The homeodomain of Tinman mediates homo- and heterodimerization of NK proteins.
暂无分享,去创建一个
[1] H. Watada,et al. Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[2] R. Cripps,et al. Transcription of the myogenic regulatory gene Mef2 in cardiac, somatic, and visceral muscle cell lineages is regulated by a Tinman-dependent core enhancer. , 1999, Developmental biology.
[3] J. Seidman,et al. Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease. , 2000, The Journal of clinical investigation.
[4] M. Frasch,et al. Cardiogenesis in the Drosophila model: control mechanisms during early induction and diversification of cardiac progenitors. , 2002, Cold Spring Harbor symposia on quantitative biology.
[5] R. Schulz,et al. Tinman Regulates the Transcription of the β3 tubulin Gene (βTub60D) in the Dorsal Vessel of Drosophila , 1999 .
[6] H. Sink. Muscle development in drosophila , 2006 .
[7] M. Fishman,et al. Parsing the Heart: Genetic Modules for Organ Assembly , 1997, Cell.
[8] Y. Hiroi,et al. Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease. , 2002, Circulation journal : official journal of the Japanese Circulation Society.
[9] L Hartley,et al. Authors' correction: Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants , 1993 .
[10] L Hartley,et al. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. , 1993, Development.
[11] P. Krieg,et al. tinman-related genes expressed during heart development in Xenopus. , 1998, Developmental genetics.
[12] D. Srivastava,et al. Molecular Pathways Controlling Heart Development , 1996, Science.
[13] J. Seidman,et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. , 1998, Science.
[14] R J Schwartz,et al. Identification of Novel DNA Binding Targets and Regulatory Domains of a Murine Tinman Homeodomain Factor, nkx-2.5(*) , 1995, The Journal of Biological Chemistry.
[15] D. Sparrow,et al. Early steps in vertebrate cardiogenesis. , 1997, Current opinion in genetics & development.
[16] Wei Yan,et al. Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. , 1998, Development.
[17] M. Frasch,et al. Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction , 2005, Development.
[18] M. Nirenberg,et al. Elongation of helix III of the NK-2 homeodomain upon binding to DNA: a secondary structure study by NMR. , 1994, Biochemistry.
[19] C. Desplan,et al. Cooperative dimerization of paired class homeo domains on DNA. , 1993, Genes & development.
[20] M. Frasch,et al. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. , 1998, Genes & development.
[21] R. Harvey. NK-2 homeobox genes and heart development. , 1996, Developmental biology.
[22] J. Seidman,et al. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. , 1999, The Journal of clinical investigation.
[23] I. Komuro,et al. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[24] R. Bodmer. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. , 1993, Development.
[25] M. Frasch,et al. tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. , 1993, Genes & development.
[26] S. Izumo,et al. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. , 1999, Development.
[27] S. Izumo,et al. Nkx2.5 and Nkx2.6, Homologs ofDrosophila tinman, Are Required for Development of the Pharynx , 2001, Molecular and Cellular Biology.
[28] S. Fields,et al. Elimination of false positives that arise in using the two-hybrid system. , 1993, BioTechniques.
[29] M. Frasch,et al. Early Signals in Cardiac Development , 2002, Circulation research.
[30] C. Biben,et al. Expression of NK-2 class homeobox gene Nkx2–6 in foregut endoderm and heart , 1998, Mechanisms of Development.
[31] T. Lufkin,et al. Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos , 1997, Mechanisms of Development.
[32] C Q Doe,et al. Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. , 1998, Genes & development.
[33] M. Frasch,et al. Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo , 1995, Nature.
[34] C. Desplan,et al. Homeodomain Proteins: Cooperating to be different , 1995, Current Biology.
[35] A. Lassar,et al. Induction of avian cardiac myogenesis by anterior endoderm. , 1995, Development.
[36] D. Elliott,et al. Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice. , 1998, Development.
[37] M. Frasch,et al. Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired. , 2000, Development.
[38] W. McGinnis,et al. Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation , 1999, The EMBO journal.
[39] R. Schulz,et al. Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis. , 2001, Developmental biology.
[40] H. Arnold,et al. Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeo☐ gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development , 1996, Mechanisms of Development.
[41] C. Abate-Shen,et al. A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[42] R A Schulz,et al. D‐mef2 is a target for Tinman activation during Drosophila heart development , 1997, The EMBO journal.
[43] M. Scott,et al. What determines the specificity of action of Drosophila homeodomain proteins? , 1990, Cell.
[44] A. Usheva,et al. Characterization of Homo- and Heterodimerization of Cardiac Csx/Nkx2.5 Homeoprotein* , 2001, The Journal of Biological Chemistry.
[45] Ryozo Nagai,et al. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation , 2001, Nature Genetics.
[46] R. Schulz,et al. The Homeodomain Transcription Factor NK-4 Acts as either a Transcriptional Activator or Repressor and Interacts with the p300 Coactivator and the Groucho Corepressor* , 1999, The Journal of Biological Chemistry.
[47] M. Frasch,et al. Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors. , 2001, Developmental biology.
[48] M. Nirenberg,et al. The three-dimensional solution structure of the NK-2 homeodomain from Drosophila. , 1995, Journal of molecular biology.
[49] Stephen S. Gisselbrecht,et al. Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors , 2000, Cell.
[50] L Hartley,et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. , 1995, Genes & Development.
[51] C. Schnabel,et al. Repression by HoxA7 is mediated by the homeodomain and the modulatory action of its N-terminal-arm residues , 1996, Molecular and cellular biology.
[52] J. Borlak,et al. Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations. , 2004, The American journal of pathology.
[53] Y. Jan,et al. Miranda Is Required for the Asymmetric Localization of Prospero during Mitosis in Drosophila , 1997, Cell.
[54] T. Lints,et al. XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. , 1994, Developmental biology.
[55] M. Fishman,et al. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. , 1996, Development.