Branched Dendrites* , 2004, Journal of Biological Chemistry.

[4]  Yue Zhang,et al.  Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation , 2003, Science.

[5]  V. Braga,et al.  Tumor progression: Small GTPases and loss of cell-cell adhesion. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[6]  Erika S Wittchen,et al.  NZO-3 expression causes global changes to actin cytoskeleton in Madin-Darby canine kidney cells: linking a tight junction protein to Rho GTPases. , 2003, Molecular biology of the cell.

[7]  D. Bar-Sagi,et al.  Redox-dependent downregulation of Rho by Rac , 2003, Nature Cell Biology.

[8]  D. Barber,et al.  Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1 , 2002, The Journal of cell biology.

[9]  D. Schlaepfer,et al.  v-Src SH3-enhanced Interaction with Focal Adhesion Kinase at β1 Integrin-containing Invadopodia Promotes Cell Invasion* , 2002, The Journal of Biological Chemistry.

[10]  V. Brunton,et al.  Advances in Rho-dependent actin regulation and oncogenic transformation. , 2002, Current opinion in genetics & development.

[11]  M. Tatsuta,et al.  Involvement of phosphorylation of tyr‐31 and tyr‐118 of paxillin in MM1 cancer cell migration , 2002, International journal of cancer.

[12]  A. Ridley,et al.  Rho family proteins: coordinating cell responses. , 2001, Trends in cell biology.

[13]  S. Shenolikar,et al.  Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation , 2001, Oncogene.

[14]  B. Gumbiner,et al.  Cadherin Engagement Regulates Rho family GTPases* , 2001, The Journal of Biological Chemistry.

[15]  Elise C. Kohn,et al.  The microenvironment of the tumour–host interface , 2001, Nature.

[16]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[17]  D. Barber,et al.  Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. , 2000, Molecular cell.

[18]  I. Nabi,et al.  Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1. , 2000, Journal of cell science.

[19]  K. Burridge,et al.  P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases , 2000, The Journal of cell biology.

[20]  M J Bissell,et al.  The influence of the microenvironment on the malignant phenotype. , 2000, Molecular medicine today.

[21]  R. Assoian,et al.  A growing role for Rho family GTPases as intermediaries in growth factor- and adhesion-dependent cell cycle progression. , 2000, Biochimica et biophysica acta.

[22]  W. Arthur,et al.  Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism , 2000, Current Biology.

[23]  John G. Collard,et al.  Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition , 2000, The Journal of cell biology.

[24]  S. Alper,et al.  Polarization of Na+/H+ and Cl−/Hco 3 − Exchangers in Migrating Renal Epithelial Cells , 2000, The Journal of general physiology.

[25]  L. Van Aelst,et al.  ADP-Ribosylation Factor 6 Regulates Actin Cytoskeleton Remodeling in Coordination with Rac1 and RhoA , 2000, Molecular and Cellular Biology.

[26]  R. Moon,et al.  Cell regulation: Cellular aspects of signal transduction: Editorial overview , 2000 .

[27]  A. Paradiso,et al.  Phosphoinositide 3-Kinase Is Involved in the Tumor-specific Activation of Human Breast Cancer Cell Na+/H+Exchange, Motility, and Invasion Induced by Serum Deprivation* , 2000, The Journal of Biological Chemistry.

[28]  J. Parsons,et al.  Cell Migration--Movin' On , 1999, Science.

[29]  S. Grinstein,et al.  The Apical Na+/H+ Exchanger Isoform NHE3 Is Regulated by the Actin Cytoskeleton* , 1999, The Journal of Biological Chemistry.

[30]  U. Hämmerling,et al.  F-actin as a functional target for retro-retinoids: a potential role in anhydroretinol-triggered cell death. , 1999, Journal of cell science.

[31]  C. Paraskeva,et al.  An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis , 1999, Oncogene.

[32]  K. Itoh,et al.  Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. , 1999, Cancer research.

[33]  K. Burridge.  Crosstalk Between Rac and Rho , 1999, Science.

[34]  Alan Hall,et al.  Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement , 1999, The Journal of cell biology.

[35]  R. Treisman,et al.  Transformation mediated by RhoA requires activity of ROCK kinases , 1999, Current Biology.

[36]  Shuh Narumiya,et al.  An essential part for Rho–associated kinase in the transcellular invasion of tumor cells , 1999, Nature Medicine.

[37]  D. Barber,et al.  p160ROCK mediates RhoA activation of Na–H exchange , 1998, The EMBO journal.

[38]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[39]  I. Tannock,et al.  Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. , 1992, Cancer research.

[40]  R. Hill,et al.  Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion , 2004, Clinical & Experimental Metastasis.

[41]  Mu-ming Poo,et al.  Signalling and crosstalk of Rho GTPases in mediating axon guidance , 2003, Nature Cell Biology.

[42]  P. Coopman,et al.  Invadopodia: unique methods for measurement of extracellular matrix degradation in vitro. , 2001, Methods in cell biology.

[43]  John G. Collard,et al.  Rho-like GTPases in tumor cell invasion. , 2000, Methods in enzymology.

[44]  A. Chambers.  The metastatic process: basic research and clinical implications. , 1999, Oncology research.